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New biomarker-based strategies for a preventive and personalized diagnosis of acute kidney injury
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Francisco J. López-Hernández Acute kidney injury (AKI) is a very relevant and increasing health and socioeconomic problem worldwide. In critically ill patients, mortality to AKI may reach up to 50-80% of the cases. Even mild, spontaneously reversible episodes of AKI have a significant impact on medium and long term morbidity and mortality. Drug nephrotoxicity is among the most important causes of AKI, with 25% of the 100 most used drugs in intensive care units being nephrotoxic. AKI has been traditionally diagn...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Advanced light microscopy: More than accessory technologies for pathophysiological research
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Josef Gotzmann Light Microscopy is one of the most valuable and versatile tools in biomedical research. Imaging “infiltrated” all kinds of natural science categories, serving cell and developmental biologists, pathobiologists, physicists, material scientists, chemicals, pharmaceutical specialists and clinicians, thereby acting as THE “translational” method. In recent years we observed fast and revolutionary development of new biooptical technologies, as well as a boom in fluorophore engineering towards ad...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Translational imaging - What, why and how?
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Luc Bidaut Through its varied instances, technologies and applications, biomedical imaging readily lends itself to translational approaches from in-vitro all the way to clinical. Whereas the disciplines, technologies, scales and scopes vary throughout the translational pipeline, they tend to coalesce when reaching the in-vivo context (e.g., through animal models), which ideally then leads to direct evaluation, validation and application in the human. This presentation will focus on demonstrating such a potential ...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Translational research at NASA: From earth to space and back again
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Thomas J. Goodwin The Space Environment provides many challenges to the human physiology and therefore to extended habitation and exploration. Translational research and medical strategies are meeting these challenges by combining Earth based medical solutions with innovative and developmental engineering approaches. Translational methodologies are currently applied to spaceflight related dysregulations in the areas of: (1) cardiovascular fluid shifts, intracranial hypertension and neuro-ocular impairment 2) immu...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Accredited translational medicine centre Human renal fibrotic disease: Translational research at the Center for Cell Biology and Cancer Research (CCBCR), Albany Medical College, Albany, NY
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Paul J. Higgins , Aamir Shahzad , Jeffrey Kennedy Translational studies conducted in the Center for Cell Biology & Cancer Research at the Albany Medical College integrate the discovery of basic mechanisms underlying the development of human fibrotic disease with in vivo interventional strategies and tissue repair outcomes in animal models. This structured research program is expected to lead to the clinical adaptation of novel therapies specifically directed to the control of pathologically-relevant pro...
Source: New Horizons in Translational Medicine - January 21, 2015 Category: Research Source Type: research

Methodologies and limitations in the analysis of potential neuroprotective compounds derived from natural products
Publication date: Available online 16 January 2015 Source:New Horizons in Translational Medicine Author(s): John T. Weber Plant-derived polyphenols have attracted the attention of scientists, the public, and the media due to their potential use as nutraceutical products. The high quantities of polyphenols found in some berry species, e.g. Vaccinium species such as blueberries and lingonberries, and their reported antioxidant and anti-inflammatory properties, could be beneficial for brain aging and neurodegenerative disorders. The neuroprotective potential of various polyphenolic compounds have been validated using a v...
Source: New Horizons in Translational Medicine - January 18, 2015 Category: Research Source Type: research

Translational medicine definition by the European society for Translational medicine
Publication date: Available online 11 December 2014 Source:New Horizons in Translational Medicine Author(s): Randall J. Cohrs , Tyler Martin , Parviz Ghahramani , Luc Bidaut , Paul J. Higgins , Aamir Shahzad Progress in the field of translational medicine (TM) within the last decade attests to the importance of the TM initiative in the context of more traditional academic health science centers. In many instances, these advancements have taken place without a clear definition of TM, which signifies the urgent need for a clear, consensus definition that would serve as an integrative blueprint for the various “ve...
Source: New Horizons in Translational Medicine - December 11, 2014 Category: Research Source Type: research

Human renal fibrotic disease: Translational research at the center for cell biology and Cancer research (CCBCR), Albany medical college, Albany, NY
Publication date: Available online 8 December 2014 Source:New Horizons in Translational Medicine Author(s): Paul J. Higgins , Aamir Shahzad , Jeffrey Kennedy (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - December 9, 2014 Category: Research Source Type: research

The role of chemical elements in melanoma
Publication date: Available online 27 November 2014 Source:New Horizons in Translational Medicine Author(s): Angelo M. Facchiano , Francesco Facchiano , Antonio Facchiano Publication of several studies attest the growing interest to investigate the real impact chemical elements and industrial pollution may play have on the human health. In the current study we present novel data referring to the occurrence of the name of all chemical elements taken from the Mendeleev table, in the title of PubMed indexed melanoma articles. Nine hundred fifty four manuscripts were found to have in the title field the “melanoma” w...
Source: New Horizons in Translational Medicine - November 28, 2014 Category: Research Source Type: research

Revolutionary Impact of Nanovaccines on Immunotherapy
Publication date: Available online 18 November 2014 Source:New Horizons in Translational Medicine Author(s): Mohammad-Ali Shahbazi , Hélder A. Santos Over the past few decades, public health has been immensely improved by preventing various types of diseases using vaccination, a method implying attenuated, killed or part of a microorganism to activate the immune system against it. Recently, nanovaccines have attracted a lot of attention as a new approach for enhancing the immune responses against immunogenic molecules. A wide variety of nanomaterials are reported as proper candidates for nano-vaccination. Currently,...
Source: New Horizons in Translational Medicine - November 18, 2014 Category: Research Source Type: research

Emerging Pathways in Treating Human epidermal growth factor receptor-2-negative breast Cancer
Publication date: Available online 15 November 2014 Source:New Horizons in Translational Medicine Author(s): Sotirios Stergiopoulos Breast cancer remains the leading cause of new cancer cases in women and is responsible for the most cancer-related deaths in women worldwide. The goals of breast cancer treatment are to maintain or improve quality of life, prolong survival, and increase disease-free progression. The majority of breast cancer cases are estrogen receptor (ER)-positive and human epidermal growth factor receptor-2 (HER-2)-negative, and current treatment guidelines recommend multiple lines of endocrine therap...
Source: New Horizons in Translational Medicine - November 15, 2014 Category: Research Source Type: research

Translational research in hepatic encephalopathy: new diagnostic possibilities and new therapeutic approaches
Publication date: Available online 15 November 2014 Source:New Horizons in Translational Medicine Author(s): Marta Llansola , Carmina Montoliu , Ana Agusti , Vicente Hernandez-Rabaza , Andrea Cabrera-Pastor , Michele Malaguarnera , Belen Gomez-Gimenez , Alma Orts , Raquel Garcia-Garcia , Tiziano Balzano , Lucas Taoro , Vicente Felipo Chronic liver disease (e.g. cirrhosis) affects brain function. There is a high incidence of mild cognitive impairment and psychomotor slowing in patients with cirrhosis. This condition, known as minimal hepatic encephalopathy (MHE) affects more than 2 million people in the Euro...
Source: New Horizons in Translational Medicine - November 15, 2014 Category: Research Source Type: research

Curcumin: Towards molecularly targeted chemoprevention of cancer
Publication date: September 2014 Source:New Horizons in Translational Medicine, Volume 2, Issue 1 Author(s): Ulrich Pfeffer , Adriana Amaro , Beatrice Bachmeier , Giovanna Angelini Everybody is at risk for cancer yet environmental factors, life style and diet as well as genetic factors influence the individual cancer risk. Targeted or personalized cancer prevention is based on the knowledge of the molecular characteristics of the tumor to be prevented, the molecular mechanisms of action of the compounds to be used and the genetic make-up of the person who opts for prevention medicine. Genetic factors are to a certa...
Source: New Horizons in Translational Medicine - November 4, 2014 Category: Research Source Type: research

Small molecule PAI-1 functional inhibitor attenuates vascular smooth muscle cell migration and survival: Implications for the therapy of vascular disease
Publication date: September 2014 Source:New Horizons in Translational Medicine, Volume 2, Issue 1 Author(s): Tessa M. Simone , Paul J. Higgins Focal points • Bedside Targeted pharmacologic disruption of PAI-1 function with small molecule inhibitors may have general applicability for the treatment of fibroproliferative disorders, in general, and vascular disease, in particular. The development orally compatible drugs would likely simplify delivery and patient compliance. • Benchside It is apparent that PAI-1 is a multi-functional SERPIN, affecting such diverse physiological and pathophysiological processes as...
Source: New Horizons in Translational Medicine - November 4, 2014 Category: Research Source Type: research

Protein aggregation and Arfaptin2: A novel therapeutic target against neurodegenerative diseases
Publication date: September 2014 Source:New Horizons in Translational Medicine, Volume 2, Issue 1 Author(s): Aida M. Mohammedeid , Vera Lukashchuk , Ke Ning Therapeutic targets for neurodegenerative conditions are constantly emerging. Diseases such as amyotrophic lateral sclerosis and Huntington׳s disease are multifactorial and involve dysfunction of various cellular pathways. Protein aggregate formation is one of the crucial pathological signs of cellular dysfunction, and is characteristic of many neurodegenerative conditions. Proteins recruited to these aggregates are thought to play a role in formation of the pa...
Source: New Horizons in Translational Medicine - November 4, 2014 Category: Research Source Type: research