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Mental Health 2017: Implementing the Five Year Forward View
At the Mental Health 2017: Implementing the Five Year Forward View conference held in September 2017 at the Royal Society of Medicine, delegates were informed on the current government plans to focus attention on perinatal and children's mental health, to bring mental health care from institutions into the community and integrate physical and mental health services. Felix David here reports on some of the conference highlights. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - November 27, 2017 Category: Neurology Authors: Felix David Tags: Conference Source Type: research

Association between antipsychotics and adverse outcomes in dementia
Prolonged use of antipsychotics continues to be a controversial subject area, especially in the older adult population due to age‐related changes in pharmacokinetic and pharmacodynamics parameters. Best practice guidelines recommends that they should be used at their lowest dosage for no longer than 6–12 weeks. Here, the authors discuss the prevalence of antipsychotic use to treat the behavioural and psychological symptoms of dementia in the older adult population and the dilemma it poses. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - November 27, 2017 Category: Neurology Authors: Ayesha Bangash, Rebecca Stubbs, Farooq Khan, Sheliza Samnani, Humaira Aziz, Madhumanti Mitra Tags: Original research Source Type: research

Recurrent transient global amnesia: is there a link to familial history?
Although most episodes of transient global amnesia (TGA) are single or unique, there is a low recurrence rate. The factors associated with recurrence are uncertain. In this article, Dr Larner describes a patient with recurrent TGA and a positive family history, which prompted consideration of the possible role of genetic factors in TGA recurrence. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - November 27, 2017 Category: Neurology Authors: Andrew J Larner Tags: Case notes Source Type: research

A case report of olanzapine and related cardiac conduction changes
The use of certain psychotropic medications can be associated with serious ventricular arrhythmia and sudden cardiac death. In this article, the authors use the QTc value in a patient treated with olanzapine for psychotic depression to highlight the challenges in balancing psychotropic medication against cardiac conduction changes. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - November 27, 2017 Category: Neurology Authors: Sheeba Ninan, David Hinchcliffe, Samuel Amo ‐Korankye Tags: Case notes Source Type: research

SSRI ‐induced severe adverse cutaneous reaction – a case report
As selective serotonin re‐uptake inhibitors (SSRIs) are commonly prescribed, less common side‐effects such as severe adverse cutaneous drug reactions (ACDRs) can be seen more frequently than with less frequently prescribed antidepressants. Sertraline is among the better tolerated SSRIs. Here, we describe a case of a sertraline‐induced severe ACDR in a patient with depressive symptoms and cognitive impairment. The selection of an appropriate antidepressant proved challenging. A review of recent literature on the clinical and temporal presentation of SSRI‐induced ACDRs is presented with management strategies. (Source...
Source: Progress in Neurology and Psychiatry - November 27, 2017 Category: Neurology Authors: Andrew Byrne, Sian Arkell, Priya Bandi Tags: Case notes Source Type: research

Daclizumab: another option for highly active relapsing ‐remitting MS
Daclizumab provides clinicians with a new treatment option for patients with relapsing‐remitting multiple sclerosis. Here the authors consider its benefits compared with other multiple sclerosis drugs and its likely place in therapy. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - October 1, 2017 Category: Neurology Authors: Tarek Gaber, Clare Shippen Tags: Comment Source Type: research

Delayed ‐onset post‐traumatic stress disorder symptoms in dementia
Post‐traumatic stress disorder (PTSD) is commonly associated with working‐age adults and remains largely unrecognised in the elderly. In this review, Clara Martinez‐Clavera et al consider three examples of delayed‐onset PTSD and its frequent association, or misdiagnosis, as one of the numerous manifestations of the behavioural and psychological symptoms of dementia (BPSD). Finally, recommendations for pharmacological and psychological interventions are suggested. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 31, 2017 Category: Neurology Authors: Clara Martinez-Clavera, Sarah James, Eva Bowditch, Tarun Kuruvilla Tags: Review Source Type: research

Improving the referral process from primary care to an AMHT
There is established evidence that discrepancy rates in referral thresholds from GPs to secondary care services as high as 10‐fold exist between individual GPs. Andrew Molodynski et al looked systematically at the amount and quality of referrals to the secondary care team in order to identify any issues and develop support for referrers to make the process as smooth as possible. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 31, 2017 Category: Neurology Authors: Aaron Dehghan, Maan Abu Nowar, Andrew Molodynski Tags: Original Research Source Type: research

Prescribing quality improvement: reducing high ‐dose antipsychotic use
Evidence of efficacy for high‐dose antipsychotic therapy (HDAT) and antipsychotic combinations (AC) is lacking, while evidence of harm is compelling. Significantly higher proportions of Norfolk and Suffolk NHS Foundation Trust (NSFT) patients were being prescribed HDAT and AC compared with the national averages. Here, the authors describe a quality improvement program to rationalise and reduce HDAT and AC prescribing in NSFT, to bring it in line with, or below, the national average. The initiative demonstrates that prescribing culture can be improved through a sustained multi‐professional team approach involving educat...
Source: Progress in Neurology and Psychiatry - August 31, 2017 Category: Neurology Authors: Asta R Prajapati, Esther Johnston, Uju Ugochukwu, Bohdan Solomka Tags: Original research Source Type: research

Two case studies of clozapine ‐induced myocarditis
There is currently limited knowledge about which side‐effects patients will experience from clozapine. In this article, the authors describe two cases of patients who developed myocarditis during the initiation period of clozapine. The cases also illustrate the difficulty in diagnosing clozapine‐induced myocarditis due to the non‐specific nature of the symptoms. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 31, 2017 Category: Neurology Authors: Nargiza Saidova, Sian Llewellyn ‐Jones Tags: Case notes Source Type: research

NMDAR antibody encephalitis and fluctuating catatonia
N‐Methyl D‐aspartate receptor (NMDAR) antibody encephalitis has varied presentations and may often be seen in psychiatry because of a range of associated psychiatric manifestations. Here, the authors present a case of prolonged catatonia that occurred in episodes and continued for months before being successfully diagnosed as a cause of NMDAR antibody encephalitis. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 31, 2017 Category: Neurology Authors: Nilamadhab Kar, Manoj T Kumar, Socorro Barreto Tags: Case notes Source Type: research

When mania is not mania: a case of frontotemporal dementia
Imaging is a vital diagnostic tool to help distinguish frontotemporal dementia (FTD) from other neurodegenerative conditions. Here, the authors present the case of a 76‐year‐old man, without a history of mental disorders, suffering acute FTD that was clinically similar to a manic episode. The finding from neuroimaging is described along with the successful pharmacological management of the patient. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 31, 2017 Category: Neurology Authors: Panagiotis ‐Georgios Prevezanos, Raja Badrakalimuthu, Tracey Eddy Tags: Case Notes Source Type: research

Low ‐dose baclofen for treatment of alcohol dependence
This report highlights the case of a patient on low‐dose baclofen and the sustained improvement he achieved with the treatment. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 31, 2017 Category: Neurology Authors: Mohamed Al ‐Garhy, Sona Varghese Tags: Case notes Source Type: research

Mobile app: living and dying well with dementia
Digital technology is gaining wider use in healthcare. Here the authors consider whether a mobile application (app) they have developed could help promote understanding of dementia, its impact on those affected and to focus formal and family carers on key issues in end of life care. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - July 1, 2017 Category: Neurology Authors: Sarmishtha Bhattacharyya, Susan Mary Benbow, Eve Collins, Tags: Comment Source Type: research

Surgical procedures and postoperative cognitive dysfunction
Postoperative cognitive dysfunction is a serious side effect of surgery with the potential to affect the long‐term wellbeing of patients. Here the authors discuss the risk factors and possible aetiology of the disorder. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - May 31, 2017 Category: Neurology Authors: Anand Beri Tags: Comment Source Type: research