Jury out on liquid biopsies for cancer
Nature Biotechnology 36, 209 (2018).
doi:10.1038/nbt0318-209a
Author: Mark Ratner (Source: Nature Biotechnology)
Source: Nature Biotechnology - March 6, 2018 Category: Biotechnology Authors: Mark Ratner Tags: News Source Type: research
EPO revokes Broad's CRISPR patent
Nature Biotechnology 36, 209 (2018).
doi:10.1038/nbt0318-209b
Author: Charlotte Harrison (Source: Nature Biotechnology)
Source: Nature Biotechnology - March 6, 2018 Category: Biotechnology Authors: Charlotte Harrison Tags: News Source Type: research
Migraine drug race turns its final corner, FDA decisions in sight
Nature Biotechnology 36, 207 (2018).
doi:10.1038/nbt0318-207
Author: Elie Dolgin (Source: Nature Biotechnology)
Source: Nature Biotechnology - March 6, 2018 Category: Biotechnology Authors: Elie Dolgin Tags: News Source Type: research
Amazon's cloud on the healthcare horizon
Nature Biotechnology 36, 205 (2018).
doi:10.1038/nbt.4107
A new venture from Amazon, JP Morgans and Berkshire Hathaway has US healthcare in its crosshairs. It may also offer opportunities for innovators in health IT and digital medicine. (Source: Nature Biotechnology)
Source: Nature Biotechnology - March 6, 2018 Category: Biotechnology Tags: Editorial Source Type: research
IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor
Nature Biotechnology 36, 346 (2018).
doi:10.1038/nbt.4086
Authors: Keishi Adachi, Yosuke Kano, Tomohiko Nagai, Namiko Okuyama, Yukimi Sakoda & Koji Tamada
Infiltration, accumulation, and survival of chimeric antigen receptor T (CAR-T) cells in solid tumors is crucial for tumor clearance. We engineered CAR-T cells to express interleukin (IL)-7 and CCL19 (7 × 19 CAR-T cells), as these factors are essential for the maintenance of T-cell zones in lymphoid organs. In mice, 7 × 19 CAR-T cells achieved complete regression of pre-established solid tumors and prolonged mouse survival, with superior anti-tumor ...
Source: Nature Biotechnology - March 5, 2018 Category: Biotechnology Authors: Keishi Adachi Yosuke Kano Tomohiko Nagai Namiko Okuyama Yukimi Sakoda Koji Tamada Tags: Research Source Type: research
Recon3D enables a three-dimensional view of gene variation in human metabolism
Nature Biotechnology 36, 272 (2018).
doi:10.1038/nbt.4072
Authors: Elizabeth Brunk, Swagatika Sahoo, Daniel C Zielinski, Ali Altunkaya, Andreas Dräger, Nathan Mih, Francesco Gatto, Avlant Nilsson, German Andres Preciat Gonzalez, Maike Kathrin Aurich, Andreas Prlić, Anand Sastry, Anna D Danielsdottir, Almut Heinken, Alberto Noronha, Peter W Rose, Stephen K Burley, Ronan M T Fleming, Jens Nielsen, Ines Thiele & Bernhard O Palsson (Source: Nature Biotechnology)
Source: Nature Biotechnology - February 19, 2018 Category: Biotechnology Authors: Elizabeth Brunk Swagatika Sahoo Daniel C Zielinski Ali Altunkaya Andreas Dr ä ger Nathan Mih Francesco Gatto Avlant Nilsson German Andres Preciat Gonzalez Maike Kathrin Aurich Andreas Prli ć Anand Sastry Anna D Danielsdottir Almut Heinken Alberto Noronh Tags: Research Source Type: research
Random access in large-scale DNA data storage
Nature Biotechnology 36, 242 (2018).
doi:10.1038/nbt.4079
Authors: Lee Organick, Siena Dumas Ang, Yuan-Jyue Chen, Randolph Lopez, Sergey Yekhanin, Konstantin Makarychev, Miklos Z Racz, Govinda Kamath, Parikshit Gopalan, Bichlien Nguyen, Christopher N Takahashi, Sharon Newman, Hsing-Yeh Parker, Cyrus Rashtchian, Kendall Stewart, Gagan Gupta, Robert Carlson, John Mulligan, Douglas Carmean, Georg Seelig, Luis Ceze & Karin Strauss (Source: Nature Biotechnology)
Source: Nature Biotechnology - February 19, 2018 Category: Biotechnology Authors: Lee Organick Siena Dumas Ang Yuan-Jyue Chen Randolph Lopez Sergey Yekhanin Konstantin Makarychev Miklos Z Racz Govinda Kamath Parikshit Gopalan Bichlien Nguyen Christopher N Takahashi Sharon Newman Hsing-Yeh Parker Cyrus Rashtchian Kendall Stewart Gagan G Tags: Research Source Type: research
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo
Nature Biotechnology 36, 258 (2018).
doi:10.1038/nbt.4071
Authors: Suping Li, Qiao Jiang, Shaoli Liu, Yinlong Zhang, Yanhua Tian, Chen Song, Jing Wang, Yiguo Zou, Gregory J Anderson, Jing-Yan Han, Yung Chang, Yan Liu, Chen Zhang, Liang Chen, Guangbiao Zhou, Guangjun Nie, Hao Yan, Baoquan Ding & Yuliang Zhao
Nanoscale robots have potential as intelligent drug delivery systems that respond to molecular triggers. Using DNA origami we constructed an autonomous DNA robot programmed to transport payloads and present them specifically in tumors. Our nanorobot is functionalized on the outside with a DNA aptamer that bi...
Source: Nature Biotechnology - February 12, 2018 Category: Biotechnology Authors: Suping Li Qiao Jiang Shaoli Liu Yinlong Zhang Yanhua Tian Chen Song Jing Wang Yiguo Zou Gregory J Anderson Jing-Yan Han Yung Chang Yan Liu Chen Zhang Liang Chen Guangbiao Zhou Guangjun Nie Hao Yan Baoquan Ding Yuliang Zhao Tags: Research Source Type: research
Sugar release and growth of biofuel crops are improved by downregulation of pectin biosynthesis
Nature Biotechnology 36, 249 (2018).
doi:10.1038/nbt.4067
Authors: Ajaya K Biswal, Melani A Atmodjo, Mi Li, Holly L Baxter, Chang Geun Yoo, Yunqiao Pu, Yi-Ching Lee, Mitra Mazarei, Ian M Black, Ji-Yi Zhang, Hema Ramanna, Adam L Bray, Zachary R King, Peter R LaFayette, Sivakumar Pattathil, Bryon S Donohoe, Sushree S Mohanty, David Ryno, Kelsey Yee, Olivia A Thompson, Miguel Rodriguez, Alexandru Dumitrache, Jace Natzke, Kim Winkeler, Cassandra Collins, Xiaohan Yang, Li Tan, Robert W Sykes, Erica L Gjersing, Angela Ziebell, Geoffrey B Turner, Stephen R Decker, Michael G Hahn, Brian H Davison, Michael K Udvardi, Jonath...
Source: Nature Biotechnology - February 12, 2018 Category: Biotechnology Authors: Ajaya K Biswal Melani A Atmodjo Mi Li Holly L Baxter Chang Geun Yoo Yunqiao Pu Yi-Ching Lee Mitra Mazarei Ian M Black Ji-Yi Zhang Hema Ramanna Adam L Bray Zachary R King Peter R LaFayette Sivakumar Pattathil Bryon S Donohoe Sushree S Mohanty David Ryno Ke Tags: Research Source Type: research
People
Nature Biotechnology 36, 204 (2018).
doi:10.1038/nbt.4082 (Source: Nature Biotechnology)
Source: Nature Biotechnology - February 6, 2018 Category: Biotechnology Tags: Careers and Recruitment Source Type: research
Erratum: Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
Nature Biotechnology 36, 196 (2018).
doi:10.1038/nbt0218-196d
Authors: Trung Van Chu, Timm Weber, Benedikt Wefers, Wolfgang Wurst, Sandrine Sander, Klaus Rajewsky & Ralf Kühn (Source: Nature Biotechnology)
Source: Nature Biotechnology - February 6, 2018 Category: Biotechnology Authors: Trung Van Chu Timm Weber Benedikt Wefers Wolfgang Wurst Sandrine Sander Klaus Rajewsky Ralf K ü hn Tags: Research Source Type: research
Corrigendum: Reproducing with DNA
Nature Biotechnology 36, 196 (2018).
doi:10.1038/nbt0218-196c
Author: Malorye Allison Branca (Source: Nature Biotechnology)
Source: Nature Biotechnology - February 6, 2018 Category: Biotechnology Authors: Malorye Allison Branca Tags: Research Source Type: research
Corrigendum: Assisted reproductive technologies to prevent human mitochondrial disease transmission
Nature Biotechnology 36, 196 (2018).
doi:10.1038/nbt0218-196b
Authors: Andy Greenfield, Peter Braude, Frances Flinter, Robin Lovell-Badge, Caroline Ogilvie & Anthony C F Perry (Source: Nature Biotechnology)
Source: Nature Biotechnology - February 6, 2018 Category: Biotechnology Authors: Andy Greenfield Peter Braude Frances Flinter Robin Lovell-Badge Caroline Ogilvie Anthony C F Perry Tags: Research Source Type: research
Corrigendum: Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea
Nature Biotechnology 36, 196 (2018).
doi:10.1038/nbt0218-196a
Authors: Robert M Bowers, Nikos C Kyrpides, Ramunas Stepanauskas, Miranda Harmon-Smith, Devin Doud, T B K Reddy, Frederik Schulz, Jessica Jarett, Adam R Rivers, Emiley A Eloe-Fadrosh, Susannah G Tringe, Natalia N Ivanova, Alex Copeland, Alicia Clum, Eric D Becraft, Rex R Malmstrom, Bruce Birren, Mircea Podar, Peer Bork, George M Weinstock, George M Garrity, Jeremy A Dodsworth, Shibu Yooseph, Granger Sutton, Frank O Glöckner, Jack A Gilbert, William C Nelson, Steven J Hallam, Sean P Jungbluth, Thijs J G Ettema, Scott Tighe, Konstantinos T Konstantini...
Source: Nature Biotechnology - February 6, 2018 Category: Biotechnology Authors: Robert M Bowers Nikos C Kyrpides Ramunas Stepanauskas Miranda Harmon-Smith Devin Doud T B K Reddy Frederik Schulz Jessica Jarett Adam R Rivers Emiley A Eloe-Fadrosh Susannah G Tringe Natalia N Ivanova Alex Copeland Alicia Clum Eric D Becraft Rex R Malmstr Tags: Research Source Type: research
Putting a number on neoepitope quality
Nature Biotechnology 36, 151 (2018).
doi:10.1038/nbt.4074
Author: Irene Jarchum (Source: Nature Biotechnology)
Source: Nature Biotechnology - February 6, 2018 Category: Biotechnology Authors: Irene Jarchum Tags: News and Views Source Type: research
