Rollout of high-priced cell and gene therapies forces payer rethink
Nature Biotechnology 36, 291 (2018).
doi:10.1038/nbt0418-291a
Author: Melanie Senior (Source: Nature Biotechnology)
Source: Nature Biotechnology - April 5, 2018 Category: Biotechnology Authors: Melanie Senior Tags: News Source Type: research
New drug for multidrug-resistant HIV
Nature Biotechnology 36, 291 (2018).
doi:10.1038/nbt0418-291b (Source: Nature Biotechnology)
Source: Nature Biotechnology - April 5, 2018 Category: Biotechnology Tags: News Source Type: research
FDA approves stroke-detecting AI software
Nature Biotechnology 36, 290 (2018).
doi:10.1038/nbt0418-290 (Source: Nature Biotechnology)
Source: Nature Biotechnology - April 5, 2018 Category: Biotechnology Tags: News Source Type: research
Roche pays $ 1.9 billion for Flatiron's army of electronic health record curators
Nature Biotechnology 36, 289 (2018).
doi:10.1038/nbt0418-289
Author: Justin Petrone (Source: Nature Biotechnology)
Source: Nature Biotechnology - April 5, 2018 Category: Biotechnology Authors: Justin Petrone Tags: News Source Type: research
The long view on sequencing
Nature Biotechnology 36, 287 (2018).
doi:10.1038/nbt.4125
Ultra-long read, single-molecule nanopore sequencers are beginning to find an expanding set of research applications in both human genomics and pathogenomics. (Source: Nature Biotechnology)
Source: Nature Biotechnology - April 5, 2018 Category: Biotechnology Tags: Editorial Source Type: research
Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors
Nature Biotechnology 36, 421 (2018).
doi:10.1038/nbt.4091
Authors: Laleh Haghverdi, Aaron T L Lun, Michael D Morgan & John C Marioni (Source: Nature Biotechnology)
Source: Nature Biotechnology - April 2, 2018 Category: Biotechnology Authors: Laleh Haghverdi Aaron T L Lun Michael D Morgan John C Marioni Tags: Research Source Type: research
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Nature Biotechnology 36, 411 (2018).
doi:10.1038/nbt.4096
Authors: Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi & Rahul Satija (Source: Nature Biotechnology)
Source: Nature Biotechnology - April 2, 2018 Category: Biotechnology Authors: Andrew Butler Paul Hoffman Peter Smibert Efthymia Papalexi Rahul Satija Tags: Research Source Type: research
Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain
Nature Biotechnology 36, 442 (2018).
doi:10.1038/nbt.4103
Authors: Bushra Raj, Daniel E Wagner, Aaron McKenna, Shristi Pandey, Allon M Klein, Jay Shendure, James A Gagnon & Alexander F Schier (Source: Nature Biotechnology)
Source: Nature Biotechnology - March 28, 2018 Category: Biotechnology Authors: Bushra Raj Daniel E Wagner Aaron McKenna Shristi Pandey Allon M Klein Jay Shendure James A Gagnon Alexander F Schier Tags: Research Source Type: research
Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection
Nature Biotechnology 36, 359 (2018).
doi:10.1038/nbt.4110
Authors: Rekha Seshadri, Sinead C Leahy, Graeme T Attwood, Koon Hoong Teh, Suzanne C Lambie, Adrian L Cookson, Emiley A Eloe-Fadrosh, Georgios A Pavlopoulos, Michalis Hadjithomas, Neha J Varghese, David Paez-Espino, Nikola Palevich, Peter H Janssen, Ron S Ronimus, Samantha Noel, Priya Soni, Kerri Reilly, Todd Atherly, Cherie Ziemer, Andre-Denis Wright, Suzanne Ishaq, Michael Cotta, Stephanie Thompson, Katie Crosley, Nest McKain, R John Wallace, Harry J Flint, Jennifer C Martin, Robert J Forster, Robert J Gruninger, Tim McAllister, Rosalind Gilbert, Diane Ouw...
Source: Nature Biotechnology - March 19, 2018 Category: Biotechnology Authors: Rekha Seshadri Sinead C Leahy Graeme T Attwood Koon Hoong Teh Suzanne C Lambie Adrian L Cookson Emiley A Eloe-Fadrosh Georgios A Pavlopoulos Michalis Hadjithomas Neha J Varghese David Paez-Espino Nikola Palevich Peter H Janssen Ron S Ronimus Samantha Noel Tags: Research Source Type: research
Engineered promoters enable constant gene expression at any copy number in bacteria
Nature Biotechnology 36, 352 (2018).
doi:10.1038/nbt.4111
Authors: Thomas H Segall-Shapiro, Eduardo D Sontag & Christopher A Voigt
The internal environment of growing cells is variable and dynamic, making it difficult to introduce reliable parts, such as promoters, for genetic engineering. Here, we applied control-theoretic ideas to design promoters that maintained constant levels of expression at any copy number. Theory predicts that independence to copy number can be achieved by using an incoherent feedforward loop (iFFL) if the negative regulation is perfectly non-cooperative. We engineered iFFLs into Escher...
Source: Nature Biotechnology - March 19, 2018 Category: Biotechnology Authors: Thomas H Segall-Shapiro Eduardo D Sontag Christopher A Voigt Tags: Research Source Type: research
Phase 1 clinical study of an embryonic stem cell – derived retinal pigment epithelium patch in age-related macular degeneration
Nature Biotechnology 36, 328 (2018).
doi:10.1038/nbt.4114
Authors: Lyndon da Cruz, Kate Fynes, Odysseas Georgiadis, Julie Kerby, Yvonne H Luo, Ahmad Ahmado, Amanda Vernon, Julie T Daniels, Britta Nommiste, Shazeen M Hasan, Sakina B Gooljar, Amanda-Jayne F Carr, Anthony Vugler, Conor M Ramsden, Magda Bictash, Mike Fenster, Juliette Steer, Tricia Harbinson, Anna Wilbrey, Adnan Tufail, Gang Feng, Mark Whitlock, Anthony G Robson, Graham E Holder, Mandeep S Sagoo, Peter T Loudon, Paul Whiting & Peter J Coffey (Source: Nature Biotechnology)
Source: Nature Biotechnology - March 19, 2018 Category: Biotechnology Authors: Lyndon da Cruz Kate Fynes Odysseas Georgiadis Julie Kerby Yvonne H Luo Ahmad Ahmado Amanda Vernon Julie T Daniels Britta Nommiste Shazeen M Hasan Sakina B Gooljar Amanda-Jayne F Carr Anthony Vugler Conor M Ramsden Magda Bictash Mike Fenster Juliette Steer Tags: Research Source Type: research
Base editing with a Cpf1 – cytidine deaminase fusion
Nature Biotechnology 36, 324 (2018).
doi:10.1038/nbt.4102
Authors: Xiaosa Li, Ying Wang, Yajing Liu, Bei Yang, Xiao Wang, Jia Wei, Zongyang Lu, Yuxi Zhang, Jing Wu, Xingxu Huang, Li Yang & Jia Chen (Source: Nature Biotechnology)
Source: Nature Biotechnology - March 19, 2018 Category: Biotechnology Authors: Xiaosa Li Ying Wang Yajing Liu Bei Yang Xiao Wang Jia Wei Zongyang Lu Yuxi Zhang Jing Wu Xingxu Huang Li Yang Jia Chen Tags: Research Source Type: research
Linear assembly of a human centromere on the Y chromosome
Nature Biotechnology 36, 321 (2018).
doi:10.1038/nbt.4109
Authors: Miten Jain, Hugh E Olsen, Daniel J Turner, David Stoddart, Kira V Bulazel, Benedict Paten, David Haussler, Huntington F Willard, Mark Akeson & Karen H Miga (Source: Nature Biotechnology)
Source: Nature Biotechnology - March 19, 2018 Category: Biotechnology Authors: Miten Jain Hugh E Olsen Daniel J Turner David Stoddart Kira V Bulazel Benedict Paten David Haussler Huntington F Willard Mark Akeson Karen H Miga Tags: Research Source Type: research
People
Nature Biotechnology 36, 286 (2018).
doi:10.1038/nbt.4100 (Source: Nature Biotechnology)
Source: Nature Biotechnology - March 6, 2018 Category: Biotechnology Tags: Careers and Recruitment Source Type: research
Evidence for a mental health crisis in graduate education
Nature Biotechnology 36, 282 (2018).
doi:10.1038/nbt.4089
Authors: Teresa M Evans, Lindsay Bira, Jazmin Beltran Gastelum, L Todd Weiss & Nathan L Vanderford
With mental illness a growing concern within graduate education, data from a new survey should prompt both academia and policy makers to consider intervention strategies. (Source: Nature Biotechnology)
Source: Nature Biotechnology - March 6, 2018 Category: Biotechnology Authors: Teresa M Evans Lindsay Bira Jazmin Beltran Gastelum L Todd Weiss Nathan L Vanderford Tags: Careers and Recruitment Source Type: research
