Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease

In patients with early PKD, dual blockage of the RAS system provided no advantage over ACE inhibitor alone.  Patients targeted to the standard blood pressure target (120/70 to 130/80 mm Hg) vs a low blood-pressure target (95/60 to 110/75 mm Hg) had reduced annual % increase in total kidney volume (6.6% vs. 5.6%, P=0.006) and more reduction in urinary albumin excretion (3.77% vs 2.43% , P<0.001).  However, there was no difference in rate of change in estimated GFR. : Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials Systematic Review: Blood Pressure Target in Chronic Kidney Disease and Proteinuria as an Effect Modifier
Source: Nephrology Now - Category: Urology & Nephrology Authors: Tags: Chronic Kidney Disease Polycystic Kidney Disease Source Type: research