Advantages, disadvantages and alternatives to using adult heart failure clinical trials to guide pediatric heart failure therapy

Heart failure in the adult population is a major public health issue with an estimated prevalence of 5.8 million affected adults in the USA and over 23 million worldwide [1]. The majority of adult heart failure in Western High Income locations is related to ischemia, hypertension and valvular heart disease [2]. Other comorbidities are common, including diabetes, renal insufficiency, arrhythmias and hypercholesterolemia. The diagnosis of heart failure in adult patients carries a significant risk of death.
Source: Progress in Pediatric Cardiology - Category: Cardiology Authors: Tags: Review Source Type: research