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Novel approaches for the supportive extracorporeal therapy of sepsis: Towards personalized treatment
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Viktoria Weber Sepsis and sepsis-associated multiple organ failure are associated with extensive tissue damage caused by over-activation of the innate immune system and by the excessive release of inflammatory mediators. The development of targeted therapies for sepsis remains a major challenge due to the complex network of inflammatory mediators involved in the septic process. Early detection and timely therapeutic intervention are crucial for improved outcome of patients with sepsis. Currently however, the diag...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Rapid salive test for varicella zoster virus
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Randall J. Cohrs Varicella zoster virus (VZV) is a ubiquitous human herpesvirus typically causing childhood varicella (chickenpox) at which time a life-long latent infection is established in ganglionic neurons throughout the neuraxis. Reactivation of latent virus, typically in the elderly and immunocompetent usually causes zoster (shingles) but can also result in serious neurologic disease. In cases of vasculopathy, meningoencephalitis and myelitis where VZV is suspected, diagnosis requires detection of virus DN...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Anti-tumor effects of the human monoclonal anti-nuclear antibody on the HEp-2 cells
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Fengmin Zhang , Yujun Li , Yong Fang , Wenping Kao , Wuqi Song Function of autoantibodies from patients with autoimmune diseases in malignancies development is not clear yet. It has been reported that a cell-penetrating lupus autoantibody, 3E10, which was isolated from a mouse model of systemic lupus erythematosus (SLE), has been a potential targeted therapy for DNA-repair deficient malignancies. We have got four human monoclonal antinuclear antibodies from patients with autoimmune disease, 3B5, 3C1, 3E8 and ...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

The changing face of epidemiology of systemic fungal infections
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Cornelia Lass-Flörl Invasive fungal diseases (IFDs) are an increasingly common complication in critically ill patients in Europe and are frequently fatal. Because of changes in treatment strategies and the increased use of antifungal prophylaxis, the epidemiology of IFDs has changed substantially in recent years and infections due to Candida species are no longer the majority in many institutions. In contrast, the emergence of non-Candida IFDs such as aspergillosis, ucrmycosis and fusariosis has increased. Rates...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Mass spectrometry-based quantification of malignant biliary stenosis biomarkers in human bile.
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Annarita Farina , Annie Adrait , Jean-Marc Dumonceau , Myriam Delhaye , Jean-Louis Frossard , Yohann Couté The differential diagnosis of biliary stenosis is a critical problem for gastroenterologists. An early identification of malignant lesions would enable the rapid resort to surgical resection which currently represents the only potentially curative option. Unfortunately, the diagnostic value of all available methods (e.g. imaging technics, standard serum biomarkers) is limited by relatively poor accurac...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

DNA-methylation and autoantibodies based cancer diagnosis from body fluids
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Christa Noehammer , Matthias Wielscher , Johana Fuchs-Luna , Istvan Gyurjan , Manuela Hofner , Ulrike Kegler , Linda Stoeger , Christian Singer , Friedrich Längle , Johann Hofbauer , Andrea Gsur , Rolf Ziesche , Klemens Vierlinger , Andreas Weinhaeusel Special focus and aim of our research activities at AIT, the Austrian Institute of Technology, is to define reliable biomarkers suitable for early and non-invasive disease diagnosis from body fluids such as serum/plasma and saliva. Along a selection o...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Modeling and simulation the conduit connecting translational medicine with portfolio management
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Parviz Ghahramani Translational medicine science and the volume of information generated in this field have grown exponentially in the last decade and continue to grow faster every day. This has generated a huge amount of data. The application of Modeling and Simulation (M&S) in drug development has also grown in the last two decades, but mostly has been limited to analysis of single studies or to analysis of pooled data from several studies. Such application traditionally has been used either to support ...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Restoring the function of the glutamate-nitric oxide –cGMP pathway by treatments acting on different brain targets restores cognitive function in rats with minimal hepatic encephalopathy
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Vicente Felipo , Marta Llansola , Carmina Montoliu , Ana Agusti , Vicente Hernandez-Rabaza , Andrea Cabrera-Pastor , Alma Orts , Raquel Garcia-Garcia , Belen Gomez-Gimenez Chronic liver disease (e.g. cirrhosis) affects brain function. There is a high incidence of mild cognitive impairment and psychomotor slowing in patients with cirrhosis. This condition, known as minimal hepatic encephalopathy (MHE) affects more than 2 million people in the European Union and has serious health, social and economic conse...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Preventive handling of drug nephrotoxicity with antioxidant cotherapies: Preclinical studies and clinical perspectives
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Ana Isabel Morales Martín Worldwide, nephrotoxicity poses a considerable health and economic burden. Nearly 25% of the top 100, most used drugs in intensive care units are potentially nephrotoxic. Moreover, nephrotoxicity causes 10-20% of the acute renal failure cases (ARF). ARF is a very serious condition with high incidence and mortality rate, which is estimated at approximately 50% of the cases despite dialysis application, especially within critically ill patients. Mortality increases to 80% when ARF courses...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Other applications of medical microwaves – Breast tumour classification
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Raquel Conceição This talk addresses the development of imaging techniques for the early detection of breast cancer, based on Ultra Wideband (UWB) radar, a promising emerging technology that exploits the dielectric contrast between normal and tumour tissues at microwave frequencies. Of particular interest in this work are issues related to techniques for classification of potential breast tumours into benign and malignant. This is particularly important given the results from recent studies of the dielectric pr...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Hyperthermia applications at microwave frequencies
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Jan Vrba Short introduction to microwave hyperthermia from the point of view of biology and physics will be given firstly. The physical basis of microwave thermotherapy for cancer treatment and for other medical microwave therapeutic purposes (e.g. in cardiology, urology, surgery, physiotherapy, etc.) will be described in this talk. Different kinds of hyperthermia clinical applications will be mentioned (i.e. local, deep local, regional and intracavitary treatment). Different physical and technological approach t...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Microwaves for medical imaging: Some possible pathways for an accelerated progress towards clinical practice
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Lorenzo Crocco The talk will start from a brief review of the physical basis of microwave imaging for medical diagnostics and of the challenges that have to be faced in this technology, to present three areas which are possibly the most promising ones for a fruitful application of microwave imaging in the medical arena. The first one is the monitoring of brain injuries, which is a topic of increasing importance for its impact on the European health system in the ageing society. In particular, it will be discussed...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Satellite symposium: Emerging role of microwave imaging technology (organized by the biomedicine and molecular biosciences COST action TD1301) Microwave Imaging for Breast Cancer Detection
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Martin O’Halloran Breast cancer is the most common cancer in women worldwide, with nearly 1.7 million new cases diagnosed in 2012. This represents about 12% of all new cancer cases and 25% of all cancers in women. The current standard method for detecting non-palpable early stage breast cancer is X-ray mammography. Despite the fact that X-rays provide high-resolution images at low radiation doses, its limitations are well documented. In the U.S., up to 75% of all malignancies identified by X-ray mammography are...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Three-dimensional normal human neural progenitor tissue-like assemblies: A model for persistent Varicella-zoster virus infection and platform to study oxidate stress and damage in multiple hit scenarios
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Thomas J. Goodwin , M McCarthy , N. Osterrieder , R.J. Cohrs , B.B. Kaufer The environment of space results in a multitude of challenges to the human physiology that present barriers to extended habitation and exploration. Over 40 years of investigation to define countermeasures to address space flight adaptation has left gaps in our knowledge regarding mitigation strategies partly due to the lack of investigative tools, monitoring strategies, and real time diagnostics to understand the central causative agen...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research

Disease systems modeling for discovery of mechanistic biomarkers
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Erfan Younesi The use of biomarkers is becoming increasingly integral to to the contemporary practice of medicine and continues to play a central role in preventive, predictive and personalized medicine. However, the limited number of FDA-approved, in use biomarkers, on one hand, and an increasing number of published potential biomarkers, on the other hand, calls for an accelerated approach to translating biomarker research to clinical application. In this talk, I introduce novel concept of "Biomarker-guided Mech...
Source: New Horizons in Translational Medicine - February 8, 2015 Category: Research Source Type: research