Shotgun metagenomics, from sampling to analysis
Nature Biotechnology 35, 833 (2017).
doi:10.1038/nbt.3935
Authors: Christopher Quince, Alan W Walker, Jared T Simpson, Nicholas J Loman & Nicola Segata (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 12, 2017 Category: Biotechnology Authors: Christopher Quince Alan W Walker Jared T Simpson Nicholas J Loman Nicola Segata Tags: Research Source Type: research
Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities
Nature Biotechnology 35, 983 (2017).
doi:10.1038/nbt.3955
Authors: John D Lapek, Patricia Greninger, Robert Morris, Arnaud Amzallag, Iulian Pruteanu-Malinici, Cyril H Benes & Wilhelm Haas
The formation of protein complexes and the co-regulation of the cellular concentrations of proteins are essential mechanisms for cellular signaling and for maintaining homeostasis. Here we use isobaric-labeling multiplexed proteomics to analyze protein co-regulation and show that this allows the identification of protein–protein associations with high accuracy. We apply this 'interactome mapping by high-throughput quanti...
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Authors: John D Lapek Patricia Greninger Robert Morris Arnaud Amzallag Iulian Pruteanu-Malinici Cyril H Benes Wilhelm Haas Tags: Research Source Type: research
Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring
Nature Biotechnology 35, 977 (2017).
doi:10.1038/nbt.3964
Authors: Klaus Eyer, Raphaël C L Doineau, Carlos E Castrillon, Luis Briseño-Roa, Vera Menrath, Guillaume Mottet, Patrick England, Alexei Godina, Elodie Brient-Litzler, Clément Nizak, Allan Jensen, Andrew D Griffiths, Jérôme Bibette, Pierre Bruhns & Jean Baudry
Studies of the dynamics of the antibody-mediated immune response have been hampered by the absence of quantitative, high-throughput systems to analyze individual antibody-secreting cells. Here we describe a simple microfluidic system, DropMap, in which single cells are comp...
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Authors: Klaus Eyer Rapha ë l C L Doineau Carlos E Castrillon Luis Brise ñ o-Roa Vera Menrath Guillaume Mottet Patrick England Alexei Godina Elodie Brient-Litzler Cl é ment Nizak Allan Jensen Andrew D Griffiths J é r ô me Bibette Pierre Bruhns Jean Baudry Tags: Research Source Type: research
Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries
Nature Biotechnology 35, 960 (2017).
doi:10.1038/nbt.3963
Authors: Joel W Blanchard, Jia Xie, Nadja El-Mecharrafie, Simon Gross, Sohyon Lee, Richard A Lerner & Kristin K Baldwin (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Authors: Joel W Blanchard Jia Xie Nadja El-Mecharrafie Simon Gross Sohyon Lee Richard A Lerner Kristin K Baldwin Tags: Research Source Type: research
Analysis of somatic microsatellite indels identifies driver events in human tumors
Nature Biotechnology 35, 951 (2017).
doi:10.1038/nbt.3966
Authors: Yosef E Maruvka, Kent W Mouw, Rosa Karlic, Prasanna Parasuraman, Atanas Kamburov, Paz Polak, Nicholas J Haradhvala, Julian M Hess, Esther Rheinbay, Yehuda Brody, Amnon Koren, Lior Z Braunstein, Alan D'Andrea, Michael S Lawrence, Adam Bass, Andre Bernards, Franziska Michor & Gad Getz (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Authors: Yosef E Maruvka Kent W Mouw Rosa Karlic Prasanna Parasuraman Atanas Kamburov Paz Polak Nicholas J Haradhvala Julian M Hess Esther Rheinbay Yehuda Brody Amnon Koren Lior Z Braunstein Alan D'Andrea Michael S Lawrence Adam Bass Andre Bernards Franziska Micho Tags: Research Source Type: research
Mapping the secrets of the antibody pool
Nature Biotechnology 35, 921 (2017).
doi:10.1038/nbt.3972
Authors: Jonathan R McDaniel, Gregory C Ippolito & George Georgiou
The progression of antibody-mediated immunity can now be monitored at high-throughput on a single-cell level. (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Authors: Jonathan R McDaniel Gregory C Ippolito George Georgiou Tags: News and Views Source Type: research
People
Nature Biotechnology 35, 888 (2017).
doi:10.1038/nbt.3969 (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Tags: Careers and Recruitment Source Type: research
What faculty hiring committees want
Nature Biotechnology 35, 885 (2017).
doi:10.1038/nbt.3962
Authors: Charles B Wright & Nathan L Vanderford
PhD trainees aspiring to become faculty need to know the credentials search committees value most in an applicant. (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Authors: Charles B Wright Nathan L Vanderford Tags: Careers and Recruitment Source Type: research
Precision editing in the human embryo
Nature Biotechnology 35, 832 (2017).
doi:10.1038/nbt.3965
Author: Kathy Aschheim (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Authors: Kathy Aschheim Tags: News and Views Source Type: research
Mouse phenotyping sheds light on rare disease
Nature Biotechnology 35, 831 (2017).
doi:10.1038/nbt.3959
Author: Sarah Perry (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Authors: Sarah Perry Tags: News and Views Source Type: research
Research Highlights
Nature Biotechnology 35, 830 (2017).
doi:10.1038/nbt.3961 (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Tags: News and Views Source Type: research
Interpreting the T-cell receptor repertoire
Nature Biotechnology 35, 829 (2017).
doi:10.1038/nbt.3957
Author: Robert A Holt
T cell receptor sequence motifs can predict T cell antigen specificity. (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Authors: Robert A Holt Tags: News and Views Source Type: research
Tagging activated neurons with light
Nature Biotechnology 35, 827 (2017).
doi:10.1038/nbt.3954
Authors: Dheeraj S Roy, Teruhiro Okuyama & Susumu Tonegawa
Two new protein tools translate neuronal activity into gene expression during a light-defined time window. (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Authors: Dheeraj S Roy Teruhiro Okuyama Susumu Tonegawa Tags: News and Views Source Type: research
Recent patents related to clinical applications of sequencing
Nature Biotechnology 35, 826 (2017).
doi:10.1038/nbt.3970 (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Tags: Feature Source Type: research
After Myriad, what makes a gene patent claim 'markedly different' from nature?
Nature Biotechnology 35, 820 (2017).
doi:10.1038/nbt.3953
Authors: Mateo Aboy, Johnathon Liddicoat, Kathleen Liddell, Matthew Jordan & Cristina Crespo
Examining the types of claim amendments that have transformed isolated gene claims from patent-ineligible into eligible subject matter provides clarity into the threshold of eligibility for gene-related patents. (Source: Nature Biotechnology)
Source: Nature Biotechnology - September 11, 2017 Category: Biotechnology Authors: Mateo Aboy Johnathon Liddicoat Kathleen Liddell Matthew Jordan Cristina Crespo Tags: Feature Source Type: research
