Hemodialysis: core curriculum 2014.
Another topic nicely reviewed by the AJKD Core Curriculum. : CKD–Mineral and Bone Disorder: Core Curriculum 2011 Home Hemodialysis, Daily Hemodialysis, and Nocturnal Hemodialysis: Core Curriculum 2009 Toxic Nephropathies: Core Curriculum 2010 (Source: Nephrology Now)
Source: Nephrology Now - April 19, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: AJKD Core Curriculum Source Type: research

Clinical practice guideline on diagnosis and treatment of hyponatremia
These multispecialty guidelines provide a very practical approach to management of this very common clinical disorder. : KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease KDIGO Clinical Practice Guideline for Glomerulonephritis Calcium Kidney Stones (Source: Nephrology Now)
Source: Nephrology Now - April 19, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Practice Guidelines Fluid & Electrolytes Source Type: research

Intensive Hemodialysis Associates with Improved Pregnancy Outcomes: A Canadian and United States Cohort Comparison
This elegant cohort comparison study shows that pregnant ESRD patients in Canada have better pregnancy-related outcomes (including higher live birth rate and mean gestational age) compared to their American counterparts due to more intensive hemodialysis. : Pregnancy Outcomes in Women with Chronic Kidney Disease: A Systematic Review Hemodialysis and peritoneal dialysis are associated with similar outcomes for end-stage renal disease treatment in Canada Association between estimated glomerular filtration rate at initiation of dialysis and mortality (Source: Nephrology Now)
Source: Nephrology Now - April 19, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Hemodialysis Pregnancy and Hypertension/Renal Disease Source Type: research

Haemodialysis in patients treated with oral anticoagulant: should we heparinize?
This study shows that it is possible to dialyze anticoagulated patients without using heparin in the hemodialysis circuit. The data in the small study show no decrease in dialysis session length or increase circuit clotting scores. Furthermore, there was no benefit to a specialized grafted heparin membrane (HeprAN) as compared to the usual polysulphone variety. : Prevention of Dialysis Catheter Malfunction with Recombinant Tissue Plasminogen Activator The time course of peritoneal transport parameters in peritoneal dialysis patients who develop encapsulating peritoneal sclerosis. Effect of frequent hemodialysis on residua...
Source: Nephrology Now - April 19, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Trial Results Hemodialysis Source Type: research

Risk of End-Stage Renal Disease Following Live Kidney Donation
This study compare the risk of developing ESRD in kidney donors to that of similarly screened healthy nondonors (a cohort of NHANES III participants). The results show estimated lifetime risk of ESRD was 90 per 10 000 donors, 326 per 10 000 unscreened nondonors (general population), and 14 per 10 000 healthy nondonors. : Comparison of Risk Prediction Using the CKD-EPI Equation and the MDRD Study Equation for Estimated Glomerular Filtration Rate Perioperative Mortality and Long-term Survival Following Live Kidney Donation Acute dialysis risk in living kidney donors (Source: Nephrology Now)
Source: Nephrology Now - April 19, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Trial Results Renal Transplantation Source Type: research

2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8)
: KDIGO Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease The Impact of Timing of Maximal Crystalloid Hydration on Early Graft Function During Kidney Transplantation Guidelines for the prevention and management of Mycobacterium tuberculosis infection and disease in adult patients with chronic kidney disease. (Source: Nephrology Now)
Source: Nephrology Now - April 19, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Practice Guidelines Hypertension Source Type: research

Canadian Society of Nephrology 2014 clinical practice guideline for timing the initiation of chronic dialysis
The CSN 2014 clinical practice guideline for timing the initiation of chronic dialysis makes the following main points. Early initiation of dialysis does not improve survival, quality of life or hospital admission rates compared with late or deferred initiation of dialysis.  As a result, they  recommend an “intent-to-defer” strategy, whereby patients with an eGFR < 15 mL/ min per 1.73 m2 are closely monitored, with dialysis initiated when symptoms develop or eGFR is ≤ 6 mL/min per 1.73m2. : A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis Broadening Options for Long-term Dialysis...
Source: Nephrology Now - April 19, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Practice Guidelines Hemodialysis Source Type: research

Lipid Management in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2013 Clinical Practice Guideline
This paper summarizes 8 key recommendations in the area of lipid management based on Kidney Disease: Improving Global Outcomes (KDIGO) 2013 Clinical Practice Guideline. : Evaluation and Management of Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2012 Clinical Practice Guideline KDIGO Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease KDIGO Clinical Practice Guidelines for AKI (Source: Nephrology Now)
Source: Nephrology Now - April 19, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Practice Guidelines Source Type: research

Cardiovascular protection by β-blockade in hypertensive haemodialysis patients: the Hypertension in Haemodialysis Patients Treated With Atenolol or Lisinopril (HDPAL) trial.
This was an open-label trial of atenolol vs lisinopril administered three times per week post-dialysis in patient with hypertension and left ventricular hypertrophy. The atenolol treated group had lower cardiovascular morbidity and all-cause hospitalizations. : Bedtime Dosing of Antihypertensive Medications Reduces Cardiovascular Risk in CKD Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial. High-Efficiency Postdilution Online Hemodiafiltration Reduces All-Cause Mortality in Hemodialysis Patients (Source: Nephrology Now)
Source: Nephrology Now - April 19, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Trial Results Hemodialysis Hypertension Source Type: research

High versus Low Blood-Pressure Target in Patients with Septic Shock
This multicentre, open label trial randomized over 700 patients with septic shock to undergo resuscitation to MAP target of 80-85 mmHg or 65-70 mmHg. The primary outcome of mortality was no different in either group at 28 or 90 days. However, the higher target group required less renal replacement therapy. : Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care. Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes Intensity of Continuous Renal-Replacement Therapy in Critically Ill Patients (Source: Nephrology Now)
Source: Nephrology Now - April 19, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Clinical Nephrology Clinical Trial Results General Nephrology Source Type: research

KDIGO 2013 Clinical Practice Guideline for Lipid Management in Chronic Kidney Disease
The full KDIGO lipid guidelines are available here. : Lipid Management in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2013 Clinical Practice Guideline Evaluation and Management of Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2012 Clinical Practice Guideline KDIGO Clinical Practice Guidelines for AKI (Source: Nephrology Now)
Source: Nephrology Now - December 22, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Practice Guidelines Internal Medicine for Nephrologists Vascular Disease/Calcification Source Type: research

Lipid Management in Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2013 Clinical Practice Guideline
This synopsis of the recently published KDIGO guidelines focuses on 8 recommendations related to assessment of lipid status and treatment with a statin-based regimen in adults. : Evaluation and Management of Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2012 Clinical Practice Guideline KDIGO 2013 Clinical Practice Guideline for Lipid Management in Chronic Kidney Disease Screening and Follow-Up of Living Kidney Donors: A Systematic Review of Clinical Practice Guidelines (Source: Nephrology Now)
Source: Nephrology Now - December 22, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Internal Medicine for Nephrologists Vascular Disease/Calcification Source Type: research

Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis
The CORAL trial failed to show any benefit of renal-artery stenting when added on to medical therapy in patients with atherosclerotic renal-artery stenosis. : Stent Placement in Patients With Atherosclerotic Renal Artery Stenosis and Impaired Renal Function: A Randomized Trial. Is There Any Reason to Stent Atherosclerotic Renal Artery Stenosis? Revascularization versus Medical Therapy for Renal-Artery Stenosis (Source: Nephrology Now)
Source: Nephrology Now - December 22, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Renal Artery Stenosis Source Type: research

Treatment of severe alcoholic hepatitis with corticosteroids and pentoxifylline.
This RCT in alcoholic hepatitis showed a trend to a reduction in hepatorenal syndrome in patients treated with pentoxifylline-prednisolone compared to placebo-prednisolone group (8.4% vs 15.3%, P = .07). : Rituximab and mycophenolate mofetil for relapsing proliferative lupus nephritis: a long-term prospective study Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes Fungal Peritonitis in Peritoneal Dialysis Patients: Successful Prophylaxis with Fluconazole, as Demonstrated by Prospective Randomized Control Trial (Source: Nephrology Now)
Source: Nephrology Now - December 22, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Source Type: research

Kidney Disease in the Setting of Liver Failure: Core Curriculum 2013
This review from the AJKD Core Curriculum goes over kidney disease in the setting of liver failure. : Biomarkers in Nephrology: Core Curriculum 2013 Nutritional Considerations in Kidney Disease: Core Curriculum 2010 CKD–Mineral and Bone Disorder: Core Curriculum 2011 (Source: Nephrology Now)
Source: Nephrology Now - December 22, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: AJKD Core Curriculum General Nephrology Review Source Type: research