Evidence-Based Cardiology in Hemodialysis Patients.
This paper reviews RCTs to evaluate management of cardiovascular disease in hemodialysis patients.
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Systematic Review: Vitamin D and Calcium Supplementation in Prevention of Cardiovascular Events
Nutritional Considerations in Kidney Disease: Core Curriculum 2010
Cholesterol Lowering, Cardiovascular Diseases, and the Rosuvastatin – JUPITER Controversy A Critical Reappraisal (Source: Nephrology Now)
Source: Nephrology Now - December 22, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Hemodialysis Review Vascular Disease/Calcification Source Type: research
Screening, Monitoring, and Treatment of Stage 1 to 3 Chronic Kidney Disease: A Clinical Practice Guideline From the Clinical Guidelines Committee of the American College of Physicians.
This ACP guideline recommends a) against screening for chronic kidney disease in asymptomatic adults without risk factors for CKD, b) against testing for proteinuria in adults currently taking an ACEi or ARB, c) using an ACEi or ARB in patients with hypertension and CKD, and d) using a statin to manage elevated LDL in patients with chronic kidney disease.
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Persistent Asymptomatic Isolated Microscopic Hematuria in Israeli Adolescents and Young Adults and Risk for End-Stage Renal Disease
Lipid-Lowering Therapy in Persons With Chronic Kidney Disease: A Systematic Review and Meta-analysis.
Effects of intensive blood pressure...
Source: Nephrology Now - December 22, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Hypertension RAS Blockade Source Type: research
Diet and Kidney Disease in High-Risk Individuals With Type 2 Diabetes Mellitus
This observational study of the ONTARGET type 2 diabetic patient population showed that a healthy diet (consisting of more than 3 servings of fruit per week) and a moderate intake of alcohol may decrease the incidence or progression of CKD in this population. Interestingly, sodium and normal protein intake were not associated with CKD.
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Fatal and Nonfatal Outcomes, Incidence of Hypertension, and Blood Pressure Changes in Relation to Urinary Sodium Excretion
A Systematic Review on Steroid Withdrawal Between 3 and 6 Months After Kidney Transplantation
Sodium Intake, ACE Inhibition, and Progression to ESRD (Source: Nephrology Now)
Source: Nephrology Now - December 22, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Nephrology Diabetes Source Type: research
Citrate Versus Heparin Lock for Hemodialysis Catheters: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
This meta-analysis suggests that an antimicrobial-containing citrate lock is better than heparin lock for prevention of catheter-related infection, while citrate alone fails to show a similar advantage. As compared to heparin, citrate locking showed a reduction in bleeding episodes.
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Prevention of Dialysis Catheter Malfunction with Recombinant Tissue Plasminogen Activator
Coiled Versus Straight Peritoneal Dialysis Catheters: A Randomized Controlled Trial and Meta-analysis
Mycophenolate mofetil is as efficacious as, but safer than, cyclophosphamide in the treatment of proliferative lupus nephritis: a meta-analysis and met...
Source: Nephrology Now - December 22, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Hemodialysis Vascular Access Source Type: research
Use of phosphate-binding agents is associated with a lower risk of mortality
In this mulitcenter, observational, prospective study of stage 5 CKD patients on dialysis, the use of phosphate-binding agents was shown to lower all-cause and cardiovascular mortality by 29% and 22% respectively. All agents proved to be beneficial except aluminum salts. There interesting findings need to be confirmed in randomized clinical trials.
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Effects of Antiplatelet Therapy on Mortality and Cardiovascular and Bleeding Outcomes in Persons With Chronic Kidney Disease: A Systematic Review and Meta-analysis
High-Efficiency Postdilution Online Hemodiafiltration Reduces All-Cause Mortality in Hemodialysis Patients
A Ran...
Source: Nephrology Now - December 22, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Bone Mineral Metabolism Chronic Kidney Disease Clinical Nephrology Hemodialysis Source Type: research
No independent association of serum phosphorus with risk for death or progression to end-stage renal disease in a large screen for chronic kidney disease
Contrary to the generally held belief, this study showed that when adjusted for potential confounders, serum phosphorus was not independently found to be associated with a risk of death or progression to ESRD in the group of over 10 000 patients with eGFRs < 60 ml/min.
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Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study
Persistent Asymptomatic Isolated Microscopic Hematuria in Israeli Adolescents and Young Adults and Risk for End-Stage Renal Disease
Superior survival of high transporters treated with automated versus continuous ambulatory peritoneal dialys...
Source: Nephrology Now - December 22, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Bone Mineral Metabolism Chronic Kidney Disease Clinical Nephrology General Nephrology Source Type: research
Efficacy of Remission-Induction Regimens for ANCA-Associated Vasculitis
This randomized trial compared rituximab with cyclophosphamide followed by azathioprine in severe ANCA-associated vasculitis. This noninferiority trial showed that there was no difference at 18 months for the induction and maintenance of remissions between groups.
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Efficacy of Remission-Induction Regimens for ANCA-Associated Vasculitis
Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody—associated vasculitis. (Source: Nephrology Now)
Source: Nephrology Now - December 22, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Nephrology Clinical Trial Results Glomerulonephritis Vasculitis Source Type: research
A single-blind randomized controlled trial to evaluate the effect of 6 months of progressive aerobic exercise training in patients with uraemic restless legs syndrome
This small single-center study showed that a 6-month intradialytic progressive exercise training program reduces severity of restless leg syndrome in HD patients.
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Switch to a Sirolimus-Based Immunosuppression in Long-Term Renal Transplant Recipients: Reduced Rate of (Pre-)Malignancies and Nonmelanoma Skin Cancer in a Prospective, Randomized, Assessor-Blinded, Controlled Clinical Trial
The histological development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation
Survival in daily home hemodialysis and matched thrice-weekly in-center hemodialysis patients. (Source: Nephrology Now)
Source: Nephrology Now - September 8, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Hemodialysis Source Type: research
The Pathogenesis of Lupus Nephritis
This review goes into extensive detail on the pathogenesis of lupus nephritis and provides the rationale for treatment.
Full text kindly provided by the American Society of Nephrology.
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Graft Loss Due to Recurrent Lupus Nephritis in Living-Related Kidney Donation
Updates on the Treatment of Lupus Nephritis
Enzyme Replacement Therapy and Fabry Nephropathy (Source: Nephrology Now)
Source: Nephrology Now - September 8, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Lupus Review Source Type: research
Risks and benefits of intensive blood pressure lowering in patients with type 2 diabetes
This review discusses the basis for the blood pressure target of < 130/80 mm Hg for patients with hypertension and diabetes.
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Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial.
Systematic Review: Blood Pressure Target in Chronic Kidney Disease and Proteinuria as an Effect Modifier
Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus (Source: Nephrology Now)
Source: Nephrology Now - September 8, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Diabetes Hypertension Source Type: research
Effects of intensive blood pressure lowering on the progression of chronic kidney disease: a systematic review and meta-analysis
In patient with chronic kidney disease, this meta-analysis identified a 27% reduction (HR 0.73, 95% CI 0.62–0.86) in ESRD with intensive blood pressure lowering <130/80, whereas no effect was seen in patients without proteinuria. The accompanying editorial “Blood pressure targets in chronic kidney disease: Does proteinuria dictate how low we go?” discusses the interpretation of these findings.
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Pediatrics: Blood pressure target for renoprotection in children
Intensive Blood-Pressure Control in Hypertensive Chronic Kidney Disease
Systematic Review: Blood Pressure Target in Chronic Kidney Disease and Prote...
Source: Nephrology Now - September 8, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Hypertension Source Type: research
Use of Antihypertensive Medications and Breast Cancer Risk Among Women Aged 55 to 74 Years
This case-control study identified an association between >10 years of calcium-channel blockers use and a higher risk of ductal breast cancer. The associated editorial Calcium-Channel Blockers and Breast Cancer: A Hypothesis Revived discusses how this finding may be interpreted.
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Treatment of Kidney Transplant Recipients With ACEi/ARB and Risk of Respiratory Tract Cancer: A Collaborative Transplant Study Report
Antihypertensives for Kidney Transplant Recipients: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Androgen Deprivation Therapy and Risk of Acute Kidney Injury in Patients With Prostate Ca...
Source: Nephrology Now - September 8, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Hypertension Internal Medicine for Nephrologists Source Type: research
Glomerular diseases seen with cancer and chemotherapy: a narrative review
This review describes the association of glomerular diseases in the context of solid tumors, hematological malignancies, stem cell transplantation, and chemotherapeutic agents. It also discusses the intricacies of diagnosing and managing these disorders.
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Podocyte disorders: core curriculum 2011
Antiplatelet Therapy in the Management of Cardiovascular Disease in Patients with CKD: What Is the Evidence?
Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials. (Source: Nephrology Now)
Source: Nephrology Now - August 23, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Nephrology General Nephrology Review Source Type: research
Long-term follow-up of patients with severe ANCA-associated vasculitis comparing plasma exchange to intravenous methylprednisolone treatment is unclear
This longer term follow-up of PLEX for the treatment of ANCA-associated vasculitis in patients with severely impaired renal function are disappointing. The data suggest that PLEX does not significantly benefit these patients. Current trials are ongoing as to the role of PLEX in ANCA-associated vasculitis.
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Efficacy of Remission-Induction Regimens for ANCA-Associated Vasculitis
Similar Outcomes for Canadian Renal Transplant Recipients Followed Up in Transplant Centers and Satellite Clinics
Kidney and Recipient Weight Incompatibility Reduces Long-Term Graft Survival (Source: Nephrology Now)
Source: Nephrology Now - August 23, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Trial Results Glomerulonephritis Source Type: research
Role of Vaptans in the Management of Hyponatremia
In order to use vasopressin receptor antagonists safely, one requires a comprehensive understanding of their indications and contraindications. This review provides an in-depth look at vaptans and their role in the management of euvolemic and hypervolemic hyponatremia.
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Therapeutic Strategies for Heart Failure in Cardiorenal Syndromes
Atypical Hemolytic–Uremic Syndrome
Management of hypertensive disorders during pregnancy: summary of NICE guidance (Source: Nephrology Now)
Source: Nephrology Now - August 23, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Nephrology Fluid & Electrolytes Review Source Type: research
