Molecular and Cellular Neuroscience This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Differential gene regulatory plasticity between upper and lower layer cortical excitatory neurons
Publication date: Available online 23 May 2018 Source:Molecular and Cellular Neuroscience Author(s): Lingling Yang, Liuzheng Chen, Chunlin Cai, Hong Li Neocortical projection neurons consist of intracortical connected upper layer (UL, layer II–IV) neurons and subcortical connected lower layer (LL, layer V–VI) neurons. Afferent activity from the thalamus regulates layer-specific gene expression during postnatal development, which is critical for the formation of proper neocortical cytoarchitecture. Here, we show that activity-dependent gene regulation is confined to UL cortical neurons, but not LL neurons, and tha...
Source: Molecular and Cellular Neuroscience - May 25, 2018 Category: Neuroscience Source Type: research

Depressed mitochondrial function and electron transport Complex II-mediated H2O2 production in the cortex of type 1 diabetic rodents
Conclusion Deficits in mitochondrial function, dynamics, and antioxidant capabilities putatively mediated through sub-optimal AMPK/SIRT/PGC-1α signaling, are involved in the development of early sub-clinical neurodegeneration in the cortex under diabetic conditions. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - May 24, 2018 Category: Neuroscience Source Type: research

Dynamics, nanoscale organization, and function of synaptic adhesion molecules
Publication date: Available online 17 April 2018 Source:Molecular and Cellular Neuroscience Author(s): Ingrid Chamma, Olivier Thoumine Synaptic adhesion molecules not only provide a physical link between pre- and post-synaptic membranes, but also contribute to synaptic differentiation and plasticity by organizing functional elements, in particular neurotransmitter receptors. The wealth of existing adhesive protein families including many isoforms and splice variants, calls for systematic identification of the levels and exchange rates of each of those protein members at specific synapse types. Complementary to electron...
Source: Molecular and Cellular Neuroscience - May 22, 2018 Category: Neuroscience Source Type: research

⍺4-GABAA receptors of hippocampal pyramidal neurons are associated with resilience against activity-based anorexia for adolescent female mice but not for males
Publication date: Available online 22 April 2018 Source:Molecular and Cellular Neuroscience Author(s): Yi-Wen Chen, Hannah Actor-Engel, Chiye Aoki Activity-based anorexia (ABA) is an animal model of anorexia nervosa, a mental illness with highest mortality and with onset that is most frequently during adolescence. We questioned whether vulnerability of adolescent mice to ABA differs between sexes and whether individual differences in resilience are causally linked to alpha4betadelta-GABAAR expression. C57BL6/J WT and α4-KO adolescent male and female mice underwent ABA induction by combining wheel access with food res...
Source: Molecular and Cellular Neuroscience - May 22, 2018 Category: Neuroscience Source Type: research

Autophagy and lysosomal pathways in nervous system disorders
Publication date: Available online 3 May 2018 Source:Molecular and Cellular Neuroscience Author(s): Baris Bingol Autophagy is an evolutionarily conserved pathway for delivering cytoplasmic cargo to lysosomes for degradation. In its classically studied form, autophagy is a stress response induced by starvation to recycle building blocks for essential cellular processes. In addition, autophagy maintains basal cellular homeostasis by degrading endogenous substrates such as cytoplasmic proteins, protein aggregates, damaged organelles, as well as exogenous substrates such as bacteria and viruses. Given their important role i...
Source: Molecular and Cellular Neuroscience - May 22, 2018 Category: Neuroscience Source Type: research