Molecular and Cellular Neuroscience Molecular and Cellular Neuroscience RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Norepinephrine control of ventromedial hypothalamic nucleus glucoregulatory neurotransmitter expression in the female rat: Role of monocarboxylate transporter function
Publication date: Available online 17 January 2019Source: Molecular and Cellular NeuroscienceAuthor(s): A.S.M. Hasan Mahmood, Santosh K. Mandal, Khaggeswar Bheemanapally, Mostafa M.H. Ibrahim, K.P. BriskiAbstractThe ventromedial hypothalamic nucleus (VMN) is a critical component of the neural circuitry that regulates glucostasis. Astrocyte glycogen is a vital reserve of glucose and its oxidizable metabolite L-lactate. In hypoglycemic female rats, estradiol-dependent augmentation of VMN glycogen phosphorylase (GP) protein requires hindbrain catecholamine input. The research here investigated the premise that norepinephrine ...
Source: Molecular and Cellular Neuroscience - January 18, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: January 2019Source: Molecular and Cellular Neuroscience, Volume 94Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - January 7, 2019 Category: Neuroscience Source Type: research

Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice
This study suggests that the RSG of aged mice is in an abnormal activated state. RSG function abnormality may be part of the cognitive decline mechanism. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - January 3, 2019 Category: Neuroscience Source Type: research

siRNA-mediated knockdown of B3GALT4 decreases GM1 ganglioside expression and enhances vulnerability for neurodegeneration
Publication date: Available online 3 January 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Megha Verma, Jay S. SchneiderAbstractReduced levels of brain gangliosides GD1a, GD1b, GT1b and to a lesser extent GM1 have been found in substantia nigra (SN) from Parkinson's disease (PD) patients, along with decreased gene expression for key enzymes (B3Galt4, St3gal2) involved in synthesis of these gangliosides. Based on these observations, the present study examined the extent to which decreased expression of B3GALT4 mRNA and resulting decreased levels of GM1 ganglioside in dopaminergic cells may increase the vulnerabi...
Source: Molecular and Cellular Neuroscience - January 3, 2019 Category: Neuroscience Source Type: research

Ouabain activates transcription factor EB and exerts neuroprotection in models of Alzheimer's disease
Publication date: Available online 28 December 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Ha-Lim Song, Atanas Vladimirov Demirev, Na-Young Kim, Dong-Hou Kim, Seung-Yong YoonAbstractThe number of neurofibrillary tangles containing abnormal hyperphosphorylated tau protein correlates with the degree of dementia in Alzheimer's disease (AD). In addition, autophagosome accumulation and disturbance of autophagy, the process by which toxic aggregate proteins are degraded in the cytosol, are also found in AD models. These indicate that regulation of the autophagy-lysosome system may be a potential therapeutic target ...
Source: Molecular and Cellular Neuroscience - December 28, 2018 Category: Neuroscience Source Type: research

Impairment of chaperone-mediated autophagy affects neuronal homeostasis through altered expression of DJ-1 and CRMP-2 proteins
In this study, we have manipulated CMA function through alterations of LAMP2A abundance of utilizing primary rat cortical neurons, to identify potential changes to the neuronal proteome occurring prior to actual toxic effects. We have identified a list of proteins with significant,>2-fold change in abundance following our manipulations, of which PARK7/DJ-1 – an anti-oxidant implicated in hereditary forms of Parkinson's Disease (PD), and DPYSL2/CRMP-2 – a microtubule-binding phosphoprotein involved in schizophrenia pathogenesis – were both found to have measurable effects on neuronal homeostasis and phenotype. Taken t...
Source: Molecular and Cellular Neuroscience - December 15, 2018 Category: Neuroscience Source Type: research

Cerebrospinal fluid biomarker for Parkinson's disease: An overview
In conclusion, technical advancements in the field already yielded promising results, but further multicenter trials with well-defined cohorts, standardized protocols and integrated data analysis of different modalities are needed before successful translation into routine clinical application. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - December 10, 2018 Category: Neuroscience Source Type: research

Fluid and PET biomarkers for amyloid pathology in Alzheimer's disease
Publication date: Available online 8 December 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Ann D. Cohen, Susan M. Landau, Beth E. Snitz, William E. Klunk, Kaj Blennow, Henrik ZetterbergAbstractAlzheimer's disease (AD) is characterized by amyloid plaques and tau pathology (neurofibrillary tangles and neuropil threads). Amyloid plaques are primarily composed of aggregated and oligomeric β-amyloid (Aβ) peptides ending at position 42 (Aβ42). The development of fluid and PET biomarkers for Alzheimer's disease (AD), has allowed for detection of Aβ pathology in vivo and marks a major advancement in understanding ...
Source: Molecular and Cellular Neuroscience - December 8, 2018 Category: Neuroscience Source Type: research

Biomarkers for tau pathology
Publication date: Available online 7 December 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Michael Schöll, Anne Maass, Niklas Mattsson, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, William JagustAbstractThe aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-associated tau protein characterizes 80% of all dementia disorders, the most common neurodegenerative disorders. These so-called tauopathies are hitherto not curable and their diagnosis, especially at early disease stages, has traditionally proven difficult. A keystone in the diagnosis of tauopathies was the developmen...
Source: Molecular and Cellular Neuroscience - December 7, 2018 Category: Neuroscience Source Type: research

Melanocortin 4 receptor activation protects striatal neurons and glial cells from 3-nitropropionic acid toxicity
Publication date: Available online 4 December 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Julieta Saba, Lila Carniglia, Delia Ramírez, Juan Turati, Mercedes Imsen, Daniela Durand, Mercedes Lasaga, Carla CarusoAbstractα-Melanocyte stimulating hormone (α-MSH) is a melanocortin which exerts potent anti-inflammatory and anti-apoptotic effects. Melanocortin 4 receptors (MC4R) are abundantly expressed in the brain and we previously demonstrated that [Nle(4), D-Phe(7)]melanocyte-stimulating hormone (NDP-MSH), an α-MSH analogue, increased expression of brain derived-neurotrophic factor (BDNF), and peroxisome prol...
Source: Molecular and Cellular Neuroscience - December 5, 2018 Category: Neuroscience Source Type: research

Review: Fluid biomarkers in the human prion diseases
Publication date: Available online 4 December 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Andrew G.B. Thompson, Simon H. MeadAbstractThe human prion diseases are a diverse set of often rapidly progressive neurodegenerative conditions associated with abnormal forms of the prion protein. We review work to establish diagnostic biomarkers and assays that might fill other important roles, particularly those that could assist the planning and interpretation of clinical trials. The field now benefits from highly sensitive and specific diagnostic biomarkers using cerebrospinal fluid: detecting by-products of rapid ne...
Source: Molecular and Cellular Neuroscience - December 5, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: December 2018Source: Molecular and Cellular Neuroscience, Volume 93Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - November 17, 2018 Category: Neuroscience Source Type: research

Cyclo(His-Pro) inhibits NLRP3 inflammasome cascade in ALS microglial cells
In this study we used hSOD1(G93A) microglial cells to investigate the effects of the antioxidant and anti-inflammatory cyclic dipeptide (His-Pro) on LPS-induced inflammasome activation. We found that cyclo(His-Pro) inhibits NLRP3 inflammasome activation by reducing protein nitration via reduction in NO and ROS levels, indicative of lower peroxynitrite generation by LPS. Low levels in peroxynitrite are related to NF-κB inhibition responsible for iNOS down-regulation and NO dampening. On the other hand, cyclo(His-Pro)-mediated ROS attenuation, not linked to Nrf2 activation in this cellular model, is ascribed to increased so...
Source: Molecular and Cellular Neuroscience - November 14, 2018 Category: Neuroscience Source Type: research

Interaction of nectin-2α with the auxiliary protein of the voltage-gated A-type K+ channel Kv4.2 dipeptidyl aminopeptidase-like protein at the boundary between the adjacent somata of clustered cholinergic neurons in the medial habenula
Publication date: Available online 5 November 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Hajime Shiotani, Muneaki Miyata, Kiyohito Mizutani, Shujie Wang, Akira Mizoguchi, Hideki Mochizuki, Kenji Mandai, Yoshimi TakaiAbstractThe medial habenula (MHb) receives septal inputs and sends efferents to the interpeduncular nucleus and is implicated in stress, depression, memory, and nicotine withdrawal syndrome. We previously showed by immunofluorescence microscopy that the cell adhesion molecule nectin-2α is expressed in the cholinergic neurons in the developing and adult mouse MHbs and localized at the boundary be...
Source: Molecular and Cellular Neuroscience - November 6, 2018 Category: Neuroscience Source Type: research

Biomarkers for diseases with TDP-43 pathology
Publication date: Available online 3 November 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Petra Steinacker, Peggy Barschke, Markus OttoAbstractThe discovery that aggregated transactive response DNA-binding protein 43 kDa (TDP-43) is the major component of pathological ubiquitinated inclusions in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) caused seminal progress in the unveiling of the genetic bases and molecular characteristics of these now so-called TDP-43 proteinopathies. Substantial increase in the knowledge of clinic-pathological coherencies, especially for FTLD var...
Source: Molecular and Cellular Neuroscience - November 4, 2018 Category: Neuroscience Source Type: research