Effect of frequent hemodialysis on residual kidney function
This study examined the data from both the Frequent Hemodialysis Network Daily and Nocturnal Trials to determine the effects of more frequent dialysis on residual kidney function. Although limited by small number, there is clear evidence that frequent nocturnal hemodialysis was associated with more rapid loss of residual kidney function. The data is so far indeterminate for frequent daily hemodialysis.
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Effects of Six versus Three Times per Week Hemodialysis on Physical Performance, Health, and Functioning: Frequent Hemodialysis Network (FHN) Randomized Trials.
ASN 2010 Late Breaking Clinical Trial Results | SHARP, Pre...
Source: Nephrology Now - July 14, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Nephrology Clinical Trial Results Hemodialysis Residual Renal Function Source Type: research
Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage
This randomized controlled trial compared two strategies of blood pressure management after spontaneous intracerebral hemorrhage. Patients were randomized intensive blood treatment to target a systolic BP of (Source: Nephrology Now)
Source: Nephrology Now - July 14, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Hypertension Internal Medicine for Nephrologists Source Type: research
Evaluation and Management of Chronic Kidney Disease: Synopsis of the Kidney Disease: Improving Global Outcomes 2012 Clinical Practice Guideline
This synopsis of the 2012 KDIGO CKD clinical practice guidelines focuses on 10 key recommendations (out of the 110 recommendations found in the full guideline) related to definition, classification, monitoring, and management of CKD in adults.
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KDIGO Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease
Clinical Practice Guidelines For Peritoneal Access – NOW FREE FULL TEXT
Treatment Guidelines for Dialysis Catheter–Related Bacteremia: An Update (Source: Nephrology Now)
Source: Nephrology Now - July 14, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Practice Guidelines Source Type: research
Biomarkers in Nephrology: Core Curriculum 2013
This article of the AJKD Core Curriculum, reviews biomarkers of kidney disease in the settings of acute kidney injury, chronic kidney disease,nephrotoxin exposure and glomerulonephritis.
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CKD–Mineral and Bone Disorder: Core Curriculum 2011
Genetic Investigations of Kidney Disease
Nutritional Considerations in Kidney Disease: Core Curriculum 2010 (Source: Nephrology Now)
Source: Nephrology Now - April 1, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury AJKD Core Curriculum Chronic Kidney Disease Glomerulonephritis Source Type: research
Genetic Investigations of Kidney Disease
This article from the AJKD Core Curriculum reviews well-established and novel methods used in the investigation of genetic causes of kidney diseases.
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Biomarkers in Nephrology: Core Curriculum 2013
Nutritional Considerations in Kidney Disease: Core Curriculum 2010
Kidney Development: Core Curriculum 2011 (Source: Nephrology Now)
Source: Nephrology Now - April 1, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: General Nephrology Source Type: research
Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis.
Recently, 7 trials investigating the role of hydroxyethyl starch in the critically ill were retracted because of scientific misconduct.
This meta-analysis, which excludes these studies, indicates an increased risk of death and acute kidney injury in critically ill patients requiring acute volume resuscitation.
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Adverse Effects Associated With Transcatheter Aortic Valve Implantation: A Meta-analysis of Contemporary Studies.
Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care.
Chronic Dialysis and Death Among Survivors of Acute Kidney Injury Requiring Dialysis (Source: Nephrology Now)
Source: Nephrology Now - April 1, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Critical Care Source Type: research
Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
This study does not clarify whether this relationship is causal.
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Chronic Dialysis and Death Among Survivors of Acute Kidney Injury Requiring Dialysis
High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysis.
The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysis (Source: Nephrology Now)
Source: Nephrology Now - April 1, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Source Type: research
MyStudies.org
This site provides concise summaries on landmark papers published in clinical medicine, including Nephrology.
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Staphylococcus aureus Infections in Hemodialysis: What a Nephrologist Should Know
A Randomized, Controlled Trial of Early versus Late Initiation of Dialysis
Update in Nephrology: Evidence Published in 2010 (Source: Nephrology Now)
Source: Nephrology Now - April 1, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Educational Resource Source Type: research
Rituximab is an efficient and safe treatment in adults with steroid-dependent minimal change disease.
This small retrospective study analyzed the efficacy and safety of rituximab in adults with steroid-dependent minimal change disease. Of the seventeen relapsing steroid-dependent patients treated with rituximab, eleven had no relapses with nine being able to come off all other drugs during the mean 29.5 month follow-up period. This sets the stage for a prospective randomized controlled trial.
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A Randomized Trial to Assess the Impact of Early Steroid Withdrawal on Growth in Pediatric Renal Transplantation: The TWIST Study
Rituximab and mycophenolate mofetil for relapsing proliferative lupus nephritis: a long-term prospec...
Source: Nephrology Now - April 1, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Nephrology Glomerulonephritis Source Type: research
Expert guidelines for the management of alport syndrome and thin basement membrane nephropathy.
This review article provides an expert look at the diagnosis and management of alport syndrome and thin basement membrane nephropathy.
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Focal Segmental Glomerulosclerosis
Atypical Hemolytic–Uremic Syndrome
Dementia and cognitive impairment in ESRD: diagnostic and therapeutic strategies (Source: Nephrology Now)
Source: Nephrology Now - April 1, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Nephrology Clinical Practice Guidelines Glomerulonephritis Source Type: research
Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study
This study using insurance claims of over 26 000 woman compared to randomly selected controls to assess the risk of chronic kidney disease and end-stage kidney disease in patients with hypertension during pregnancy. The results showed that they had a greater risk of CKD and ESRD with adjusted HRs of with adjusted HRs of 9.38 (95% CI 7.09-12.4) and 12.4 (95% CI 8.54-18.0), respectively. Furthermore, women with preeclampsia/eclampsia were at the highest risk.
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Pregnancy Outcomes in Women with Chronic Kidney Disease: A Systematic Review
Persistent Asymptomatic Isolated Microscopic Hematuria in Israeli Adolescents and You...
Source: Nephrology Now - April 1, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Nephrology Pregnancy and Hypertension/Renal Disease Source Type: research
High-Efficiency Postdilution Online Hemodiafiltration Reduces All-Cause Mortality in Hemodialysis Patients
This multicenter, open-label, randomized controlled trial randomized chronic hemodialysis patients to conventional hemodialysis or high-efficiency postdilution online hemodiafiltration (OL-HDF).
Patients assigned to OL-HDF had a 30% lower risk of all-cause mortality compared to those on conventional hemodialysis (hazard ratio [HR], 0.70; 95% confidence interval [95% CI], 0.53–0.92; P=0.01). In addition, the OL-HDF group had a 33% lower risk of cardiovascular mortality (HR, 0.67; 95% CI, 0.44–1.02; P=0.06) and a 55% lower risk of infection-related mortality (HR, 0.45; 95% CI, 0.21–0.96; P=0.03).
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Cardio...
Source: Nephrology Now - February 16, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Hemodialysis Source Type: research
Enoxaparin Outcomes in Patients With Moderate Renal Impairment
This review of enoxaparin compared the bleeding events rates in patients with moderate renal impairment (CrCl of 30-50 ml/min) to those patients with normal renal function (CrCl > 80 ml/min). Enoxaparin was dosed at 1 mg/kg bid or 1.5 mg/kg OD. The primary outcome of major bleeding occurred in 22.0% of the renal impairment group vs 5.7% of the normal renal function group. There was no evidence of recurrent thromboembolism in either group. Given the frequency of enoxaparin use, this study highlights the need for further investigation regarding the appropriate dosing in patients with moderate renal impairment.
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Updated...
Source: Nephrology Now - January 28, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Trial Results Source Type: research
Adverse Effects Associated With Transcatheter Aortic Valve Implantation: A Meta-analysis of Contemporary Studies.
This meta-analysis identifies acute kidney injury requiring dialysis as a common complication of transcatheter aortic valve implantation, occurring in approximately 5% of patients.
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Chronic Dialysis and Death Among Survivors of Acute Kidney Injury Requiring Dialysis
The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysis
High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysis. (Source: Nephrology Now)
Source: Nephrology Now - January 28, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Source Type: research
Peginesatide in Patients with Anemia Undergoing Hemodialysis
Peginesatide, a synthetic peptide-based erythropoiesis-stimulating agent (ESA), administered monthly, was as effective as epoetin, administered 1 to 3 times per week, in maintaining hemoglobin levels in patients undergoing hemodialysis.
See the accompanying article on outcomes in CKD patients: http://www.nejm.org/doi/full/10.1056/NEJMoa1203166
See the accompanying editorial: http://www.nejm.org/doi/full/10.1056/NEJMe1215043
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Prevention of Dialysis Catheter Malfunction with Recombinant Tissue Plasminogen Activator
“Daily” Dialysis — Lessons from a Randomized, Controlled Trial
Testosterone deficiency is a cause of an...
Source: Nephrology Now - January 28, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Anemia Hemodialysis Source Type: research
