Comparison of low-dose intravenous cyclophosphamide with oral mycophenolate mofetil in the treatment of lupus nephritis

This study randomized patients with LN (class III, IV, or V) to receive induction with low-dose CYC or oral MMF with the exclusion of patients with crescentic LN, a serum creatinine over 265 μmol/l, and neurological or pulmonary lupus were excluded. Maintenance therapy with azathioprine and low-dose corticosteroid was started at end of induction therapy. The complete remission rate was 50% in CYC and 54% in MMF group, adverse effect profile was similar except for more gastrointestinal symptoms in the  MMF group. : Mycophenolate versus Azathioprine as Maintenance Therapy for Lupus Nephritis Efficacy of Remission-Induction Regimens for ANCA-Associated Vasculitis Prolonged disease-free remission following rituximab and low-dose cyclophosphamide therapy for renal ANCA-associated vasculitis
Source: Nephrology Now - Category: Urology & Nephrology Authors: Tags: Acute Kidney Injury General Nephrology Glomerulonephritis Source Type: research