Molecular and Cellular Neuroscience 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Urate mitigates oxidative stress and motor neuron toxicity of astrocytes derived from ALS-linked SOD1G93A mutant mice
Publication date: October 2018Source: Molecular and Cellular Neuroscience, Volume 92Author(s): Rachit Bakshi, Yuehang Xu, Kaly A. Mueller, Xiqun Chen, Eric Granucci, Sabrina Paganoni, Ghazaleh Sadri-Vakili, Michael A. SchwarzschildAbstractDominant mutations in an antioxidant enzyme superoxide dismutase-1 (SOD1) cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease characterized by loss of motor neurons. Oxidative stress has also been linked to many of the neurodegenerative diseases and is likely a central mechanism of motor neuron death in ALS. Astrocytes derived from mutant SOD1G93A mouse mod...
Source: Molecular and Cellular Neuroscience - July 10, 2018 Category: Neuroscience Source Type: research
Identification and characterization of two novel alternatively spliced E2F1 transcripts in the rat CNS
Publication date: October 2018Source: Molecular and Cellular Neuroscience, Volume 92Author(s): Dan P. Jackson, Jenhao H. Ting, Paul D. Pozniak, Claire Meurice, Stephanie S. Schleidt, Anh Dao, Amy H. Lee, Eva Klinman, Kelly L. Jordan-SciuttoAbstractE2F1 is a transcription factor classically known to regulate G0/G1 to S phase progression in the cell cycle. In addition, E2F1 also regulates a wide range of apoptotic genes and thus has been well studied in the context of neuronal death and neurodegenerative diseases. However, its function and regulation in the mature central nervous system are not well understood. Alternative s...
Source: Molecular and Cellular Neuroscience - July 10, 2018 Category: Neuroscience Source Type: research
Partial loss of ATP13A2 causes selective gliosis independent of robust lipofuscinosis
This study suggests that heterozygous loss-of-function mutations in ATP13A2 are likely harmful and indicates that glial involvement in the disease process may be an early event that positions the CNS for subsequent disease development. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - July 10, 2018 Category: Neuroscience Source Type: research
Semaphorin 3A as an inhibitive factor for migration of olfactory ensheathing cells through cofilin activation is involved in formation of olfactory nerve layer
Publication date: October 2018Source: Molecular and Cellular Neuroscience, Volume 92Author(s): Ying Wang, Xiaomei Bao, Shiyang Wu, Xiya Shen, Fan Zhang, Zhaoting Lv, Qian Wu, Changnan Xie, Huitao Liu, Jian Lin, Honglin Teng, Zhihui HuangAbstractOlfactory ensheathing cells (OECs) migrate from olfactory epithelium towards olfactory bulb (OB), contributing to formation of the presumptive olfactory nerve layer during development. However, it remains unclear that molecular mechanism of regulation of OEC migration in OB. In the present study, we found that OECs highly expressed the receptors of semaphorin 3A (Sema3A) in vitro an...
Source: Molecular and Cellular Neuroscience - July 10, 2018 Category: Neuroscience Source Type: research
Regulation of actin dynamics during structural plasticity of dendritic spines: Signaling messengers and actin-binding proteins
Publication date: Available online 9 July 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Jelena Borovac, Miquel Bosch, Kenichi OkamotoAbstractActivity-dependent plasticity of synaptic structure and function plays an essential role in neuronal development and in cognitive functions including learning and memory. The formation, maintenance and modulation of dendritic spines are mainly controlled by the dynamics of actin filaments (F-actin) through interaction with various actin-binding proteins (ABPs) and postsynaptic signaling messengers. Induction of long-term potentiation (LTP) triggers a cascade of events invo...
Source: Molecular and Cellular Neuroscience - July 10, 2018 Category: Neuroscience Source Type: research
Regulation of AMPA receptor trafficking and exit from the endoplasmic reticulum
Publication date: Available online 12 March 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Joseph E. Pick, Edward B. ZiffAbstractA fundamental property of the brain is its ability to modify its function in response to its own activity. This ability for self-modification depends to a large extent on synaptic plasticity. It is now appreciated that for excitatory synapses, a significant part of synaptic plasticity depends upon changes in the post synaptic response to glutamate released from nerve terminals. Modification of the post synaptic response depends, in turn, on changes in the abundances of AMPA receptors i...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
Microtubules and axon regeneration in C. elegans
Publication date: Available online 16 March 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Lizhen ChenAbstractAxon regeneration is a fundamental and conserved process that allows the nervous system to repair circuits after trauma. Due to its conserved genome, transparent body, and relatively simple neuroanatomy, C. elegans has become a powerful model organism for studying the cellular and molecular mechanisms underlying axon regeneration. Various studies from different model organisms have found microtubule dynamics to be pivotal to axon regrowth. In this review, we will discuss the latest findings on how microt...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders
Publication date: Available online 24 March 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Murat Kilinc, Thomas Creson, Camilo Rojas, Massimiliano Aceti, Jacob Ellegood, Thomas Vaissiere, Jason P. Lerch, Gavin RumbaughAbstractSYNGAP1 loss-of-function variants are causally associated with intellectual disability, severe epilepsy, autism spectrum disorder and schizophrenia. While there are hundreds of genetic risk factors for neurodevelopmental disorders (NDDs), this gene is somewhat unique because of the frequency and penetrance of loss-of-function variants found in patients combined with the range of brain disor...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
Mechanisms of neurotrophin trafficking via Trk receptors
Publication date: Available online 27 March 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Emily Scott-Solomon, Rejji KuruvillaAbstractIn neurons, long-distance communication between axon terminals and cell bodies is a critical determinant in establishing and maintaining neural circuits. Neurotrophins are soluble factors secreted by post-synaptic target tissues that retrogradely control axon and dendrite growth, survival, and synaptogenesis of innervating neurons. Neurotrophins bind Trk receptor tyrosine kinases in axon terminals to promote endocytosis of ligand-bound phosphorylated receptors into signaling endo...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
Metabotropic glutamate receptor trafficking
Publication date: Available online 29 March 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Young Ho Suh, Kai Chang, Katherine W. RocheAbstractThe metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that bind to the excitatory neurotransmitter glutamate and are important in the modulation of neuronal excitability, synaptic transmission, and plasticity in the central nervous system. Trafficking of mGlu receptors in and out of the synaptic plasma membrane is a fundamental mechanism modulating excitatory synaptic function through regulation of receptor abundance, desensitization, and si...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
Tetraspanins shape the synapse
Publication date: Available online 6 April 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Luca Murru, Edoardo Moretto, Giuseppe Martano, Maria PassafaroAbstractTetraspanins are a family of proteins largely expressed in mammals. These proteins share very similar structures and are involved in several biological processes spanning from the immune system to cancer growth regulation. Moreover, tetraspanins are scaffold proteins that are able to interact with each other and with a subset of proteins involved in the regulation of the central nervous system, including synapse formation, function and plasticity.In this ...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
Trafficking mechanisms of synaptogenic cell adhesion molecules
Publication date: Available online 6 April 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Luís F. Ribeiro, Ben Verpoort, Joris de WitAbstractNearly every aspect of neuronal function, from wiring to information processing, critically depends on the highly polarized architecture of neurons. Establishing and maintaining the distinct molecular composition of axonal and dendritic compartments requires precise control over the trafficking of the proteins that make up these cellular domains. Synaptic cell adhesion molecules (CAMs), membrane proteins with a critical role in the formation, differentiation and plasticity...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
New approaches for solving old problems in neuronal protein trafficking
Publication date: Available online 10 April 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Ashley M. Bourke, Aaron B. Bowen, Matthew J. KennedyAbstractFundamental cellular properties are determined by the repertoire and abundance of proteins displayed on the cell surface. As such, the trafficking mechanisms for establishing and maintaining the surface proteome must be tightly regulated for cells to respond appropriately to extracellular cues, yet plastic enough to adapt to ever-changing environments. Not only are the identity and abundance of surface proteins critical, but in many cases, their regulated spatial ...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
Dynamics, nanoscale organization, and function of synaptic adhesion molecules
Publication date: Available online 17 April 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Ingrid Chamma, Olivier ThoumineAbstractSynaptic adhesion molecules not only provide a physical link between pre- and post-synaptic membranes, but also contribute to synaptic differentiation and plasticity by organizing functional elements, in particular neurotransmitter receptors. The wealth of existing adhesive protein families including many isoforms and splice variants, calls for systematic identification of the levels and exchange rates of each of those protein members at specific synapse types. Complementary to electr...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
Ankyrins: Roles in synaptic biology and pathology
Publication date: Available online 3 May 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Katharine R. Smith, Peter PenzesAbstractAnkyrins are broadly expressed adaptors that organize diverse membrane proteins into specialized domains and link them to the sub-membranous cytoskeleton. In neurons, ankyrins are known to have essential roles in organizing the axon initial segment and nodes of Ranvier. However, recent studies have revealed novel functions for ankyrins at synapses, where they organize and stabilize neurotransmitter receptors, modulate dendritic spine morphology and control adhesion to the presynaptic si...
Source: Molecular and Cellular Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
