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Animal models in translational medicine: Validation and prediction
Publication date: September 2014 Source:New Horizons in Translational Medicine, Volume 2, Issue 1 Author(s): Tinneke Denayer , Thomas Stöhr , Maarten Van Roy Despite large investments in drug development, the overall success rate of drugs during clinical development remains low. One prominent explanation is flawed preclinical research, in which the use and outcome of animal models is pivotal to bridge the translational gap to the clinic. Therefore, the selection of a validated and predictive animal model is essential to address the clinical question. In this review, the current challenges and limitations of animal ...
Source: New Horizons in Translational Medicine - November 4, 2014 Category: Research Source Type: research

Systems Patientomics: The virtual in-silico patient
Publication date: September 2014 Source:New Horizons in Translational Medicine, Volume 2, Issue 1 Author(s): D.V. Dimitrov The integration of clinical and molecular sciences with advanced engineering sciences is moving the world towards a new generation of life science where physiological and pathological information from the living human body can be quantitatively described in silico via biocomputing across multiple scales of time and size and through diverse hierarchies of organization – from molecules to cells and organs to individuals. The development of the Virtual Patient will change conventional medicine, whi...
Source: New Horizons in Translational Medicine - November 4, 2014 Category: Research Source Type: research

New horizons in translational medicine
Publication date: September 2014 Source:New Horizons in Translational Medicine, Volume 2, Issue 1 Author(s): Aamir Shahzad , Randall J. Cohrs (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - November 4, 2014 Category: Research Source Type: research