Markers as predictors of clinical worsening in pulmonary arterial hypertension

Various biomarkers have been demonstrated to represent prognostic markers in adult patients with pulmonary arterial hypertension (PAH), however few data are available on their value in pediatric population. We aimed to assess the role of serum and imaging markers, such as B-type natriuretic peptide (BNP) and echocardiography-derived parameters characterizing right ventricular function and hemodynamics, in predicting clinical worsening in pediatric PAH. In 28 pediatric patients with PAH (group 1 - patients clinically stable at 12months “no clinical worsening”, n=14, 50%; group 2 - patients with clinical worsening at 12months “clinical worsening”, n=14, 50%), BNP, echocardiographic parameters (at baseline, 6months and 12months), World Health Organization functional class (“WHO FC”), 6-minute walk test (6MWT) were correl ated with clinical status at 12months.

Source: Progress in Pediatric Cardiology - June 21, 2017 Category: Cardiology Authors: Suteu Carmen Corina, Blesneac Cristina, Muntean Iolanda, Benedek Imre, Benedek Theodora, Iarca Ionut, Melinte Mihaela, Tog ănel Rodica Source Type: research