An approach to cystic kidney diseases: the clinician ’ s view
This is a nice review on the clinical classification of cystic kidney diseases while new techniques are, including next-generation sequencing, are still under investigation.
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Genetic Investigations of Kidney Disease
The Native Kidney Biopsy: Update and Evidence for Best Practice.
Perioperative acute kidney injury: risk factors, recognition, management, and outcomes (Source: Nephrology Now)
Source: Nephrology Now - December 17, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Nephrology General Nephrology Source Type: research
An approach to cystic kidney diseases: the clinician’s view
This is a nice review on the clinical classification of cystic kidney diseases while new techniques are, including next-generation sequencing, are still under investigation.
:
Genetic Investigations of Kidney Disease
Perioperative acute kidney injury: risk factors, recognition, management, and outcomes
Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies (Source: Nephrology Now)
Source: Nephrology Now - December 17, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Nephrology General Nephrology Source Type: research
Survival advantage of lanthanum carbonate for hemodialysis patients with uncontrolled hyperphosphatemia
This retrospective study of maintenance hemodialysis patients showed that treatment with lanthanum was independently associated with a reduction in all cause mortality in those patients with uncontrolled hyperphosphatemia.
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Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trial.
Survival in daily home hemodialysis and matched thrice-weekly in-center hemodialysis patients.
Chronic kidney disease and dipstick proteinuria are risk factors for stent thrombosis in patients with myocardial infarction (Source: Nephrology Now)
Source: Nephrology Now - December 17, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Trial Results Fluid & Electrolytes General Nephrology Hemodialysis Source Type: research
The Impact of Timing of Dialysis Initiation on Mortality in Patients with Peritoneal Dialysis
A Korean cohort of 495 incident PD patients were analyzed with respect to the impact of timing of dialysis initiation on mortality. The authors found that an eGFR < 5 mL/min/1.73m(2) at the initiation of PD was a significant risk factor for death, while an eGFR >10 mL/min/1.73m(2) at the initiation of PD was not associated with improved survival compared with an eGFR of 5 – 10 mL/min/1.73m(2) at the initiation of PD.
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Similar Outcomes With Hemodialysis and Peritoneal Dialysis in Patients With End-Stage Renal Disease
Canadian Society of Nephrology 2014 clinical practice guideline for timing the initiation of...
Source: Nephrology Now - December 17, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease General Nephrology Peritoneal Dialysis Source Type: research
Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes
In this 6-year follow-up study of patients enrolled in ADVANCE, there was no evidence that intensive glucose control during the trial led to long-term benefits with respect to mortality or macrovascular events. Though event rates were small, there was a reduction in end-stage renal disease in those patients in the intensive glucose arm, hazard ratio 0.54; 95% CI, 0.34 to 0.85; P=0.007.
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Intensive Diabetes Therapy and Glomerular Filtration Rate in Type 1 Diabetes
Long-term Renal Outcomes of Patients With Type 1 Diabetes Mellitus and Microalbuminuria
Renal outcomes with different fixed-dose combination therapies in patien...
Source: Nephrology Now - November 17, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Diabetes Source Type: research
Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis
In this RCT, patients with ANCA-associated vasculitis who achieved complete remission after a cyclophosphamide-glucocorticoid regimen were randomly assigned to receive intermittent rituximab (days 0 and 14 and at months 6, 12, and 18) or daily azathioprine until month 22. Major relapse was less common in the rituximab arm than the azathioprine arm (5% vs 29%) with a hazard ratio for relapse of 6.61; 95% confidence interval, 1.56 to 27.96; P=0.002). There were no differences in adverse events between arms.
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Efficacy of Remission-Induction Regimens for ANCA-Associated Vasculitis
Cardiorenal End Points in a Trial of Ali...
Source: Nephrology Now - November 17, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Vasculitis Source Type: research
Integration of Acid –Base and Electrolyte Disorders
This review, appropriate for trainees and practicing physicians, provides an approach to the diagnosis of acid-base disorders.
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Electrolyte and Acid–Base Disturbances in Patients with Diabetes Mellitus
Policy Statement of Canadian Society of Transplantation and Canadian Society of Nephrology on Organ Trafficking and Transplant Tourism
KDIGO Clinical Practice Guideline for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder (CKD–MBD) (Source: Nephrology Now)
Source: Nephrology Now - November 17, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Fluid & Electrolytes Source Type: research
Integration of Acid–Base and Electrolyte Disorders
This review, appropriate for trainees and practicing physicians, provides an approach to the diagnosis of acid-base disorders.
:
Policy Statement of Canadian Society of Transplantation and Canadian Society of Nephrology on Organ Trafficking and Transplant Tourism
KDIGO Clinical Practice Guideline for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder (CKD–MBD)
Podocyte disorders: core curriculum 2011 (Source: Nephrology Now)
Source: Nephrology Now - November 17, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Fluid & Electrolytes Source Type: research
Gestational Hypertension and Preeclampsia in Living Kidney Donors
This retrospective cohort study showed an increased risk of gestational hypertension or preeclampsia in women who have been living kidney donors, 11% in donors vs 5% in non-donors (OR 2.4; 95% CI, 1.2 to 5.0; P=0.01).
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Acute dialysis risk in living kidney donors
Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study
Perioperative Mortality and Long-term Survival Following Live Kidney Donation (Source: Nephrology Now)
Source: Nephrology Now - November 17, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Pregnancy and Hypertension/Renal Disease Renal Transplantation Source Type: research
Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease
In patients with early PKD, dual blockage of the RAS system provided no advantage over ACE inhibitor alone. Patients targeted to the standard blood pressure target (120/70 to 130/80 mm Hg) vs a low blood-pressure target (95/60 to 110/75 mm Hg) had reduced annual % increase in total kidney volume (6.6% vs. 5.6%, P=0.006) and more reduction in urinary albumin excretion (3.77% vs 2.43% , P<0.001). However, there was no difference in rate of change in estimated GFR.
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Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease
Effect of longer term modest salt reduction on blood pressure: Cochrane syst...
Source: Nephrology Now - November 17, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Polycystic Kidney Disease Source Type: research
Successful Delivery of RRT in Ebola Virus Disease
This timely article describes the protocol used at Emory University Hospital to provide dialysis in a patient with Ebola virus and proposes clinical practice guidelines for acute dialysis in this infection.
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KDIGO Clinical Practice Guidelines for AKI
KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease
Stage IV Chronic Kidney Disease (Source: Nephrology Now)
Source: Nephrology Now - November 16, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Clinical Nephrology Critical Care Source Type: research
Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury
In this sub-study of the POISE-2 study, neither ASA or clonidine reduced the risk of acute kidney injury after non-cardiac surgery.
Of note, aspirin increased the risk of major bleeding (which was associated with a greater risk of acute kidney injury). As well, clonidine increased the risk of clinically important hypotension (which was associated with a greater risk of acute kidney injury).
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Stroke and Bleeding in Atrial Fibrillation with Chronic Kidney Disease
Risk of acute kidney injury associated with the use of fluoroquinolones
Chronic Dialysis and Death Among Survivors of Acute Kidney Injury Requiring Dialysis (So...
Source: Nephrology Now - November 16, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Source Type: research
Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans
This observational study identified that among African Americans, sickle cell trait was associated with an increased risk of chronic kidney disease and albuminuria, compared with noncarriers.
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Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study
Intensive Blood-Pressure Control in Hypertensive Chronic Kidney Disease
Contraindicated Medication Use in Dialysis Patients Undergoing Percutaneous Coronary Intervention (Source: Nephrology Now)
Source: Nephrology Now - November 16, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Source Type: research
A Controlled Trial of Renal Denervation for Resistant Hypertension
The SYMPLICITY HTN-3 trial did not show a significant reduction of systolic blood pressure in patients with resistant hypertension 6 months after renal-artery denervation as compared with a sham control.
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Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial
Intensive Blood-Pressure Control in Hypertensive Chronic Kidney Disease
Treatment blood pressure targets for hypertension. (Source: Nephrology Now)
Source: Nephrology Now - April 20, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Clinical Trial Results Hypertension Source Type: research
Non-selective β Blockers Increase Risk for Hepatorenal Syndrome and Death in Patients with Cirrhosis and Spontaneous Bacterial Peritonitis
This interesting study of non-selective beta blockers in patients with cirrhosis and spontaneous bacterial peritonitis shows that their use increases the risk of acute kidney injury and hepatorenal syndrome in this population. The authors advise against their use in these patients. Furthermore, they worsen hemodynamic instability as well as increase length of hospitalization.
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Chronic Dialysis and Death Among Survivors of Acute Kidney Injury Requiring Dialysis
Risk of acute kidney injury associated with the use of fluoroquinolones
The effect of combination treatment with aliskiren and blockers of the renin-angiotensin sy...
Source: Nephrology Now - April 19, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Source Type: research
