Communication Skills and Decision Making for Elderly Patients With Advanced Kidney Disease: A Guide for Nephrologists
As we all know, elderly patients comprise the most rapidly growing population initiating dialysis therapy. This review provides nephrologists with the palliative skills that can help care for this patients and aid in dialysis treatment decisions as well as decisions regarding overall goals of care.
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CKD in Elderly Patients Managed without Dialysis: Survival, Symptoms, and Quality of Life
The Ethics of End-of-Life Care for Patients with ESRD
Factors influencing patient choice of dialysis versus conservative care to treat end-stage kidney disease (Source: Nephrology Now)
Source: Nephrology Now - May 29, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Nephrology Source Type: research
Autosomal Dominant Polycystic Kidney Disease: Core Curriculum 2016
This core curriculum is a comprehensive overview on ADPKD that should prove to be valuable to both trainee and consultant physicians.
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Home Hemodialysis, Daily Hemodialysis, and Nocturnal Hemodialysis: Core Curriculum 2009
Hypertension
Update on Peritoneal Dialysis: Core Curriculum 2016. (Source: Nephrology Now)
Source: Nephrology Now - May 29, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: AJKD Core Curriculum Clinical Nephrology Polycystic Kidney Disease Source Type: research
Controversies Regarding Lipid Management and Statin Use for Cardiovascular Risk Reduction in Patients With CKD
It is known that patients with chronic kidney disease are at increased risk of death from cardiovascular disease. This review nicely addresses the identification and management of lipid levels in patients with CKD and discusses the controversies regarding testing and treatment of lipid levels in this population.
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Metformin in Patients With Type 2 Diabetes and Kidney Disease: A Systematic Review
Asymmetrical Dimethylarginine Is Associated with Renal and Cardiovascular Outcomes and All-cause Mortality in Renal Transplant Recipients
Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated s...
Source: Nephrology Now - May 29, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Nephrology Source Type: research
The Effect of Erythropoietin-Stimulating Agents on Health-Related Quality of Life in Anemia of Chronic Kidney Disease: A Systematic Review and Meta-analysis
This meta-analysis and systematic review of 17 studies showed that higher hemoglobin targets did not result in statistically or clinically significant differences in SF-36 or KDQ domains. Furthermore, HRQOL were further attenuated in studies at low risk of bias and in subgroups of dialysis patients.
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Superior survival of high transporters treated with automated versus continuous ambulatory peritoneal dialysis
Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial.
Pregnancy Outcomes in Women with Chronic Kidney Disease:...
Source: Nephrology Now - May 29, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Anemia Clinical Nephrology Source Type: research
Update in Nephrology and Hypertension: Evidence Published in 2015
This article nicely summarizes the clinically relevant evidence published in the literature for 2015.
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Update in Nephrology: Evidence Published in 2011
Vasopressin Antagonists
What’s new in hypertension 2010? (Source: Nephrology Now)
Source: Nephrology Now - May 29, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Nephrology Educational Resource Source Type: research
Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury The ELAIN Randomized Clinical Trial
This single-center randomized clinical trial of 231 critically ill patients with AKI KDIGO stage 2 looked at early (within 8 hours of diagnosis of KDIGO stage 2; n = 112) or delayed (within 12 hours of stage 3 AKI or no initiation; n = 119) initiation of RRT. The results show that early initiation of RRT significantly reduced 90-day mortality (39.3% vs 54.7%). More patients in the early group recovered renal function by day 90 (53.6% vs 38.7%) in the delayed group. Furthermore, duration of RRT and length of hospital stay were significantly shorter in the early group than in the de...
Source: Nephrology Now - May 29, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Clinical Trial Results Hemodialysis Source Type: research
Bioengineered human acellular vessels for dialysis access in patients with end-stage renal disease: two phase 2 single-arm trials
This phase 2 trial looked at bioengineered human acellular vessel as an option for dialysis access in 60 patients that were not candidates for arteriovenous fistulas. The results show that onne vessel became infected during 82 patient-years of follow-up. There were no vessels with dilatation and there was rarely any post-cannulation bleeding. At 12 months, 28% (17–40) had primary patency, 38% (26–51) had primary assisted patency, and 89% (74–93) had secondary patency. These result certainly warrant further study with a randomized controlled trial.
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Use of Aspirin Associates with Longer Primary Patency of...
Source: Nephrology Now - May 29, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Hemodialysis Vascular Access Source Type: research
Multinational Assessment of Accuracy of Equations for Predicting Risk of Kidney Failure: A Meta-analysis.
Thirty-one cohorts participating in the CKD Prognosis Consortium, including 721,357 participants with CKD stages 3 to 5 in more than 30 countries spanning 4 continents, were studied to evaluate the accuracy of the kidney failure risk equations. During a median follow-up of 4 years of 721,357 participants with CKD, 23,829 cases kidney failure were observed. The original risk equations achieved excellent discrimination across all cohorts (overall C statistic, 0.90; 95% CI, 0.89-0.92 at 2 years; C statistic at 5 years, 0.88; 95% CI, 0.86-0.90); discrimination in subgroups by age, race, and diabetes status was simil...
Source: Nephrology Now - March 23, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Nephrology General Nephrology Source Type: research
Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis.
This systematic review and meta-analysis of 19 trials included 44,989 participants, with 2496 major cardiovascular events were recorded during a mean 3·8 years of follow-up. Patients in the more intensive blood pressure-lowering treatment group had mean blood pressure levels of 133/76 mm Hg, compared with 140/81 mm Hg in the less intensive treatment group. Intensive blood pressure-lowering treatment achieved RR reductions for major cardiovascular events (14% [95% CI 4-22]), myocardial infarction (13% [0-24]), stroke (22% [10-32]), albuminuria (10% [3-16]), and retinopathy progression (19% [0-34]). Howe...
Source: Nephrology Now - March 23, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: General Nephrology Hypertension Internal Medicine for Nephrologists Source Type: research
Update on Peritoneal Dialysis: Core Curriculum 2016.
This is an update on peritoneal dialysis with this new core curriculum.
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General Medical Care of the Dialysis Patient: Core Curriculum 2013.
Peritoneal Dialysis-Related Infections Recommendations: 2010 Update | NOW FREE FULL TEXT
Hemodialysis: core curriculum 2014. (Source: Nephrology Now)
Source: Nephrology Now - March 23, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: AJKD Core Curriculum Clinical Nephrology Source Type: research
Vascular Access Type and Patient and Technique Survival in Home Hemodialysis Patients: The Canadian Organ Replacement Register.
This registry-based retrospective observational cohort study assessed 1217 incident HHD patients in The Canadian Organ Replacement Register who had information for vascular access type (CVC vs AV access) within the first year of HHD therapy initiation. The results showed that AV access use (n=694) was associated with lower risk for the composite event of death and technique failure (490 events; adjusted HR, 0.78; 95% CI, 0.64-0.94) and lower adjusted all-cause mortality (129 deaths; adjusted HR, 0.63; 95% CI, 0.43-0.91) while the risk for technique failure was not statistically significant.
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Per...
Source: Nephrology Now - March 23, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Trial Results Vascular Access Source Type: research
Modality of RRT and Recovery of Kidney Function after AKI in Patients Surviving to Hospital Discharge.
This retrospective cohort study examined 4738 patients with KDIGO stage 3 AKI admitted to intensive care units from 2000 to 2008 who received RRT for AKI and survived to hospital discharge or 90 days. There was no significant difference in hazards for nonrecovery or reasons for nonrecovery (mortality or ESRD) with intermittent hemodialysis versus continuous RRT.
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Trends in In-Hospital Cardiopulmonary Resuscitation and Survival in Adults Receiving Maintenance Dialysis
Trends in In-Hospital Cardiopulmonary Resuscitation and Survival in Adults Receiving Maintenance Dialysis
Outcomes of In-Hospital Cardiop...
Source: Nephrology Now - March 23, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Clinical Nephrology Clinical Trial Results Source Type: research
The Native Kidney Biopsy: Update and Evidence for Best Practice.
This review nicely summarizes kidney biopsy indications, techniques and complications.
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The Tumor Lysis Syndrome
Perioperative acute kidney injury: risk factors, recognition, management, and outcomes
Metformin in Patients With Type 2 Diabetes and Kidney Disease: A Systematic Review (Source: Nephrology Now)
Source: Nephrology Now - March 23, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Nephrology Educational Resource Source Type: research
Sevelamer Versus Calcium-Based Binders for Treatment of Hyperphosphatemia in CKD: A Meta-Analysis of Randomized Controlled Trials
This meta-analysis included 25 studies with a total of 4770 participants, of which 88% were on hemodialysis. The results show that for patients with CKD stages 3-5 using sevelamer have lower all-cause mortality compared with those using calcium based binders. However, due to the lack of placebo-controlled studies, the benefit of phosphate binders for patients with CKD stages 3-5 and not on dialysis remain unclear.
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Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis.
The demise of calcium-ba...
Source: Nephrology Now - March 23, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Bone Mineral Metabolism Clinical Trial Results Vascular Disease/Calcification Source Type: research
Comparison of low-dose intravenous cyclophosphamide with oral mycophenolate mofetil in the treatment of lupus nephritis
This study randomized patients with LN (class III, IV, or V) to receive induction with low-dose CYC or oral MMF with the exclusion of patients with crescentic LN, a serum creatinine over 265 μmol/l, and neurological or pulmonary lupus were excluded. Maintenance therapy with azathioprine and low-dose corticosteroid was started at end of induction therapy. The complete remission rate was 50% in CYC and 54% in MMF group, adverse effect profile was similar except for more gastrointestinal symptoms in the MMF group.
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Mycophenolate versus Azathioprine as Maintenance Therapy for Lupus Nephritis
Efficacy of Remissio...
Source: Nephrology Now - March 23, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury General Nephrology Glomerulonephritis Source Type: research
