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Urinary biomarkers for the diagnosis of urothelial bladder cancer
Publication date: Available online 18 December 2016 Source:New Horizons in Translational Medicine Author(s): Jamie J D'Costa, Douglas G Ward, Richard T Bryan Urothelial bladder cancer is a common cancer associated with considerable burden for both patients and healthcare providers alike. The majority of patients present with non-muscle-invasive bladder cancer (NMIBC) which, although not immediately life-threatening, requires appropriate initial management and long-term surveillance which is both invasive and costly. Accurate diagnostic urinary biomarkers could be transformational in this setting, yet have proved to be...
Source: New Horizons in Translational Medicine - December 17, 2016 Category: Research Source Type: research

Correlated expression analysis of genes implicated in schizophrenia: identification of putative disease-related pathways
Publication date: Available online 10 December 2016 Source:New Horizons in Translational Medicine Author(s): Erin I. Liedtke, Sirey Zhang, John A. Thompson, Stefan Sillau, Judith Gault Schizophrenia (SCZ) is a severe psychiatric disorder affecting 0.7% of the population.[1] When inadequately treated, subjects with SCZ experience symptoms that render them dysfunctional and unable to discern aspects of reality. Despite the fact that the majority of subjects with SCZ are sporadic cases and do not have a known family history of SCZ, a family history is one of the largest risk factors for developing SCZ.[2–4] A large g...
Source: New Horizons in Translational Medicine - December 9, 2016 Category: Research Source Type: research

Abstracts: Joint 2nd Annual Conference of Ziauddin University, HEC Pakistan with European Society for Translational Medicine (EUSTM) International Conference on Translational Medicine: From Discovery to Health Care1-3 February 2016, Karachi, Pakistan
Publication date: Available online 21 November 2016 Source:New Horizons in Translational Medicine Author(s): Nikhat Ahmed Siddiqui, Aamir Shahzad (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - November 20, 2016 Category: Research Source Type: research

Abstracts: 4th Annual Congress of the European Society for Translational Medicine (EUSTM-2016) 17 –20 October 2016, Prague, Czech Republic
Publication date: March 2016 Source:New Horizons in Translational Medicine, Volume 3, Issue 2 Author(s): Aamir Shahzad, Randall J. Cohrs (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - October 27, 2016 Category: Research Source Type: research

Putting the “bio” in “biotherapeutics”/Checkpoints for biosimilars/Application of biosimilars
Publication date: Available online 13 October 2016 Source:New Horizons in Translational Medicine Author(s): Juan V. Esplugues, Bruno Flamion, Lluis Puig Sanz The number of biosimilar medicines on the market is steadily increasing, due, in part, to patent expiration of several top-selling biologic medicines. These three e-learning modules discuss the basic concepts behind biosimilar medicines and highlight key regulatory considerations when using biosimilar medicines in medical practice. (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - October 13, 2016 Category: Research Source Type: research

Intelligent Biohybrid Systems for Functional Brain Repair
Publication date: Available online 12 October 2016 Source:New Horizons in Translational Medicine Author(s): Gabriella Panuccio, Marianna Semprini, Michela Chiappalone In the quest for novel neurotechnologies to defeat brain diseases, intelligent biohybrid systems have earned a privileged role among unconventional brain repair strategies. These systems are based on the functional interaction between the nervous tissue and engineered devices, the establishment of which is mediated by artificial intelligence. As novel, previously unimaginable neurotechnologies are emerging, what are the translational impact and the pract...
Source: New Horizons in Translational Medicine - October 11, 2016 Category: Research Source Type: research

4th Annual Congress of the European Society for Translational Medicine (EUSTM-2016) 17-20 October, 2016, Prague, Czech Republic
Publication date: Available online 20 September 2016 Source:New Horizons in Translational Medicine Author(s): Aamir Shahzad, Randall J. Cohrs (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - September 19, 2016 Category: Research Source Type: research

Efficacy of Pleurotus ostreatus (Jacq. Ex Fr.) P.kumm. on 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats
In this study, we have evaluated the efficacy of Pleurotus ostreatus (Jacq. Ex Fr.) P.kumm. (P. ostreatus) an edible mushroom on modulating levels of xenobiotic metabolizing enzymes, hormonal status of estrogen and progesterone receptor (ER/PR), protein expressions and histopathological analysis in 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary carcinogenesis using a rat model. DMBA was induced by single subcutaneous injection at a dosage of 25mg in 1mL vehicle. The ethanolic extract of P. ostreatus (POEet) was administered orally at a concentration of 600mg/kg bwt as pre- and post-initiation stage of treatment thro...
Source: New Horizons in Translational Medicine - July 26, 2016 Category: Research Source Type: research

Current Disease and Epidemiologic Problems: What ’s Hot?
Publication date: May–July 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 4–5 Author(s): CH Calisher Included among the many current world problems are viral diseases of considerable significance and threat. This talk could not possible cover them all but will discuss the emergence of Middle East respiratory syndrome in Saudi Arabia and nearby countries, ebolavirus hemorrhagic fever in West Africa, chikungunya in the Western Hemisphere, and the re-emergence of poliomyelitis. (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - July 20, 2016 Category: Research Source Type: research

Bardet –Biedl syndrome: A model for translational research in rare diseases
Publication date: May–July 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 4–5 Author(s): Robert M. Haws, Anthony D. Krentz, Rachel V. Stankowski, Robert D. Steiner Bardet–Biedl syndrome (BBS) is a rare, multisystemic, genetic disease and member of a group of disorders called ciliopathies. This syndrome provides a mechanistic model for ciliopathies that may also extend to common disorders with complex inheritance patterns, including diabetes mellitus and obesity. Dysregulation of signaling pathways altering the cellular response to the extracellular environment is primary to the cilio...
Source: New Horizons in Translational Medicine - July 20, 2016 Category: Research Source Type: research

Infantile spasms in early-onset Niemann –Pick disease with a novel compound heterozygous mutations in SMPD1 gene
Publication date: September 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 6–7 Author(s): Massimiliano Chetta, Anna Guacci, Francesca Rizzo, Giovanna Marchese, Francesca Felicia Operto, Alessandro Weisz, Giangennaro Coppola Niemann–Pick diseases are a group of rare autosomal recessive disorders caused by an inherited deficiency of lysosomal storage with similar clinical presentations. At least three different Niemann–Pick (NP) diseases have been described, with NPA and NPB occurring as a result of a deficiency of the acid sphingomyelinase (ASM) enzyme, while NPC as a disorder t...
Source: New Horizons in Translational Medicine - July 20, 2016 Category: Research Source Type: research

Chemotherapeutic effect of 3, 3 ′-Diindolylmethane encapsulated chitosan nanoparticles on 7, 12-Dimethylbenz (a) anthracene induced mammary cancer – A dose dependent study
Publication date: January 2016 Source:New Horizons in Translational Medicine, Volume 3, Issue 1 Author(s): Stainsloss Isabella, Sankaran Mirunalini Breast cancer is the second most prevalent cancer among women and its incidence is amplifying alarmingly. Since genetic factors are believed to account for only 10% of the reported cases, remaining the environmental factors, including diet are thought to play a significant role in predisposing breast cancer. Many bioactive compounds have been reported for their anticancer potential. One among the bioactive compound 3, 3′-Diindolylmethane (DIM) is a phytochemical posse...
Source: New Horizons in Translational Medicine - July 20, 2016 Category: Research Source Type: research

Efficacy of Pleurotus ostreatus (Jacq. Ex Fr.) P.kumm. on 7, 12-dimethylbenz (a) anthracene induced mammary carcinogenesis in female Sprague-Dawley rats
In this study, we have evaluated the efficacy of Pleurotus ostreatus (Jacq. Ex Fr.) P.kumm. (P. ostreatus) an edible mushroom on modulating levels of xenobiotic metabolizing enzymes, hormonal status of estrogen and progesterone receptor (ER/PR), protein expressions and histopathological analysis in 7, 12-dimethylbenza (a) anthracene (DMBA) induced mammary carcinogenesis using a rat model. DMBA was induced by single subcutaneous injection at a dosage of 25mg in 1mL vehicle. The ethanolic extract of P. ostreatus (POEet) was administered orally at a concentration of 600mg/kg bwt as pre and post-initiation stage of treatment t...
Source: New Horizons in Translational Medicine - July 7, 2016 Category: Research Source Type: research

Controlled delivery systems of cellulose matrix for oxytetracycline: In vitro dissolution
Publication date: Available online 25 June 2016 Source:New Horizons in Translational Medicine Author(s): Disha Mishra, Puja Khare, K. Shanker, Dhananjay K. Singh, Suaib Luqman Microfibrillated cellulose (MFC) has recently been explored as a novel nanostructured system for controlled drug delivery. The present study examines the releasing behaviour and antibacterial efficacy of cellulose (CC) and tempo-oxidized- microfibrillated cellulose (TO-MFC) loaded with oxytetracycline at three different physiological pH (2.1, 6.8 and 9.0). The releasing mechanism from cellulosic matrix was assessed using applying zero o...
Source: New Horizons in Translational Medicine - June 25, 2016 Category: Research Source Type: research

The Potential of Precision Medicine
Publication date: Available online 17 May 2016 Source:New Horizons in Translational Medicine Author(s): Dimitris Kalaitzopoulos The evolving field of Precision Medicine is revolutionizing drug discovery and healthcare delivery. In this article, we take a look at how this nascent field has already impacted drug development for targeted therapy and the widespread use of genetic testing to assist clinical decision making at point-of-care. We also examine how the interaction of people and technology plays a critical role in Precision Medicine delivery. Finally, we conclude with how Precision Medicine can bring healthcare...
Source: New Horizons in Translational Medicine - May 17, 2016 Category: Research Source Type: research