First rounders: Stelios Papadopoulos
Nature Biotechnology 35, 1004 (2017).
doi:10.1038/nbt.3995 (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 9, 2017 Category: Biotechnology Tags: News Source Type: research
Spanish group defeats Shkreli in Chagas voucher race
Nature Biotechnology 35, 1003 (2017).
doi:10.1038/nbt1117-1003
Author: Lisa Melton (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 9, 2017 Category: Biotechnology Authors: Lisa Melton Tags: News Source Type: research
Allergan's Mohawk evergreening patent deal draws criticism, but ultimately may flop
Nature Biotechnology 35, 1002 (2017).
doi:10.1038/nbt1117-1002
Author: Eva von Schaper (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 9, 2017 Category: Biotechnology Authors: Eva von Schaper Tags: News Source Type: research
Age-related macular degeneration foils drugmakers
Nature Biotechnology 35, 1000 (2017).
doi:10.1038/nbt1117-1000
Author: Elie Dolgin (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 9, 2017 Category: Biotechnology Authors: Elie Dolgin Tags: News Source Type: research
Duchenne drug clings on for FDA nod
Nature Biotechnology 35, 999 (2017).
doi:10.1038/nbt1117-999 (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 9, 2017 Category: Biotechnology Tags: News Source Type: research
First AAV gene therapy poised for landmark approval
Nature Biotechnology 35, 998 (2017).
doi:10.1038/nbt1117-998
Author: Eric Smalley (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 9, 2017 Category: Biotechnology Authors: Eric Smalley Tags: News Source Type: research
RET-oncogene-targeting drugs draw notice
Nature Biotechnology 35, 996 (2017).
doi:10.1038/nbt1117-996 (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 9, 2017 Category: Biotechnology Tags: News Source Type: research
With Alnylam's amyloidosis success, RNAi approval hopes soar
Nature Biotechnology 35, 995 (2017).
doi:10.1038/nbt1117-995
Author: Cormac Sheridan (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 9, 2017 Category: Biotechnology Authors: Cormac Sheridan Tags: News Source Type: research
Humans 2.0
Nature Biotechnology 35, 993 (2017).
doi:10.1038/nbt.4018
Of the germline engineering approaches, mitochondrial replacement, rather than gene editing, is poised to have the greatest impact on our lives. (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 9, 2017 Category: Biotechnology Tags: Editorial Source Type: research
In this issue
Nature Biotechnology 35, vii (2017).
doi:10.1038/nbt.4019
Authors: Kathy Aschheim, Michael Francisco & Andrew Marshall (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 9, 2017 Category: Biotechnology Authors: Kathy Aschheim Michael Francisco Andrew Marshall Tags: In This Issue Source Type: research
Cell-type-specific metabolic labeling of nascent proteomes in vivo
We report the development of a transgenic mouse line where Cre-recombinase-induced expression of a mutant methionyl-tRNA synthetase (L274G) enables the cell-type-specific labeling of nascent proteins with a non-canonical amino-acid and click chemistry. Using immunoblotting, imaging and mass spectrometry, we use our transgenic mouse to label and analyze proteins in excitatory principal neurons and Purkinje neurons in vitro (brain slices) and in vivo. We discover more than 200 proteins that are differentially regulated in hippocampal excitatory neurons by exposing mice to an environment with enriched sensory cues. Our approa...
Source: Nature Biotechnology - November 6, 2017 Category: Biotechnology Authors: Beatriz Alvarez-Castelao Christoph T Schanzenb ä cher Cyril Hanus Caspar Glock Susanne tom Dieck Aline R D ö rrbaum Ina Bartnik Belquis Nassim-Assir Elena Ciirdaeva Anke Mueller Daniela C Dieterich David A Tirrell Julian D Langer Erin M Schuman Tags: Research Source Type: research
Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro
Nature Biotechnology 35, 1188 (2017).
doi:10.1038/nbt.4004
Authors: Thomas M Schmitt, David H Aggen, Kumiko Ishida-Tsubota, Sebastian Ochsenreither, David M Kranz & Philip D Greenberg (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 6, 2017 Category: Biotechnology Authors: Thomas M Schmitt David H Aggen Kumiko Ishida-Tsubota Sebastian Ochsenreither David M Kranz Philip D Greenberg Tags: Research Source Type: research
Highly accurate fluorogenic DNA sequencing with information theory – based error correction
Nature Biotechnology 35, 1170 (2017).
doi:10.1038/nbt.3982
Authors: Zitian Chen, Wenxiong Zhou, Shuo Qiao, Li Kang, Haifeng Duan, X Sunney Xie & Yanyi Huang (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 6, 2017 Category: Biotechnology Authors: Zitian Chen Wenxiong Zhou Shuo Qiao Li Kang Haifeng Duan X Sunney Xie Yanyi Huang Tags: Research Source Type: research
Tuning up T-cell receptors
Nature Biotechnology 35, 1145 (2017).
doi:10.1038/nbt.4009
Authors: C Garrett Rappazzo & Michael E Birnbaum
T-cell receptors with higher affinity for tumor antigens are discovered by harnessing T-cell development. (Source: Nature Biotechnology)
Source: Nature Biotechnology - November 6, 2017 Category: Biotechnology Authors: C Garrett Rappazzo Michael E Birnbaum Tags: News and Views Source Type: research
DNA sequencing at ultra-high fidelity
Nature Biotechnology 35, 1143 (2017).
doi:10.1038/nbt.4001
Author: Robert Sebra
Built-in error-correction and novel fluorogenic chemistry open a path to perfect read quality. (Source: Nature Biotechnology)
Source: Nature Biotechnology - October 30, 2017 Category: Biotechnology Authors: Robert Sebra Tags: News and Views Source Type: research
