Protein aggregation and Arfaptin2: A novel therapeutic target against neurodegenerative diseases

Publication date: September 2014 Source:New Horizons in Translational Medicine, Volume 2, Issue 1 Author(s): Aida M. Mohammedeid , Vera Lukashchuk , Ke Ning Therapeutic targets for neurodegenerative conditions are constantly emerging. Diseases such as amyotrophic lateral sclerosis and Huntington׳s disease are multifactorial and involve dysfunction of various cellular pathways. Protein aggregate formation is one of the crucial pathological signs of cellular dysfunction, and is characteristic of many neurodegenerative conditions. Proteins recruited to these aggregates are thought to play a role in formation of the pathogenic inclusions. This review aims at exploring the current evidence for protein aggregation and the role for Arfaptin2, as a candidate factor contributing to the formation of aggresomes and a potential therapeutic target in motor neuron disease. Focal points • Bedside Understanding the multifactorial nature of the pathogenesis of neurodegenerative diseases will contribute to the research into the therapeutic targets of the disease, allowing more factors to be discovered in patients affected by the debilitating disorders of the nervous system. • Benchside Collaborative efforts in investigating the causes and pathways of neurodegeneration are likely to increase the chance of discovering novel therapy approaches that may be utilised in more than one type of neurodegenerative disorders. • Industry The application of the novel therapeutic tar...
Source: New Horizons in Translational Medicine - Category: Research Source Type: research