Molecular and Cellular Neuroscience This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus
Publication date: Available online 4 July 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Jacqueline E. McDermott, Dena Goldblatt, Suzanne ParadisAbstractTo understand how proper circuit formation and function is established in the mammalian brain, it is necessary to define the genes and signaling pathways that instruct excitatory and inhibitory synapse development. We previously demonstrated that the ligand-receptor pair, Sema4D and Plexin-B1, regulates inhibitory synapse development on an unprecedentedly fast time-scale while having no effect on excitatory synapse development. Here, we report previously undescr...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research

Identification and characterization of two novel alternatively spliced E2F1 transcripts in the rat CNS
Publication date: October 2018Source: Molecular and Cellular Neuroscience, Volume 92Author(s): Dan P. Jackson, Jenhao H. Ting, Paul D. Pozniak, Claire Meurice, Stephanie S. Schleidt, Anh Dao, Amy H. Lee, Eva Klinman, Kelly L. Jordan-SciuttoAbstractE2F1 is a transcription factor classically known to regulate G0/G1 to S phase progression in the cell cycle. In addition, E2F1 also regulates a wide range of apoptotic genes and thus has been well studied in the context of neuronal death and neurodegenerative diseases. However, its function and regulation in the mature central nervous system are not well understood. Alternative s...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research

Urate mitigates oxidative stress and motor neuron toxicity of astrocytes derived from ALS-linked SOD1G93A mutant mice
Publication date: October 2018Source: Molecular and Cellular Neuroscience, Volume 92Author(s): Rachit Bakshi, Yuehang Xu, Kaly A. Mueller, Xiqun Chen, Eric Granucci, Sabrina Paganoni, Ghazaleh Sadri-Vakili, Michael A. SchwarzschildAbstractDominant mutations in an antioxidant enzyme superoxide dismutase-1 (SOD1) cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease characterized by loss of motor neurons. Oxidative stress has also been linked to many of the neurodegenerative diseases and is likely a central mechanism of motor neuron death in ALS. Astrocytes derived from mutant SOD1G93A mouse mod...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research

Partial loss of ATP13A2 causes selective gliosis independent of robust lipofuscinosis
This study suggests that heterozygous loss-of-function mutations in ATP13A2 are likely harmful and indicates that glial involvement in the disease process may be an early event that positions the CNS for subsequent disease development. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research

Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus
Publication date: Available online 4 July 2018 Source:Molecular and Cellular Neuroscience Author(s): Jacqueline E. McDermott, Dena Goldblatt, Suzanne Paradis To understand how proper circuit formation and function is established in the mammalian brain, it is necessary to define the genes and signaling pathways that instruct excitatory and inhibitory synapse development. We previously demonstrated that the ligand-receptor pair, Sema4D and Plexin-B1, regulates inhibitory synapse development on an unprecedentedly fast time-scale while having no effect on excitatory synapse development. Here, we report previously undescri...
Source: Molecular and Cellular Neuroscience - July 4, 2018 Category: Neuroscience Source Type: research

Depletion of astrocytic transglutaminase 2 improves injury outcomes
In this study we show that knocking down TG2 in astrocytes significantly increases their ability to protect neurons from oxygen glucose deprivation (OGD)/reperfusion injury. To begin to understand how deletion of TG2 in astrocytes improves their ability to protect neurons from injury, we performed transcriptome analysis of wild type and TG2−/− astrocytes. TG2 deletion resulted in alterations in genes involved in extracellular matrix remodeling, cell adhesion and axon growth/guidance. In addition, the majority of genes that showed increases in the TG2−/− astrocytes had predicted cJun/AP-1 binding motifs in their pro...
Source: Molecular and Cellular Neuroscience - July 1, 2018 Category: Neuroscience Source Type: research

Involvement of l-afadin, but not s-afadin, in the formation of puncta adherentia junctions of hippocampal synapse
Publication date: Available online 30 June 2018 Source:Molecular and Cellular Neuroscience Author(s): Tomohiko Maruo, Shotaro Sakakibara, Muneaki Miyata, Yu Itoh, Souichi Kurita, Kenji Mandai, Takuya Sasaki, Yoshimi Takai A hippocampal mossy fiber synapse has a complex structure in which presynaptic boutons attach to the dendritic trunk by puncta adherentia junctions (PAJs) and wrap multiply-branched spines, forming synaptic junctions. It was previously shown that afadin regulates the formation of the PAJs cooperatively with nectin-1, nectin-3, and N-cadherin. Afadin is a nectin-binding protein with two splice va...
Source: Molecular and Cellular Neuroscience - June 30, 2018 Category: Neuroscience Source Type: research

Semaphorin 3A as an inhibitive factor for migration of olfactory ensheathing cells through cofilin activation is involved in formation of olfactory nerve layer
Publication date: Available online 27 June 2018 Source:Molecular and Cellular Neuroscience Author(s): Ying Wang, Xiaomei Bao, Shiyang Wu, Xiya Shen, Fan Zhang, Zhaoting Lv, Qian Wu, Changnan Xie, Huitao Liu, Jian Lin, Honglin Teng, Zhihui Huang Olfactory ensheathing cells (OECs) migrate from olfactory epithelium towards olfactory bulb (OB), contributing to formation of the presumptive olfactory nerve layer during development. However, it remains unclear that molecular mechanism of regulation of OEC migration in OB. In the present study, we found that OECs highly expressed the receptors of semaphorin 3A (Sema3...
Source: Molecular and Cellular Neuroscience - June 27, 2018 Category: Neuroscience Source Type: research

Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease
This study investigated whether these and other alterations in the cerebrovascular system associated with AD can be prevented by long-term dietary supplementation with the antioxidant ubiquinol (Ub) stabilized with Kaneka QH P30 powder containing ascorbic acid (ASC) in a mouse model of advanced AD (3 × Tg-AD mice, 12 months old). Animals were treated from prodromal stages of disease (3 months of age) with standard chow without or with Ub + ASC or ASC-containing vehicle and compared to wild-type (WT) mice. The number of β-amyloid (Aβ) plaques in the hippocampus and entorhinal cortex was higher in female than ...
Source: Molecular and Cellular Neuroscience - June 26, 2018 Category: Neuroscience Source Type: research

Identification and characterization of two novel alternatively spliced E2F1 transcripts in the rat CNS
Publication date: Available online 22 June 2018 Source:Molecular and Cellular Neuroscience Author(s): Dan P. Jackson, Jenhao H. Ting, Paul D. Pozniak, Claire Meurice, Stephanie S. Schleidt, Anh Dao, Amy H. Lee, Eva Klinman, Kelly L. Jordan-Sciutto E2F1 is a transcription factor classically known to regulate G0/G1 to S phase progression in the cell cycle. In addition, E2F1 also regulates a wide range of apoptotic genes and thus has been well studied in the context of neuronal death and neurodegenerative diseases. However, its function and regulation in the mature central nervous system are not well understood. Al...
Source: Molecular and Cellular Neuroscience - June 23, 2018 Category: Neuroscience Source Type: research

Urate mitigates oxidative stress and motor neuron toxicity of astrocytes derived from ALS-linked SOD1G93A mutant mice
Publication date: Available online 18 June 2018 Source:Molecular and Cellular Neuroscience Author(s): Rachit Bakshi, Yuehang Xu, Kaly A. Mueller, Xiqun Chen, Eric Granucci, Sabrina Paganoni, Ghazaleh Sadri-Vakili, Michael A. Schwarzschild Dominant mutations in an antioxidant enzyme superoxide dismutase-1 (SOD1) cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease characterized by loss of motor neurons. Oxidative stress has also been linked to many of the neurodegenerative diseases and is likely a central mechanism of motor neuron death in ALS. Astrocytes derived from mutant SOD1 G93...
Source: Molecular and Cellular Neuroscience - June 19, 2018 Category: Neuroscience Source Type: research

The association of spinophilin with disks large-associated protein 3 (SAPAP3) is regulated by metabotropic glutamate receptor (mGluR) 5
Publication date: Available online 14 June 2018 Source:Molecular and Cellular Neuroscience Author(s): Cameron W. Morris, Darryl S. Watkins, Asma B. Salek, Michael C. Edler, Anthony J. Baucum Spinophilin is the most abundant protein phosphatase 1 targeting protein in the postsynaptic density of dendritic spines. Spinophilin associates with myriad synaptic proteins to regulate normal synaptic communication; however, the full complement of spinophilin interacting proteins and mechanisms regulating spinophilin interactions are unclear. Here we validate an association between spinophilin and the scaffolding protein, disk...
Source: Molecular and Cellular Neuroscience - June 15, 2018 Category: Neuroscience Source Type: research

α4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males
Publication date: July 2018 Source:Molecular and Cellular Neuroscience, Volume 90 Author(s): Yi-Wen Chen, Hannah Actor-Engel, Chiye Aoki Activity-based anorexia (ABA) is an animal model of anorexia nervosa, a mental illness with highest mortality and with onset that is most frequently during adolescence. We questioned whether vulnerability of adolescent mice to ABA differs between sexes and whether individual differences in resilience are causally linked to α4βδ-GABAAR expression. C57BL6/J WT and α4-KO adolescent male and female mice underwent ABA induction by combining wheel access with food restriction. ABA vuln...
Source: Molecular and Cellular Neuroscience - June 15, 2018 Category: Neuroscience Source Type: research

Partial loss of ATP13A2 causes selective gliosis independent of robust lipofuscinosis
This study suggests that heterozygous loss-of-function mutations in ATP13A2 are likely harmful and indicates that glial involvement in the disease process may be an early event that positions the CNS for subsequent disease development. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - June 2, 2018 Category: Neuroscience Source Type: research

AMPA receptor complex constituents: Control of receptor assembly, membrane trafficking and subcellular localization
Publication date: Available online 26 May 2018 Source:Molecular and Cellular Neuroscience Author(s): Eric Jacobi, Jakob von Engelhardt Fast excitatory transmission at synapses of the central nervous system is mainly mediated by AMPA receptors (AMPARs). Synaptic AMPAR number and function correlates with synaptic strength. AMPARs are thus key proteins of activity-dependent plasticity in neuronal communication. Up- or down-regulation of synaptic AMPAR number is a tightly controlled dynamic process that involves export of receptors from the endoplasmic reticulum (ER) and Golgi apparatus, exocytosis and endocytosis as well ...
Source: Molecular and Cellular Neuroscience - May 27, 2018 Category: Neuroscience Source Type: research