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Digest
Abstract
Prescribing prospects promising
US pharmaceutical companies have no fewer than 119 new drugs in development for the treatment of mental health disorders and addiction, according to a report from the Pharmaceutical Research and Manufacturers of America (www.phrma.org).
There are 36 pipeline products for schizophrenia, including selective phosphodiesterase inhibitors, which may be effective against negative symptoms and do not cause cognitive impairment. The 44 new drugs for depression or anxiety disorders include a combined opioid modulator/agonist and a new class of pherines for social anxiety disorder. A triple n...
Source: Progress in Neurology and Psychiatry - June 5, 2014 Category: Neurology Tags: Digest Source Type: research
Mood stabilisers in the management of bipolar affective disorder
Abstract
As part of our series on the major psychiatric medication groups, produced in association with the College of Mental Health Pharmacy (CMHP; www.cmhp.org.uk), Michele Sie discusses the choice and use of medicines in the management of bipolar affective disorder. Pharmacology, interactions and side‐effects, as well as information to give to patients, are described. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - June 5, 2014 Category: Neurology Authors: Michele Sie Tags: Review Source Type: research
Efficacy of clozapine in early intervention
(Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - June 5, 2014 Category: Neurology Authors: Dilhan Ekanayake, Catherine Dumughn, Harpal Nandhra Tags: Letter Source Type: research
Transient psychotic episodes following recreational use of NRG‐3
Abstract
The increased availability of novel psychoactive substances or ‘legal highs’ over the internet has made screening for recreational drug use much more difficult for doctors in recent years. Here, Drs Kihara and Day describe the case of a young male patient repeatedly presenting with transient psychotic episodes who eventually revealed that each episode had followed the use of NRG‐3 obtained from the internet. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - June 5, 2014 Category: Neurology Authors: Rhiannon Kihara, Edward Day Tags: Case notes Source Type: research
Differential response to antipsychotics in a patient with Alzheimer's disease
Abstract
Risperidone is the only antipsychotic currently licensed for the behavioural and psychological symptoms of dementia. Drs Rachis and Shankar describe the case of an elderly man with Alzheimer's disease who developed behavioural symptoms and delusions, who responded well to aripiprazole after treatment with risperidone failed. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - June 5, 2014 Category: Neurology Authors: Dina Rachis, Kuttalingam Shankar Tags: Case notes Source Type: research
Food for thought: the ketogenic diet for epilepsy
Abstract
It has been known since the 1920s that the ketogenic diet is effective for the control of seizures in people of all ages with epilepsy, yet it remains underused today. Mark Greener discusses the possible mechanisms of action, tolerability issues and how the diet could be modified to increase uptake. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - June 5, 2014 Category: Neurology Authors: Mark Greener Tags: Research Source Type: research
The ketogenic diet: a work in progress
Abstract
Our Commentaries from the Primary Care Neurology Society (P‐CNS) provide a primary care perspective on the neurology articles in Progress. Here, Dr Karen Lanyon considers ‘Food for thought ‐ the ketogenic diet for epilepsy’ (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - May 1, 2014 Category: Neurology Authors: Karen Lanyon Tags: Comment Source Type: research
Digest
Abstract
Latest Advances in Psychiatry
The 13th Latest Advances in Psychiatry Symposium, organised by Progress in Neurology and Psychiatry in association with the International Society for Affective Disorders (ISAD) was held at the Royal College of Physicians in London on 12th March. The theme of the meeting was ‘Biopsychosocial Approaches to Psychiatry’ and around 120 psychiatrists attended. Professor Sir Simon Wessely provided a very thought‐provoking Keynote Lecture, entitled ‘Psychiatry Under Fire’. Other speakers included Professor Guy Goodwin, Dr Paul Ramchandani and Professor Ian Jones; and Professor Allan...
Source: Progress in Neurology and Psychiatry - April 8, 2014 Category: Neurology Tags: Digest Source Type: research
Post‐ictal psychosis in a patient with a history of nocturnal epilepsy
Abstract
Psychiatric symptoms can occur following a seizure (post‐ictal) in patients with epilepsy. Here, Drs Datta and Oladinni describe the case of a man with a history of nocturnal epilepsy, who developed psychotic symptoms following two successive seizures. Copyright © 2014 John Wiley & Sons (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - April 8, 2014 Category: Neurology Authors: Aarti Datta, Olakunle Oladinni Tags: Case notes Source Type: research
Effects of introducing MEWS on nursing staff in mental health inpatient settings
Abstract
The Modified Early Warning Score (MEWS) is now commonly used in the assessment of physically unwell patients in non‐acute hospital wards. The effect of the introduction of MEWS on the confidence of inpatient psychiatric nurses in identifying the severity of a physically deteriorating patient, and taking appropriate clinical action, has not been reported previously. The authors undertook a cross sectional survey looking at the level of confidence of qualified mental health nurses, and their ability to make correct clinical decisions, before and after introduction of the MEWS tool. Copyright © 2014 John Wiley &am...
Source: Progress in Neurology and Psychiatry - April 8, 2014 Category: Neurology Authors: Farshad Shaddel, Vivek Khosla, Subimal Banerjee Tags: Original research Source Type: research
Management of neuropsychiatric symptoms in multiple sclerosis
Abstract
Multiple sclerosis is associated with a high prevalence of psychiatric comorbidity, including affective, psychotic and cognitive disorders. In this review, Dr Sommerlad and colleagues discuss the epidemiology, aetiology and management of neuropsychiatric symptoms in multiple sclerosis, using case vignettes to demonstrate the wide range of clinical presentations. Copyright © 2014 John Wiley & Sons (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - April 8, 2014 Category: Neurology Authors: Andrew Sommerlad, Gary Price, Anand Trip Tags: Review Source Type: research
Delirium associated with therapeutic levels of lithium in bipolar disorder
Abstract
Lithium has been associated with neurotoxicity even at ‘therapeutic’ levels. This case report describes a patient with bipolar disorder who developed signs of delirium following an increase in her dose of lithium, even though her serum levels remained in the therapeutic range. Copyright © 2014 John Wiley & Sons (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - April 8, 2014 Category: Neurology Authors: Zoe Clough, Rebecca Henry, Anders Ekelund Tags: Case notes Source Type: research
Charles Bonnet syndrome: an enigmatic neurological condition
Abstract
Charles Bonnet syndrome is a neurological disease characterised by clear, recurrent visual hallucinations usually following visual loss. It is often misdiagnosed as psychosis, delirium or early dementia, but patients generally retain insight. Mark Greener discusses what we currently know about this fascinating condition and what remains a mystery. Copyright © 2014 John Wiley & Sons (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - April 8, 2014 Category: Neurology Authors: Mark Greener Tags: News review Source Type: research
Improving care of patients with MS and psychiatric disorders in general practice
Abstract
Our series of Commentaries from the Primary Care Neurology Society (P‐CNS) provide a primary care perspective on the neurology articles featured in Progress in Neurology and Psychiatry. Here, Dr Nassif Mansour considers ‘Management of neuropsychiatric symptoms in multiple sclerosis’ (see page 14). Copyright © 2014 John Wiley & Sons (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - March 1, 2014 Category: Neurology Authors: Nassif S Mansour Tags: Comment Source Type: research
Digest
Abstract
Major international initiative tackles dementia
The G8 countries have agreed measures that will increase funding for research into treatments for dementia with the goal of identifying a cure or disease‐modifying therapy by 2025. At a meeting in London hosted by the UK Government, Canada, France, Germany, Italy, Japan, Russia, the UK and the USA pledged to appoint a ‘global dementia innovation envoy’ who can utilise ‘international expertise to stimulate innovation and co‐ordinate international efforts to attract new sources of finance’. Copyright © 2014 John Wiley & Sons (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - February 11, 2014 Category: Neurology Tags: Digest Source Type: research