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Chemotherapeutic effect of 3, 3′-Diindolylmethane encapsulated chitosan nanoparticles on 7, 12-Dimethylbenz (a) anthracene induced mammary cancer – A dose dependent study
Publication date: January 2016 Source:New Horizons in Translational Medicine, Volume 3, Issue 1 Author(s): Stainsloss Isabella, Sankaran Mirunalini Breast cancer is the second most prevalent cancer among women and its incidence is amplifying alarmingly. Since genetic factors are believed to account for only 10% of the reported cases, remaining the environmental factors, including diet are thought to play a significant role in predisposing breast cancer. Many bioactive compounds have been reported for their anticancer potential. One among the bioactive compound 3, 3′-Diindolylmethane (DIM) is a phytochemical posse...
Source: New Horizons in Translational Medicine - May 14, 2016 Category: Research Source Type: research

Development and Characterization of Chitosan-based Antimicrobial Films Incorporated with Streptomycin Loaded Starch Nanoparticles
The objective of this study was to prepare chitosan based antimicrobial films by the incorporation of streptomycin loaded starch Nanocrystals.Different properties of this film such as swelling nature, moisture content,degradation nature and the antimicrobial activity of modified chitosan films were investigated. Drug releasing efficacy of the film was also studied. The addition of streptomycin loaded Starch nanocrystals in chitosan-gelatin film increased crystallinity of the film, lowered the swelling nature of the film to a controlled manner. Moreover the Modified chitosan based antimicrobial film showed almost 90% of Esc...
Source: New Horizons in Translational Medicine - May 14, 2016 Category: Research Source Type: research

Translational aspects in targeting the stromal tumour microenvironment: From bench to bedside
Publication date: Available online 28 March 2016 Source:New Horizons in Translational Medicine Author(s): R. Bhome, H.A. Al-Saihati, R.W. Goh, M.D. Bullock, J.N. Primrose, G.J. Thomas, A.E. Sayan, A.H. Mirnezami Solid tumours comprise, not only malignant cells but also a variety of stromal cells and extracellular matrix proteins. These components interact via an array of signalling pathways to create an adaptable network that may act to promote or suppress cancer progression. To date, the majority of anti-tumour chemotherapeutic agents have principally sought to target the cancer cell. Consequently, res...
Source: New Horizons in Translational Medicine - March 28, 2016 Category: Research Source Type: research

Infantile spasms in early-onset Niemann–Pick disease with a novel compound heterozygous mutations in SMPD1 gene
Publication date: September 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 6–7 Author(s): Massimiliano Chetta, Anna Guacci, Francesca Rizzo, Giovanna Marchese, Francesca Felicia Operto, Alessandro Weisz, Giangennaro Coppola Niemann–Pick diseases are a group of rare autosomal recessive disorders caused by an inherited deficiency of lysosomal storage with similar clinical presentations. At least three different Niemann–Pick (NP) diseases have been described, with NPA and NPB occurring as a result of a deficiency of the acid sphingomyelinase (ASM) enzyme, while NPC as a disorder t...
Source: New Horizons in Translational Medicine - February 2, 2016 Category: Research Source Type: research

Scientific abstracts presented at the 5th International Convention of Association of Pharmacy Professionals: Redesigning Pharmacy Education and Regulations for Translational Drug Research in India, hosted at Anna University, Centre for Excellence in Nanobio Translational Research, Bharathidasan Institute of Technology Campus, Tiruchirappalli, Tamil Nadu, India, 22nd–23rd January, 2016
Publication date: Available online 21 January 2016 Source:New Horizons in Translational Medicine Author(s): Isabella Stainsloss, Mirunalini Sankaran (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - January 22, 2016 Category: Research Source Type: research

Abstracts: 3rd Annual Congress of the European Society for Translational Medicine (EUSTM-2015), 1–4 September, 2015, Vienna, Austria
Publication date: Available online 10 December 2015 Source:New Horizons in Translational Medicine Author(s): Aamir Shahzad, Randall J Cohrs (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - January 14, 2016 Category: Research Source Type: research

Viral strategies to modulate NKG2D-ligand expression in Human Cytomegalovirus infection
Publication date: Available online 1 January 2016 Source:New Horizons in Translational Medicine Author(s): Hugh Reyburn, Gloria Esteso, Omodele Ashiru, Vales-Gomez Mar Human cytomegalovirus is a paradigm for studies of viral strategies of immune evasion. In particular, the virus has developed multiple mechanisms for evasion of immune surveillance by lymphocytes expressing the activating receptor NKG2D. The human genome encodes several ligands able to bind NKG2D and in this article we review and discuss what is known about the various viral proteins and micro RNAs that act to minimise the recognition of the infe...
Source: New Horizons in Translational Medicine - January 14, 2016 Category: Research Source Type: research

Infantile spasms in early-onset Niemann-Pick disease with a novel compound heterozygous mutations in SMPD1 gene
Publication date: Available online 1 January 2016 Source:New Horizons in Translational Medicine Author(s): Massimiliano Chetta, Anna Guacci, Francesca Rizzo, Giovanna Marchese, Francesca Felicia Operto, Alessandro Weisz, Giangennaro Coppola Niemann-Pick diseases are a group of rare autosomal recessive disorders caused by an inherited deficiency of lysosomal storage with similar clinical presentations. At least three different Niemann-Pick (NP) diseases have been described, with NPA and NPB occurring as a result of a deficiency of the acid sphingomyelinase (ASM) enzyme, while NPC as a disorder that cause m...
Source: New Horizons in Translational Medicine - January 14, 2016 Category: Research Source Type: research

Preclinical Characterization of Eleven New Cys-Pegylated hGH Mutants
In conclusion, even when it is directed to residues supposed to have a marginal role in the activity of this hormone, 20KDa pegylation has detrimental effect on hGH bioactivity. These effects may be counterbalanced by the increase in half-life as it happens in pegylated Ile138Cys-hGH that could represent a promising new long-acting hGH derivative. Focal points • Bedside Current therapy of GH deficiency still has the important limitation of being delivered by daily subcutaneous injections and this reduces the compliance of the small pediatric patients. There is, therefore interest in developing long-acting GH de...
Source: New Horizons in Translational Medicine - January 14, 2016 Category: Research Source Type: research

Abstracts: 3rd Annual Congress of the European Society for Translational Medicine (EUSTM-2015) 1-4 September, 2015, Vienna, Austria.
Publication date: Available online 10 December 2015 Source:New Horizons in Translational Medicine Author(s): Aamir Shahzad, Randall J Cohrs (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - December 11, 2015 Category: Research Source Type: research

Targeting Inflammatory Responses to Streptococcus pneumoniae
Publication date: Available online 1 October 2015 Source:New Horizons in Translational Medicine Author(s): Jimstan Periselneris, Ricardo J. José, Jeremy Brown . Streptococcus pneumoniae is a common cause of infectious morbidity and mortality, causing otitis media, pneumonia, septicaemia, and meningitis. The host inflammatory response is required for clearance of bacteria, but excessive inflammation can mediate bystander tissue damage. The host response is complex; involving initial recognition by pattern recognition receptors, clearance by tissue macrophages and the institution of an inflammatory response. This...
Source: New Horizons in Translational Medicine - October 2, 2015 Category: Research Source Type: research

Lipid and Sterol Gene Sequence Variation in Autism and Correlates with Neurodevelopmental Status: A Pilot Study
Conclusions Variants occurred in 355 total genomic positions, 53 of which were not previously annotated as variant positions in either dbSNP or the 1000 Genomes Project’s variant annotation. Of these 355 variants, 169 were nonsynonymous (31 were novel). The total number of variants observed in the exons of captured regions of an individual participant ranged from 88 to 117; novel variants ranged from four to 10 per participant, while nonsynonymous variants ranged from 36 and 51 per participant. The total number of nonsynonymous variants per subject was significantly associated with neurodevelopmental function. Further, s...
Source: New Horizons in Translational Medicine - September 25, 2015 Category: Research Source Type: research

Interferon response in a hamster model of arenavirus hemorrhagic disease
We examined the pathogenesis of PIRV infection by clinical and molecular methods, with a focus on gene expression of the antiviral type I interferon response using RNA-Seq. More than 3,000 genes were differentially expressed in the livers of infected hamsters, of which 86 are involved with antiviral responses. Several of these genes participate in apoptosis and autophagy, which may suggest a mechanism of pathogenesis observed in damaged livers. (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - September 13, 2015 Category: Research Source Type: research

Generating new prions by targeted mutation or segment duplication
Publication date: May–July 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 4–5 Author(s): C Hendrich, KR Paul, A Waechter, M Harman, ED. Ross Prions are infectious agents composed entirely of protein. Prion activity results from the conversion of soluble proteins into an insoluble, self-templating amyloid form. Nine different amyloid-based prions have been identified in yeast. All but one contain a glutamine/asparagine (Q/N) rich region that is responsible for prion activity. Similar Q/N-rich regions are over-represented in eukaryotic genomes. In humans, aggregation-causing mutations ...
Source: New Horizons in Translational Medicine - September 13, 2015 Category: Research Source Type: research

Structure-based Engineering of Sabin 2 Poliovirus Polymerase to Alter Replication Fidelity
Publication date: May–July 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 4–5 Author(s): A Keith, S Campagnola, O. Peersen Picornaviruses cause a wide range of ailments, including myocarditis, poliomyelitis, and vesicular lesion type diseases. Excellent vaccines exist for several of them, and the development of the live-attenuated oral polio vaccine (OPV) provided an efficient and cost-effective avenue for successful poliovirus eradication in the majority of the world. However, one hurdle for developing successful live-attenuated vaccines lies with the viral RNA-dependent-RNA-polymerase ...
Source: New Horizons in Translational Medicine - September 13, 2015 Category: Research Source Type: research