Molecular and Cellular Neuroscience This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The corepressor CtBP2 is required for proper development of the mouse cerebral cortex
Publication date: Available online 10 March 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Esra Karaca, Xiaofei Li, Jakub Lewicki, Christina Neofytou, Nicolas Guérout, Fanie Barnabé-Heider, Ola Hermanson (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - March 12, 2020 Category: Neuroscience Source Type: research

Editorial Board
Publication date: March 2020Source: Molecular and Cellular Neuroscience, Volume 103Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - February 26, 2020 Category: Neuroscience Source Type: research

Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures
Publication date: Available online 12 February 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Claire A. de March, William B. Titlow, Tomoko Sengoku, Patrick Breheny, Hiroaki Matsunami, Timothy S. McClintockAbstractThe perception of odors relies on combinatorial codes consisting of odorant receptor (OR) response patterns to encode odor identity. Modulation of these patterns by odorant interactions at ORs potentially explains several olfactory phenomena: mixture suppression, unpredictable sensory outcomes, and the perception of odorant mixtures as unique objects. We determined OR response patterns to 4 odorants an...
Source: Molecular and Cellular Neuroscience - February 13, 2020 Category: Neuroscience Source Type: research

Functional heterogeneity in the pineal projection neurons of zebrafish
Publication date: Available online 3 February 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Dora Sapède, Clair Chaigne, Patrick Blader, Elise CauAbstractThe zebrafish pineal organ is a photoreceptive structure containing two main neuronal populations (photoreceptors and projections neurons). Here we describe a subpopulation of projection neurons that expresses the melanopsin gene, opn4xa. This new pineal cell type, that displays characteristics of both projection neurons and photoreceptors, share a similar dependency for BMP and Notch signalling pathways with classical non-photosensitive projection neurons (PN...
Source: Molecular and Cellular Neuroscience - February 4, 2020 Category: Neuroscience Source Type: research

Molecular dissection of TNFR-TNFα bidirectional signaling reveals both cooperative and antagonistic interactions with p75 neurotrophic factor receptor in axon patterning
Publication date: Available online 28 January 2020Source: Molecular and Cellular NeuroscienceAuthor(s): K.D. Kuhn, K. Edamura, N. Bhatia, I. Cheng, S.A. Clark, C.V. Haynes, D.L. Heffner, F. Kabir, J. Velasquez, A.J. Spano, C.D. Deppmann, A.B. KeelerAbstractDuring neural development, complex organisms rely on progressive and regressive events whereby axons, synapses, and neurons are overproduced followed by selective elimination of a portion of these components. Tumor necrosis factor α (TNFα) together with its cognate receptor (Tumor necrosis factor receptor 1; TNFR1) have been shown to play both regressive (i.e. forward ...
Source: Molecular and Cellular Neuroscience - January 29, 2020 Category: Neuroscience Source Type: research

Smart motors and cargo steering drive kinesin-mediated selective transport
Publication date: March 2020Source: Molecular and Cellular Neuroscience, Volume 103Author(s): Alec T. Nabb, Madeline Frank, Marvin BentleyAbstractNeurons are polarized cells, with dendrites and axons that require different complements of membrane proteins to fulfill their specialized functions. Membrane proteins are synthesized in the somatodendritic domain and delivered to their target membranes via long-range vesicle transport. Most anterograde vesicle transport is mediated by kinesin motors, but it is unclear how kinesins are targeted to axons or dendrites. Two main models have been proposed to explain kinesin selectivi...
Source: Molecular and Cellular Neuroscience - January 21, 2020 Category: Neuroscience Source Type: research

Autophagy modulates Aβ accumulation and formation of aggregates in yeast
We report that GFP-Aβ42 is sequestered and is selectively transported to vacuole for degradation and that autophagy is the prominent pathway for clearance of aggregates. Next, to identify genes that selectively promote the removal of Aβ42 aggregates, we screened levels of GFP-Aβ42 and non-aggregating GFP-Aβ42 (19:34) proteins in a panel of 192 autophagy mutants lacking genes involved in regulation and initiation of the pathway, cargo selection and degradation processes. The nutrient and stress signalling genes RRD1, SNF4, GCN4 and SSE1 were identified. Deletion of these genes impaired GFP-Aβ42 clearance and their over...
Source: Molecular and Cellular Neuroscience - January 19, 2020 Category: Neuroscience Source Type: research

Editorial Board
Publication date: January 2020Source: Molecular and Cellular Neuroscience, Volume 102Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - January 16, 2020 Category: Neuroscience Source Type: research

Identification of MAGUK scaffold proteins as intracellular binding partners of synaptic adhesion protein Slitrk2
Publication date: Available online 8 January 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Connor Loomis, Aliyah Stephens, Remi Janicot, Usman Baqai, Laura Drebushenko, Jennifer RoundAbstractSynaptic adhesion proteins play a critical role in the formation and maintenance of synapses in the developing nervous system. Errors in synaptic adhesion constitute the molecular basis of many neuropsychiatric disorders, including schizophrenia, bipolar disorder, Tourette syndrome, and autism. Slit- and Trk-like proteins (Slitrks) are a family of leucine-rich repeat containing transmembrane proteins that promote synaptogen...
Source: Molecular and Cellular Neuroscience - January 8, 2020 Category: Neuroscience Source Type: research

Δ9-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons
Publication date: Available online 7 January 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Carole Shum, Lucia Dutan, Emily Annuario, Katherine Warre-Cornish, Samuel E. Taylor, Ruth D. Taylor, Laura C. Andreae, Noel J. Buckley, Jack Price, Sagnik Bhattacharyya, Deepak P. SrivastavaAbstractEndocannabinoids regulate different aspects of neurodevelopment. In utero exposure to the exogenous psychoactive cannabinoid Δ9-tetrahydrocannabinol (Δ9-THC), has been linked with abnormal cortical development in animal models. However, much less is known about the actions of endocannabinoids in human neurons. Here we investi...
Source: Molecular and Cellular Neuroscience - January 7, 2020 Category: Neuroscience Source Type: research

Deficits in developmental neurogenesis and dendritic spine maturation in mice lacking the serine protease inhibitor neuroserpin
Publication date: Available online 2 December 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Melanie Hermann, Rebecca Reumann, Katrin Schostak, Dilara Kement, Mathias Gelderblom, Christian Bernreuther, Renato Frischknecht, Angela Schipanski, Sergej Marik, Susanne Krasemann, Diego Sepulveda-Falla, Michaela Schweizer, Tim Magnus, Markus Glatzel, Giovanna GalliciottiAbstractNeuroserpin is a serine protease inhibitor of the nervous system required for normal synaptic plasticity and regulating cognitive, emotional and social behavior in mice. The high expression level of neuroserpin detected at late stages of nervous...
Source: Molecular and Cellular Neuroscience - December 2, 2019 Category: Neuroscience Source Type: research

Macrophage migration inhibitory factor and its binding partner HTRA1 are expressed by olfactory ensheathing cells
Publication date: Available online 30 November 2019Source: Molecular and Cellular NeuroscienceAuthor(s): A.A. Wright, M. Todorovic, M. Murtaza, J.A. St John, J.A. EkbergAbstractMacrophage migration inhibitory factor (MIF) is an important regulator of innate immunity with key roles in neural regeneration and responses to pathogens, amongst a multitude of other functions. The expression of MIF and its binding partners has been characterised throughout the nervous system, with one key exception: the primary olfactory nervous system. Here, we showed in young mice (postnatal day 10) that MIF is expressed in the olfactory nerve ...
Source: Molecular and Cellular Neuroscience - December 1, 2019 Category: Neuroscience Source Type: research

Cerebrospinal fluid and serum glycosphingolipid biomarkers in canine globoid cell leukodystrophy (Krabbe Disease)
This study identified several biomarkers which may be useful in the development of therapeutics for GLD. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - December 1, 2019 Category: Neuroscience Source Type: research

SNAP-25 phosphorylation at Ser187 is not involved in Ca2+ or phorbolester-dependent potentiation of synaptic release
In conclusion, our results indicate that phosphorylation of Ser-187 in SNAP-25 is not involved in modulation of synaptic release by Ca2+ or phorbol esters. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - December 1, 2019 Category: Neuroscience Source Type: research

Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses
Publication date: Available online 23 November 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Jennifer J. O'Brien, James P. O'Callaghan, Diane B. Miller, Suman Chalgeri, Lawrence P. Wennogle, Robert E. Davis, Gretchen L. Snyder, Joseph P. HendrickAbstractA novel, potent, and highly specific inhibitor of calcium-calmodulin-dependent phosphodiesterases (PDE) of the PDE1 family, ITI-214, was used to investigate the role of PDE1 in inflammatory responses. ITI-214 dose-dependently suppressed lipopolysaccharide (LPS)-induced gene expression of pro-inflammatory cytokines in an immortalized murine microglial cell line, ...
Source: Molecular and Cellular Neuroscience - November 25, 2019 Category: Neuroscience Source Type: research