Gut bacteria link to immunotherapy sparks interest
Nature Biotechnology 36, 121 (2018).
doi:10.1038/nbt0218-121
Author: Brian Owens (Source: Nature Biotechnology)
Source: Nature Biotechnology - February 6, 2018 Category: Biotechnology Authors: Brian Owens Tags: News Source Type: research
FDA warns public of dangers of DIY gene therapy
Nature Biotechnology 36, 119 (2018).
doi:10.1038/nbt0218-119
Author: Eric Smalley (Source: Nature Biotechnology)
Source: Nature Biotechnology - February 6, 2018 Category: Biotechnology Authors: Eric Smalley Tags: News Source Type: research
No research in Correspondence
Nature Biotechnology 36, 117 (2018).
doi:10.1038/nbt.4085
Nature Biotechnology will no longer publish research in its Correspondence section. (Source: Nature Biotechnology)
Source: Nature Biotechnology - February 6, 2018 Category: Biotechnology Tags: Editorial Source Type: research
A less than ideal Deal
Nature Biotechnology 36, 117 (2018).
doi:10.1038/nbt.4084
The UK government's strategic plan for the life sciences is short on ambition and capital. (Source: Nature Biotechnology)
Source: Nature Biotechnology - February 6, 2018 Category: Biotechnology Tags: Editorial Source Type: research
Nanopore sequencing and assembly of a human genome with ultra-long reads
Nature Biotechnology 36, 338 (2018).
doi:10.1038/nbt.4060
Authors: Miten Jain, Sergey Koren, Karen H Miga, Josh Quick, Arthur C Rand, Thomas A Sasani, John R Tyson, Andrew D Beggs, Alexander T Dilthey, Ian T Fiddes, Sunir Malla, Hannah Marriott, Tom Nieto, Justin O'Grady, Hugh E Olsen, Brent S Pedersen, Arang Rhie, Hollian Richardson, Aaron R Quinlan, Terrance P Snutch, Louise Tee, Benedict Paten, Adam M Phillippy, Jared T Simpson, Nicholas J Loman & Matthew Loose (Source: Nature Biotechnology)
Source: Nature Biotechnology - January 29, 2018 Category: Biotechnology Authors: Miten Jain Sergey Koren Karen H Miga Josh Quick Arthur C Rand Thomas A Sasani John R Tyson Andrew D Beggs Alexander T Dilthey Ian T Fiddes Sunir Malla Hannah Marriott Tom Nieto Justin O'Grady Hugh E Olsen Brent S Pedersen Arang Rhie Hollian Richardson Aar Tags: Research Source Type: research
A highly specific SpCas9 variant is identified by in vivo screening in yeast
Nature Biotechnology 36, 265 (2018).
doi:10.1038/nbt.4066
Authors: Antonio Casini, Michele Olivieri, Gianluca Petris, Claudia Montagna, Giordano Reginato, Giulia Maule, Francesca Lorenzin, Davide Prandi, Alessandro Romanel, Francesca Demichelis, Alberto Inga & Anna Cereseto
Despite the utility of CRISPR–Cas9 nucleases for genome editing, the potential for off-target activity limits their application, especially for therapeutic purposes. We developed a yeast-based assay to identify optimized Streptococcus pyogenes Cas9 (SpCas9) variants that enables simultaneous evaluation of on- and off-target activity. W...
Source: Nature Biotechnology - January 29, 2018 Category: Biotechnology Authors: Antonio Casini Michele Olivieri Gianluca Petris Claudia Montagna Giordano Reginato Giulia Maule Francesca Lorenzin Davide Prandi Alessandro Romanel Francesca Demichelis Alberto Inga Anna Cereseto Tags: Research Source Type: research
Deep learning improves prediction of CRISPR – Cpf1 guide RNA activity
Nature Biotechnology 36, 239 (2018).
doi:10.1038/nbt.4061
Authors: Hui Kwon Kim, Seonwoo Min, Myungjae Song, Soobin Jung, Jae Woo Choi, Younggwang Kim, Sangeun Lee, Sungroh Yoon & Hyongbum (Henry) Kim (Source: Nature Biotechnology)
Source: Nature Biotechnology - January 29, 2018 Category: Biotechnology Authors: Hui Kwon Kim Seonwoo Min Myungjae Song Soobin Jung Jae Woo Choi Younggwang Kim Sangeun Lee Sungroh Yoon Hyongbum (Henry) Kim Tags: Research Source Type: research
Fresh from the biotech pipeline — 2017
Nature Biotechnology 36, 131 (2018).
doi:10.1038/nbt.4068
Author: Chris Morrison
A positive regulatory environment, combined with a raft of drug approvals that included the first US gene therapy, buoyed the sector in 2017. The FDA's flexibility and focus on marketplace competition is likely to galvanize innovators in the coming year. Chris Morrison reports. (Source: Nature Biotechnology)
Source: Nature Biotechnology - January 22, 2018 Category: Biotechnology Authors: Chris Morrison Tags: News Source Type: research
Visualizing detailed postdoctoral employment trends using a new career outcome taxonomy
Nature Biotechnology 36, 197 (2018).
doi:10.1038/nbt.4059
Authors: Hong Xu, Richard S T Gilliam, Shyamal D Peddada, Gregory M Buchold & Tammy R L Collins
A standard taxonomy and visualization methods can provide postdoctoral scholars with tools to critically evaluate their career prospects. (Source: Nature Biotechnology)
Source: Nature Biotechnology - January 15, 2018 Category: Biotechnology Authors: Hong Xu Richard S T Gilliam Shyamal D Peddada Gregory M Buchold Tammy R L Collins Tags: Careers and Recruitment Source Type: research
Dual gene activation and knockout screen reveals directional dependencies in genetic networks
Nature Biotechnology 36, 170 (2018).
doi:10.1038/nbt.4062
Authors: Michael Boettcher, Ruilin Tian, James A Blau, Evan Markegard, Ryan T Wagner, David Wu, Xiulei Mo, Anne Biton, Noah Zaitlen, Haian Fu, Frank McCormick, Martin Kampmann & Michael T McManus (Source: Nature Biotechnology)
Source: Nature Biotechnology - January 15, 2018 Category: Biotechnology Authors: Michael Boettcher Ruilin Tian James A Blau Evan Markegard Ryan T Wagner David Wu Xiulei Mo Anne Biton Noah Zaitlen Haian Fu Frank McCormick Martin Kampmann Michael T McManus Tags: Research Source Type: research
Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells
Nature Biotechnology 36, 160 (2018).
doi:10.1038/nbt.4047
Authors: Alexander S Cheung, David K Y Zhang, Sandeep T Koshy & David J Mooney (Source: Nature Biotechnology)
Source: Nature Biotechnology - January 15, 2018 Category: Biotechnology Authors: Alexander S Cheung David K Y Zhang Sandeep T Koshy David J Mooney Tags: Research Source Type: research
People
Nature Biotechnology 36, 116 (2018).
doi:10.1038/nbt.4065 (Source: Nature Biotechnology)
Source: Nature Biotechnology - January 10, 2018 Category: Biotechnology Tags: Careers and Recruitment Source Type: research
Precision oncology in the age of integrative genomics
Nature Biotechnology 36, 46 (2018).
doi:10.1038/nbt.4017
Authors: Chandan Kumar-Sinha & Arul M Chinnaiyan (Source: Nature Biotechnology)
Source: Nature Biotechnology - January 10, 2018 Category: Biotechnology Authors: Chandan Kumar-Sinha Arul M Chinnaiyan Tags: Research Source Type: research
Research Highlights
Nature Biotechnology 36, 45 (2018).
doi:10.1038/nbt.4058 (Source: Nature Biotechnology)
Source: Nature Biotechnology - January 10, 2018 Category: Biotechnology Tags: News and Views Source Type: research
RNA-targeting CRISPR comes of age
Nature Biotechnology 36, 44 (2018).
doi:10.1038/nbt.4054
Author: V Narry Kim
Cas13 can be harnessed for RNA knockdown and editing in mammalian cells, opening up a range of applications in RNA biology. (Source: Nature Biotechnology)
Source: Nature Biotechnology - January 10, 2018 Category: Biotechnology Authors: V Narry Kim Tags: News and Views Source Type: research
