Progress in Neurology and Psychiatry 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Early intervention in psychosis: another triumph of hope over experience?
Evidence that longer duration of untreated psychosis (DUP) was associated with poor premorbid functioning in the year before onset, insidious onset and more negative symptoms at onset, led to the assumption that reducing DUP could improve long‐term outcome – hence the development of early intervention in psychosis (EIP) services. The authors investigate the evidence for and against EIP services and discuss how societal/family issues can also strongly influence mental health. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - June 9, 2015 Category: Neurology Authors: Ann Mortimer, Timothy Brown Tags: Review Source Type: research
Haemochromatosis and dementia: cause or contributor?
Haematological conditions, including haemochromatosis, have been reported as predictors of cognitive decline in their own right. Here, the authors describe a case of
accelerated cognitive decline in a patient newly diagnosed with Alzheimer's dementia and the possible effect of haemochromatosis on the patient's dementia progression. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - June 9, 2015 Category: Neurology Authors: Bheemraya Hanmanthraya, Andrew Byrne Tags: Case notes Source Type: research
Epigenetics – a cause for optimism?
(Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - May 1, 2015 Category: Neurology Authors: Mark Hanson Tags: Comment Source Type: research
Digest
£30 million invested in dementia research
The charity Alzheimer's Research UK (www.alzheimersresearchuk.org) has invested §30 million over the next five years with the aim of attracting world‐leading dementia researchers to the UK.
The funding will support research programmes in a Drug Discovery Alliance, comprising dedicated centres at the universities of Cambridge, Oxford and University College, London. In a model borrowed from successful initiatives by cancer charities, they will pool expertise and work collaboratively to identify and develop candidate molecules, and it is hoped that other centres will join the alli...
Source: Progress in Neurology and Psychiatry - April 9, 2015 Category: Neurology Tags: Digest Source Type: research
Management of depression in children and adolescents
As part of our series on managing neurological and psychiatric conditions in children and adolescents, Dr Julia Gledhill and Dr Matthew Hodes discuss depression. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - April 9, 2015 Category: Neurology Authors: Julia Gledhill, Matthew Hodes Tags: Review Source Type: research
An audit of younger patient referrals to a memory clinic
With memory services generally set up to cope with the demands of an older age group, meeting the needs of younger patients with dementia has its difficulties and there is a possibility of service saturation. Dr Richards and colleagues describe their audit of a memory assessment service in Cornwall, which highlights the urgent need for more thorough screening assessment in primary care of younger patients before they reach the memory clinic. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - April 9, 2015 Category: Neurology Authors: Allison O'Kelly, Giles Richards, Manuel Figueroa Gorospe Tags: Original research Source Type: research
Beware of a diagnosis of TIA in a young patient
Cavernomas are abnormal vascular lesions consisting of many small lobules, like a bunch of small berries. They may be asymptomatic or they may present with seizures, in around 60% of cases, or symptoms similar to a transient ischaemic attack (TIA) or stroke. Here, the authors describe a case of a 30‐year‐old woman who presented with TIA‐like symptoms for which treatment was started. Imaging revealed a spinal cord cavernoma, after which the course of management was changed and the patient referred to the neurosurgeons. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - April 9, 2015 Category: Neurology Authors: Sarim Kamal Omar, Mazen Rizeq Tags: Case notes Source Type: research
Delusional infestation: first case in the intellectually disabled population
Delusional infestation is a rare primary delusional disorder. Here, Drs Sharaf and Thevathasan describe a case of delusional infestation in an intellectually disabled patient, along with the patient's marked response to aripiprazole. Also apparent are the patient's presentation differences from the classically reported primary disorder. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - April 9, 2015 Category: Neurology Authors: Adnan Sharaf, Pravin Thevathasan Tags: Case notes Source Type: research
Was dementia with Lewy bodies described by Sir William Gowers (1845–1915) in the nineteenth century?
(Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - April 9, 2015 Category: Neurology Authors: Andrew J. Larner Tags: Letter Source Type: research
The complex enigma of autism
Autism isolates individuals in society, denying them access to the complex world of social interaction. Mark Greener reviews some of the recent research into the genetic, molecular and neuroanatomical basis of ASD's diverse clinical presentation. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - April 9, 2015 Category: Neurology Authors: Mark Greener Tags: News review Source Type: research
Review of under 65 years referrals to a memory clinic
O'Kelly et al. (see p21) highlight some significant issues resulting from the increased emphasis on the importance of recognising dementia in people under 65 years of age and the impact this is having on memory assessment services that are run by old age mental health services who usually cater for people over the age of 65 years. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - March 1, 2015 Category: Neurology Authors: Jill Rasmussen Tags: Comment Source Type: research
Digest
Isotretinoin safety reminder
The Medicines and Healthcare Products regulatory Agency (MHRA) has reminded prescribers to monitor patients treated with the retinoid isotretinoin for depression and to warn patients and their families to be alert for symptoms and suicidal thoughts (Drug Safety Update 2914;8(5):A2). The MHRA warns that stopping isotretinoin may not be enough to relieve symptoms and further psychiatric or psychological evaluation may be needed.
Isotretinoin, available as the brands Roaccutane and Rizuderm, is licensed for the treatment of severe acne resistant to systemic antibacterials and topical therapy. (Sou...
Source: Progress in Neurology and Psychiatry - February 5, 2015 Category: Neurology Tags: Digest Source Type: research
Functional neuroimaging for dementia: commissioning and evaluating a service
This article describes how the authors developed a business case leading to a one‐year pilot and eventually recurrent funding for 40 FDG‐PET/CT and five DaTscans per year. It presents the evaluation of the first two years of operation. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - February 5, 2015 Category: Neurology Authors: Tarun Kuruvilla, Emma Phillips, Binuja Justin, Philippa Rose, Iain Lyburn Tags: Original research Source Type: research
Speed versus accuracy in cognitive assessment when using CSIs
When using cognitive screening instruments (CSIs) there is always a balance to be struck between test sensitivity and specificity, with the chosen test cut‐off being determined by the needs of the particular clinical situation. Dr Larner investigates whether there is a trade‐off between CSI diagnostic accuracy and administration time, or, in other words, whether shorter CSIs are less accurate than longer ones which may sample more cognitive domains and/or in greater depth. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - February 5, 2015 Category: Neurology Authors: Andrew J Larner Tags: Original research Source Type: research
Are psychological therapies effective in treating schizophrenia and psychosis?
(Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - February 5, 2015 Category: Neurology Authors: Peter Kinderman, Peter McKenna, Keith R Laws Tags: Debate Source Type: research
