Drugmakers cling to dual IL-13/IL-4 blockbuster hopes
Nature Biotechnology 36, 3 (2018).
doi:10.1038/nbt0118-3
Author: Cormac Sheridan (Source: Nature Biotechnology)
Source: Nature Biotechnology - January 10, 2018 Category: Biotechnology Authors: Cormac Sheridan Tags: News Source Type: research
Functional interrogation and mining of natively paired human VH:VL antibody repertoires
Nature Biotechnology 36, 152 (2018).
doi:10.1038/nbt.4052
Authors: Bo Wang, Brandon J DeKosky, Morgan R Timm, Jiwon Lee, Erica Normandin, John Misasi, Rui Kong, Jonathan R McDaniel, George Delidakis, Kendra E Leigh, Thomas Niezold, Chang W Choi, Elise G Viox, Ahmed Fahad, Alberto Cagigi, Aurélie Ploquin, Kwanyee Leung, Eun Sung Yang, Wing-Pui Kong, William N Voss, Aaron G Schmidt, M Anthony Moody, David R Ambrozak, Amy R Henry, Farida Laboune, Julie E Ledgerwood, Barney S Graham, Mark Connors, Daniel C Douek, Nancy J Sullivan, Andrew D Ellington, John R Mascola & George Georgiou (Source: Nature Biotechnology)
Source: Nature Biotechnology - January 8, 2018 Category: Biotechnology Authors: Bo Wang Brandon J DeKosky Morgan R Timm Jiwon Lee Erica Normandin John Misasi Rui Kong Jonathan R McDaniel George Delidakis Kendra E Leigh Thomas Niezold Chang W Choi Elise G Viox Ahmed Fahad Alberto Cagigi Aur é lie Ploquin Kwanyee Leung Eun Sung Yang W Tags: Research Source Type: research
Retrieval of a million high-quality, full-length microbial 16S and 18S rRNA gene sequences without primer bias
Nature Biotechnology 36, 190 (2018).
doi:10.1038/nbt.4045
Authors: Søren M Karst, Morten S Dueholm, Simon J McIlroy, Rasmus H Kirkegaard, Per H Nielsen & Mads Albertsen
Small subunit ribosomal RNA (SSU rRNA) genes, 16S in bacteria and 18S in eukaryotes, have been the standard phylogenetic markers used to characterize microbial diversity and evolution for decades. However, the reference databases of full-length SSU rRNA gene sequences are skewed to well-studied ecosystems and subject to primer bias and chimerism, which results in an incomplete view of the diversity present in a sample. We combine poly(A)-ta...
Source: Nature Biotechnology - January 1, 2018 Category: Biotechnology Authors: S ø ren M Karst Morten S Dueholm Simon J McIlroy Rasmus H Kirkegaard Per H Nielsen Mads Albertsen Tags: Research Source Type: research
Orthologous CRISPR – Cas9 enzymes for combinatorial genetic screens
Nature Biotechnology 36, 179 (2018).
doi:10.1038/nbt.4048
Authors: Fadi J Najm, Christine Strand, Katherine F Donovan, Mudra Hegde, Kendall R Sanson, Emma W Vaimberg, Meagan E Sullender, Ella Hartenian, Zohra Kalani, Nicolo Fusi, Jennifer Listgarten, Scott T Younger, Bradley E Bernstein, David E Root & John G Doench (Source: Nature Biotechnology)
Source: Nature Biotechnology - December 18, 2017 Category: Biotechnology Authors: Fadi J Najm Christine Strand Katherine F Donovan Mudra Hegde Kendall R Sanson Emma W Vaimberg Meagan E Sullender Ella Hartenian Zohra Kalani Nicolo Fusi Jennifer Listgarten Scott T Younger Bradley E Bernstein David E Root John G Doench Tags: Research Source Type: research
Labeling and identifying cell-specific proteomes in the mouse brain
Nature Biotechnology 36, 156 (2018).
doi:10.1038/nbt.4056
Authors: Toke P Krogager, Russell J Ernst, Thomas S Elliott, Laura Calo, Václav Beránek, Ernesto Ciabatti, Maria Grazia Spillantini, Marco Tripodi, Michael H Hastings & Jason W Chin (Source: Nature Biotechnology)
Source: Nature Biotechnology - December 18, 2017 Category: Biotechnology Authors: Toke P Krogager Russell J Ernst Thomas S Elliott Laura Calo V á clav Ber á nek Ernesto Ciabatti Maria Grazia Spillantini Marco Tripodi Michael H Hastings Jason W Chin Tags: Research Source Type: research
Mentoring for diversity in technology
Nature Biotechnology 36, 113 (2018).
doi:10.1038/nbt.4025
Author: Maggie Werner-Washburne
Psychosocial mentoring for both students and managers can help people from different backgrounds develop into a team and a community. (Source: Nature Biotechnology)
Source: Nature Biotechnology - December 18, 2017 Category: Biotechnology Authors: Maggie Werner-Washburne Tags: Careers and Recruitment Source Type: research
Virus stamping for targeted single-cell infection in vitro and in vivo
Nature Biotechnology 36, 81 (2018).
doi:10.1038/nbt.4034
Authors: Rajib Schubert, Stuart Trenholm, Kamill Balint, Georg Kosche, Cameron S Cowan, Manuel A Mohr, Martin Munz, David Martinez-Martin, Gotthold Fläschner, Richard Newton, Jacek Krol, Brigitte Gross Scherf, Keisuke Yonehara, Adrian Wertz, Aaron Ponti, Alexander Ghanem, Daniel Hillier, Karl-Klaus Conzelmann, Daniel J Müller & Botond Roska (Source: Nature Biotechnology)
Source: Nature Biotechnology - December 18, 2017 Category: Biotechnology Authors: Rajib Schubert Stuart Trenholm Kamill Balint Georg Kosche Cameron S Cowan Manuel A Mohr Martin Munz David Martinez-Martin Gotthold Fl ä schner Richard Newton Jacek Krol Brigitte Gross Scherf Keisuke Yonehara Adrian Wertz Aaron Ponti Alexander Ghanem Dani Tags: Research Source Type: research
Viruses leave their stamp on single cells
Nature Biotechnology 36, 42 (2018).
doi:10.1038/nbt.4043
Authors: Ede A Rancz & Andreas T Schaefer
A method for 'stamping' viruses achieves efficient transduction of single target cells in cultured tissues and in the mouse brain. (Source: Nature Biotechnology)
Source: Nature Biotechnology - December 18, 2017 Category: Biotechnology Authors: Ede A Rancz Andreas T Schaefer Tags: News and Views Source Type: research
Biotech's pale shadow
Nature Biotechnology 36, 20 (2018).
doi:10.1038/nbt.4046
Author: Brady Huggett
Two years after the biotech industry was called out on gender imbalance, the lack of racial diversity in the workforce is largely being ignored. (Source: Nature Biotechnology)
Source: Nature Biotechnology - December 18, 2017 Category: Biotechnology Authors: Brady Huggett Tags: Feature Source Type: research
Aligning stars of all colors
Nature Biotechnology 36, 1 (2018).
doi:10.1038/nbt.4050
The biotech industry needs to do more to recruit people from diverse groups. (Source: Nature Biotechnology)
Source: Nature Biotechnology - December 18, 2017 Category: Biotechnology Tags: Editorial Source Type: research
Multiplexed droplet single-cell RNA-sequencing using natural genetic variation
Nature Biotechnology 36, 89 (2018).
doi:10.1038/nbt.4042
Authors: Hyun Min Kang, Meena Subramaniam, Sasha Targ, Michelle Nguyen, Lenka Maliskova, Elizabeth McCarthy, Eunice Wan, Simon Wong, Lauren Byrnes, Cristina M Lanata, Rachel E Gate, Sara Mostafavi, Alexander Marson, Noah Zaitlen, Lindsey A Criswell & Chun Jimmie Ye (Source: Nature Biotechnology)
Source: Nature Biotechnology - December 11, 2017 Category: Biotechnology Authors: Hyun Min Kang Meena Subramaniam Sasha Targ Michelle Nguyen Lenka Maliskova Elizabeth McCarthy Eunice Wan Simon Wong Lauren Byrnes Cristina M Lanata Rachel E Gate Sara Mostafavi Alexander Marson Noah Zaitlen Lindsey A Criswell Chun Jimmie Ye Tags: Research Source Type: research
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain
Nature Biotechnology 36, 70 (2018).
doi:10.1038/nbt.4038
Authors: Blue B Lake, Song Chen, Brandon C Sos, Jean Fan, Gwendolyn E Kaeser, Yun C Yung, Thu E Duong, Derek Gao, Jerold Chun, Peter V Kharchenko & Kun Zhang (Source: Nature Biotechnology)
Source: Nature Biotechnology - December 11, 2017 Category: Biotechnology Authors: Blue B Lake Song Chen Brandon C Sos Jean Fan Gwendolyn E Kaeser Yun C Yung Thu E Duong Derek Gao Jerold Chun Peter V Kharchenko Kun Zhang Tags: Research Source Type: research
Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation
Nature Biotechnology 36, 61 (2018).
doi:10.1038/nbt.4037
Authors: John Beaulaurier, Shijia Zhu, Gintaras Deikus, Ilaria Mogno, Xue-Song Zhang, Austin Davis-Richardson, Ronald Canepa, Eric W Triplett, Jeremiah J Faith, Robert Sebra, Eric E Schadt & Gang Fang (Source: Nature Biotechnology)
Source: Nature Biotechnology - December 11, 2017 Category: Biotechnology Authors: John Beaulaurier Shijia Zhu Gintaras Deikus Ilaria Mogno Xue-Song Zhang Austin Davis-Richardson Ronald Canepa Eric W Triplett Jeremiah J Faith Robert Sebra Eric E Schadt Gang Fang Tags: Research Source Type: research
People
Nature Biotechnology 35, 1216 (2017).
doi:10.1038/nbt.4041 (Source: Nature Biotechnology)
Source: Nature Biotechnology - December 8, 2017 Category: Biotechnology Tags: Careers and Recruitment Source Type: research
Institutional culture is the key to team science
Nature Biotechnology 35, 1212 (2017).
doi:10.1038/nbt.4026
Authors: Sandra Soo-Jin Lee & Anna Jabloner
Institutional leadership in creating a culture of cooperation and pathways for multidisciplinary collaboration is critical to achieving the goals of academic translation and innovation. (Source: Nature Biotechnology)
Source: Nature Biotechnology - December 8, 2017 Category: Biotechnology Authors: Sandra Soo-Jin Lee Anna Jabloner Tags: Careers and Recruitment Source Type: research
