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Leadership: stress and hubris
Why do some leaders, from all walks of life, succumb to hubris – arrogance, overweening pride and contempt for others? These questions were the focus of ‘Leadership: stress and hubris’, a conference organised by the Daedalus Trust in conjunction with the British Psychological Society at the Royal Society of Medicine in London in November 2014. Delegates heard about the psychological and biological effects of stress in triggering hubristic behaviour in leaders and possible ways to check its malign effects. Joy Ogden reports. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - February 5, 2015 Category: Neurology Authors: Joy Ogden Tags: Conference Source Type: research

A persisting perception disorder after cannabis use
Hallucinogen persisting perception disorder is a disorder of uncertain aetiology occurring mainly after ‘classical’ hallucinogen use (ie mescaline, psilocybin, dimethyltryptamine and LSD) use. Here, the authors describe the case of a boy with similar symptoms developing after he reported using cannabis seven times. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - February 5, 2015 Category: Neurology Authors: Zoë Ellison‐Wright, Ben Sessa Tags: Case notes Source Type: research

Don't underestimate glial cells
For decades, glial cells languished in relative obscurity. Neurones attracted the interest, kudos and research funding. Here, Mark Greener reports on recent developments in our understanding of the significant role played by glial cells in health and disease. Insights into glial cells' pathological importance and the growing appreciation of their role in normal brain function could offer the prospect of new treatments for multiple sclerosis, Parkinson's and Alzheimer's disease, and many other conditions. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - February 5, 2015 Category: Neurology Authors: Mark Greener Tags: News review Source Type: research

Improving diagnosis of dementia in primary care
Our commentaries from the Primary Care Neurology Society (P‐CNS) provide a primary care perspective on neurology articles featured in Progress. Here, Drs Susan Mary Benbow, David Jolley and Ian Greaves consider ‘Speed versus accuracy in cognitive assessment’ (see page 21). (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - January 1, 2015 Category: Neurology Authors: Susan Mary Benbow, David Jolley, Ian Charles Greaves Tags: Comment Source Type: research

Digest
Diabetes drugs for Alzheimer's disease? Lixisenatide and liraglutide, GLP‐1 agonists licensed for the treatment of type 2 diabetes, have been shown to reverse brain changes in a murine model of Alzheimer's disease (Neuropharmacol 2014;86:241–58). Researchers from the University of Lancaster showed that after 10 weeks' administration to mice in which amyloid plaques had formed, cognitive function was improved and plaque load and microglial activation were reduced. Through the Alzheimer's and Parkinson's Trust North West (www.apt‐northwest.org), they are now seeking additional funding to enable current trials to be com...
Source: Progress in Neurology and Psychiatry - December 3, 2014 Category: Neurology Tags: Digest Source Type: research

Neuroscience 2014
Last month, 30 000 of the world's neuroscientists gathered to discuss research and share their latest findings in Washington, DC. Rob Munro reports on some key presentations. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - December 3, 2014 Category: Neurology Authors: Rob Munro Tags: Conference Source Type: research

Role of metformin in the management of antipsychotic‐induced weight gain
Overweight and obesity are a threat to health, longevity and quality of life. With the growing trend of using atypical antipsychotics for various psychiatric disorders, concern regarding adverse effects has shifted from extrapyramidal side effects to weight gain and metabolic abnormalities. In this review, the author analyses the extent of the problem, the evidence base for using metformin to counteract the weight gain, and prescribing advice for using metformin effectively. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - December 3, 2014 Category: Neurology Authors: Asta R Prajapati Tags: Review Source Type: research

The pharmacological management of anxiety disorders
Progress in Neurology and Psychiatry is running a series of updated articles on the major psychiatric drug groups, produced in association with the College of Mental Health Pharmacy (www.cmhp.org.uk). In this article, Stephen Bleakley and Simon Davies provide an overview of the main types of anxiety disorders, obsessive compulsive disorder and post‐traumatic stress disorder. The article focuses on the drug treatment options and supporting evidence base. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - December 3, 2014 Category: Neurology Authors: Stephen Bleakley, Simon JC Davies Tags: Review Source Type: research

Advantages of pre‐clinic brain imaging prior to attending memory clinics
The demand for memory assessment is increasing due to the dementia CQUIN and increased public awareness of dementia. Drs Huwez, Perera and Ewins describe an innovative approach of pre‐clinic imaging and investigation which removed the need for a follow‐up appointment, and also resulted in increased availability of clinic slots. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - December 3, 2014 Category: Neurology Authors: Farhad Huwez, Saman Perera, Katie Ewins Tags: Original research Source Type: research

Third ventricular colloid cyst and organic hypomania
A colloid cyst is a cyst containing gelatinous material in the brain. Some colloid cysts result in acute onset of hydrocephalus and may lead to sudden death, and colloid cysts of the third ventricle frequently cause psychiatric disturbances leading to erroneous diagnosis of schizophrenia and neurosis. Here, Drs Javed and Dutta describe a case of third ventricle colloid cyst presenting with a seemingly functional psychiatric illness, which was treated neurosurgically and showed complete resolution of symptoms. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - December 3, 2014 Category: Neurology Authors: Qaiser Javed, Arpan Dutta Tags: Case notes Source Type: research

Cerebral calcification from Fahr's disease with co‐existing haemochromatosis
An elderly man with a history of hereditary haemochromatosis, Parkinsonism and a pituitary macroadenoma presented with limb weakness and slurred speech. He underwent computer tomography of his head, which showed extensive basal ganglia, and periventricular and cerebellar calcification consistent with Fahr's syndrome. The degree of the calcification and lack of precipitating factors led to a likely diagnosis of Fahr's disease. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - December 3, 2014 Category: Neurology Authors: Tim Scale, Chris Lewis, Ahmad Bilal Hedayat, Mushtaq Wani Tags: Case notes Source Type: research

The link between laughing death and Alzheimer's disease
Research that began by investigating Kuru (the laughing death) is now helping us understand several neurodegenerative diseases, including Alzheimer's disease. Mark Greener reports on recent developments. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - December 3, 2014 Category: Neurology Authors: Mark Greener Tags: News review Source Type: research

Antidepressants and psychological therapies are effective for IBS
(Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - December 3, 2014 Category: Neurology Tags: Poem Source Type: research

Primary care management of anxiety throughout the patient journey
Our series of commentaries from the Primary Care Neurology Society (P‐CNS) provide a primary care perspective on neurology articles featured in Progress in Neurology and Psychiatry. Here, Dr Jane Stephens discusses ‘The pharmacological management of anxiety disorders’ (see page 27) (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - November 1, 2014 Category: Neurology Authors: Jane Stephens Tags: Comment Source Type: research

Digest
US new drug approvals The US Food and Drug Administration has granted marketing approval to several compounds ahead of their European regulatory counterpart. Lacosamide (Vimpat) is now approved as monotherapy for partial onset seizures in patients aged over 17. In Europe it is currently limited to adjunctive therapy, though a monotherapy indication will be pursued pending the outcome of a comparative trial against carbamazepine. Peginterferon beta‐1a (Plegridy), administered as a fortnightly subcutaneous injection, has been approved for relapsing forms of multiple sclerosis. Eliglustat (Cerdelga) has been approved for th...
Source: Progress in Neurology and Psychiatry - October 9, 2014 Category: Neurology Tags: Digest Source Type: research