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Simian varicella virus is present in skin tissue of rhesus macaques after experimental reactivation
Publication date: May–July 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 4–5 Author(s): A Miller, V Traina-Dorge, A Blackmon, M Wellish, E Deharo, D Gilden, R Mahalingam Varicella zoster virus (VZV) causes varicella (chickenpox), establishes latency in ganglia and reactivates decades later to produce zoster in the elderly. Clinical, pathological, immunological and virological features of simian varicella virus (SVV) infection of primates parallel human VZV infection. Primary SVV infection of primates, cause varicella, after which virus becomes latent in ganglionic neurons and re...
Source: New Horizons in Translational Medicine - September 13, 2015 Category: Research Source Type: research

The 14th annual meeting of the rocky mountain virology association: Current Advances in virology and prion biology in the rocky mountain region
Publication date: May–July 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 4–5 (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - September 13, 2015 Category: Research Source Type: research

Accredited translational medicine centre
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Paul J. Higgins, Aamir Shahzad, Jeffrey Kennedy Translational studies conducted in the Center for Cell Biology & Cancer Research at the Albany Medical College integrate the discovery of basic mechanisms underlying the development of human fibrotic disease with in vivo interventional strategies and tissue repair outcomes in animal models. This structured research program is expected to lead to the clinical adaptation of novel therapies specifically directed to the control of pathologically-relevant pr...
Source: New Horizons in Translational Medicine - July 16, 2015 Category: Research Source Type: research

Bardet–Biedl syndrome: A model for translational research in rare diseases
Publication date: May–July 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 4–5 Author(s): Robert M. Haws , Anthony D. Krentz , Rachel V. Stankowski , Robert D. Steiner Bardet–Biedl syndrome (BBS) is a rare, multisystemic, genetic disease and member of a group of disorders called ciliopathies. This syndrome provides a mechanistic model for ciliopathies that may also extend to common disorders with complex inheritance patterns, including diabetes mellitus and obesity. Dysregulation of signaling pathways altering the cellular response to the extracellular environment is primary to the ciliop...
Source: New Horizons in Translational Medicine - July 2, 2015 Category: Research Source Type: research

Acute tubular necrosis: An old term in search for a new meaning within the evolving concept of acute kidney injury
Publication date: Available online 14 June 2015 Source:New Horizons in Translational Medicine Author(s): Sandra M. Sancho-Martínez , Laura Prieto , Víctor Blanco-Gozalo , Miguel Fontecha-Barriuso , Laura Vicente-Vicente , Alfredo G. Casanova , Marta Prieto , Moisés Pescador , Ana I. Morales , José M. López-Novoa , Carlos Martínez-Salgado , Francisco J. López-Hernández By the mid 2000s, the old term acute renal failure (ARF) was widened and superseded by the more inclusive concept of acute kidney injury (AKI). Whereas ARF referred to patients acutely needing dialysis to preserve life, AKI comprised a...
Source: New Horizons in Translational Medicine - June 14, 2015 Category: Research Source Type: research

Bardet-Biedl Syndrome: A Model for Translational Research in Rare Diseases
Publication date: Available online 14 June 2015 Source:New Horizons in Translational Medicine Author(s): Robert M. Haws , Anthony D. Krentz , Rachel V. Stankowski , Robert D. Steiner Bardet-Biedl syndrome (BBS) is a rare, multisystemic, genetic disease and member of a group of disorders called ciliopathies. This syndrome provides a mechanistic model for ciliopathies that may also extend to common disorders with complex inheritance patterns, including diabetes mellitus and obesity. Dysregulation of signaling pathways altering the cellular response to the extracellular environment is primary to the ciliopathies and c...
Source: New Horizons in Translational Medicine - June 14, 2015 Category: Research Source Type: research

Development of A decision-making biomarker for CRTH2 antagonism in clinical studies
Publication date: Available online 12 June 2015 Source:New Horizons in Translational Medicine Author(s): Daniel S. Strasser , Hervé Farine , Martin Holdener , Jochen Zisowsky , René Roscher , Julie Hoerner , Martine Gehin , Patricia N. Sidharta , Jasper Dingemanse , Peter M.A. Groenen Biomarkers have shown to improve success rates in the development of novel drugs, providing essential information in the early phases of clinical development for decision- making. Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is pursued as a drug target for a number of inflammatory diseases. CRTH2...
Source: New Horizons in Translational Medicine - June 12, 2015 Category: Research Source Type: research

Signal regulatory protein alpha (SIRPA) and kinase domain receptor (KDR) are key expression Markers in cardiac specific precursor selection from hADSCs
Conclusions Thus, SIRPA and KDR together provide cues in the enhancement and up-scaling of cardiomyocyte production in the cell replacement therapy. (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - April 7, 2015 Category: Research Source Type: research

Translational medicine and varicella zoster virus: Need for disease modeling
Publication date: Available online 30 March 2015 Source:New Horizons in Translational Medicine Author(s): Aamir Shahzad , Don Gilden , Randall J. Cohrs (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - March 30, 2015 Category: Research Source Type: research

Effect of repeated passaging and cell density on proliferation and differentiation potential of cord blood unrestricted somatic stem cells
Conclusion: Taken together, the above results suggest the use of USSCs at earlier passages of 5 cells/cm2 cultures if a high expansion rate of CB-USSCs is required in therapeutic strategies, while USSCs culture at 5000 cells/cm2 is the best protocol if the therapeutic target is induction of USSCs differentiation. (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Antibody-based targeting of TNF-ligands for cancer therapy
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Edwin Bremer The tumor necrosis factor (TNF) ligand and cognate TNF receptor superfamily constitute an important immunoregulatory axis pivotal for the correct execution of immune responses. TNF ligand and receptor family members among others are involved in induction of cell death in malignant cells as well as in providing co-stimulatory signals that help mount effective anti-cancer immune responses. This diverse and important regulatory role in immunity has sparked great interest in the development of TNFL/TNFR-...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Calcium efflux pump, PMCA2, in human breast tissue with lactational change and as a therapeutic target in breast cancer
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Amelia A. Peters , Wei C. Lee , Eloise Dray , Chanel E. Smart , Lynne Reid , Leonard da Silva , Sunil R. Lakhani , Sarah J. Roberts-Thomson , Gregory R. Monteith Calcium pumps and channels modulate cell proliferation and apoptosis by regulating intracellular calcium (Ca2+). The plasma membrane Ca2+ ATPase isoform, PMCA2, is a calcium efflux mechanism that extrudes Ca2+ from the cytosol into the extracellular space. PMCA2 has a restricted expression, including expression in cochlear hair cells and cerebell...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Claudin expression in animal models of IBD and human disease
In conclusion, it was shown that claudin 1, 3 and 8 expression pattern/intensity is altered in the mouse models of IBD in a same manner as observed in human biopsies from UC patients and described in patients with Crohn's disease. (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Proteomic profiling to identify markers of bacterial meningitis
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Enitan D. Carrol , L Gómez-Baena , G Laing , R Beynon Bacterial meningitis is usually fatal without treatment and prompt and accurate diagnosis coupled with the timely administration of parenteral antibiotics are necessary in order to save lives. Despite the availability of highly effective antibiotics, the complications from bacterial meningitis (such as deafness, hydrocephalus, seizures and cerebral palsy) remain high. In areas with a high incidence of human immunodeficiency virus infection, Streptococcus p...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Prognosticative Biomarker Clusters for Polycystic Kidney Disease
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Prakash Narayan , Brian Huang , Prani Paka , Itzhak D. Goldberg Polycystic kidney disease (PKD), in its autosomal recessive (AR) or autosomal dominant (AD) form, is characterized by the formation and expansion of numerous fluid-filled cysts within the kidneys. Quite often, the disease spreads to extrarenal territories including the liver. In addition to cyst formation, interstitial collagen deposition or scarring is sometimes observed in both kidney and liver. Progressive enlargement of the kidneys via replace...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research