Lifestyle changes in the management of adulthood and childhood obesity.
Authors: Orio F, Tafuri D, Ascione A, Marciano F, Savastano S, Colarieti G, Orio M, Colao A, Palomba S, Muscogiuri G
Abstract
Adulthood and childhood obesity is rapidly becoming an epidemic problem and it has a short and long-term impact on health. Short-term consequences are mostly represented by psychological effects; in fact obese children have more chances to develop psychological or psychiatric problems than non-obese children. The main long-term effect is represented by the fact that childhood obesity continues into adulthood obesity and this results in negative effects in young adult life, since obe...
Source: Minerva Endocrinologica - September 9, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Pressure pain threshold and Beta-endorphins plasma level are higher in lean polycystic ovary syndrome women.
CONCLUSIONS: β- endorphin serum level as well as PPT are higher in lean PCOS group than in controls. We found correlations between β- endorphin levels and PPT in the PCOS group. It may suggest the role of endogenous opioids in the pathogenesis of PCOS and also that the increases in circulating plasma Beta-endorphins concentration can increases PPT in this group.
PMID: 27603705 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 9, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Micro-carcinoma: only a diagnostic epidemic?
CONCLUSION: Micro-carcinoma is a more represented entity than apparently suspected. Now a days, cytology is the most precise diagnostic support to the therapeutic management of thyroid node, yet it is still charged with false negatives. The evaluation of data records combined with some molecular biology techniques and applied to cytology, could help in giving more appropriate surgical indication, allowing the surgery to be therapeutic more than diagnostic.
PMID: 27589679 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 3, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Fibroblast growth factors: new insights, new targets in the management of diabetes.
Authors: Kyrou I, Weickert MO, Gharanei S, Randeva HS, Tan BK
Abstract
The fibroblast growth factor (FGF) family consists of 22 evolutionarily and structurally related proteins (FGF1 to FGF23; with FGF15 being the rodent ortholog of human FGF19). Based on their mechanism of action, FGFs can be categorized into intracrine, autocrine/paracrine and endocrine subgroups. Both autocrine/paracrine and endocrine FGFs are secreted from their cells of origin and exert their effects on target cells by binding to and activating specific single-pass transmembrane tyrosine kinase receptors (FGFRs). Moreover, FGF binding...
Source: Minerva Endocrinologica - July 16, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Novel perspectives on hypothalamic-pituitary dysfunction as a risk factor for nonalcoholic fatty liver disease.
CONCLUSIONS: Hormonal substitution of endocrine deficiencies has been shown to have beneficial effects at least in some instances. While the association between type 2 diabetes and NAFLD is well known, there is rather limited appreciation of the condition among common endocrine diseases involving hypothalamic-pituitary axes. In diseases involving hypothalamic-pituitary areas and manifesting clinically with endocrine deficiencies of hypothalamic-pituitary axes such as childhood- onset craniopharyngioma NAFLD is a frequent sequela of hypothalmic obesity.
PMID: 27405476 [PubMed - as supplied by publisher] (Source: Min...
Source: Minerva Endocrinologica - July 15, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Management of Pituitary Disease.
Authors: Shimon I
PMID: 27381738 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 7, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
The possible impact of Advanced Glycation End products on pregnancy outcome in women with Diabetes Mellitus type 1.
Authors: Pertynska-Marczewska M, Cypryk K
Abstract
Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism in which glucose is underutilized, resulting in hyperglycemia. Reproductive impairment in poorly controlled T1DM results from a combined effect of insulin deficiency and hyperglycemia that disrupt the functioning of metabolic signals participating in the regulation of the reproductive system. Good metabolic control as a result of intensive insulin therapy has a great impact on the fertility and childbearing possibilities in the T1DM females. Advanced glycation end products ...
Source: Minerva Endocrinologica - June 16, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Is retesting in growth hormone deficient children really useful?
CONCLUSIONS: The majority of patients idiopathic GHD proved to be transient. IGF-I levels alone do not discriminate subjects with persistent from those with transient GHD. Therefore, after the end of GH substitutive treatment, a re-evaluation of GH secretion is mandatory to verify the persistence of GHD in adulthood.
PMID: 27304071 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - June 16, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Endoscopic imaging in the management of gastroenteropancreatic neuroendocrine tumors: update for endocrinologists.
Authors: Pellicano R, Fagoonee S, Altruda F, Bruno M, Saracco GM, DE Angelis C
Abstract
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors deriving from the gastrointestinal (GI) neuroendocrine system. Since these neoplasms are usually very small, located deeply within the retroperitoneum or into an extramucosal site of the GI tract and, lastly, because they may be multi-sited, radiological imaging modalities, in combination with endoscopy, are the diagnostic workhorses in patients with GEP-NETs. Endoscopic approach is useful for detection, bioptic diagnosis and cur...
Source: Minerva Endocrinologica - June 16, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Bariatric surgery as an option for diabetes mellitus prevention and treatment in obese persons.
Authors: Ugale S, Agarwal D, Satwalekar V, Rao N, Ugale A
Abstract
Bariatric surgery has been found to be very useful in treating established type-2 diabetes in obese persons, as well as in borderline diabetics, besides giving a good weight loss. Various modifications of the primary bariatric procedures have been introduced, with differing advantages and better efficacy. Good incretin responses from the distal gut give the best results and combining medical treatment are helping patients to get very good glycemic control over a longer term.
PMID: 27270500 [PubMed - as supplied by publisher] (Source...
Source: Minerva Endocrinologica - June 10, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Congenital GnRH deficiency: a complex and genetically heterogeneous disease affecting human fertility and sexual development.
Authors: Bonomi M, Quinton R
PMID: 27213783 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 25, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Congenital hypogonadotropic hypogonadism: implications of absent mini-puberty.
This article will review our current understanding of the mechanisms and clinical consequences of mini-puberty. Furthermore, evidence for the optimal clinical management of patients with absent mini-puberty will be discussed.
PMID: 27213784 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 25, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Diabetes mellitus and heart failure: a review of the use of antidiabetic medications in patients with heart failure.
Authors: Samia El Hayek MM, Beydoun MF, Azar S
Abstract
Diabetes mellitus increases the mortality secondary to heart failure independent of hypertension and coronary artery disease. Several hypoglycemic agents are used to achieve glycemic control, of which several classes however still raise controversies in terms of safety in patients with concomitant heart failure: Metformin does not carry an increased risk of exacerbation in patients with stable heart failure, yet should be avoided in patients with unstable disease or chronic kidney disease. Sulfonylureas are neither associated with an increased mortali...
Source: Minerva Endocrinologica - May 20, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Hypogonadotropic hypogonadism and metabolic syndrome: insights from the high-fat diet experimental rabbit animal model.
Authors: Morelli A, Vignozzi L, Maggi M
Abstract
The aetiology of metabolic syndrome (MetS) is complex and involves the interplay between environmental, lifestyle and genetic determinants. MetS in men can be associated with a biochemical pattern of partial hypogonadotropic hypogonadism (HH). A similar pattern has been noted in both men and women with a variety of acute illnesses and chronic diseases, and there is ongoing debate regarding whether this phenomenon might adaptive (e.g. diverting resources from reproduction into survival), or maladaptive (e.g. anaemia, sarcopaenia, osteopaenia and fatigue of an...
Source: Minerva Endocrinologica - April 8, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Neuroradiological findings in hypogonadotropic hypogonadism.
Authors: Salvalaggio A, Elefante A, Manara R
Abstract
Hypogonadotropic hypogonadism (HH) is a clinical hallmark of a heterogeneous group of acquired and inherited diseases. Patients with HH undergo brain imaging in order to investigate morphological or signal abnormalities at the level of the hypothalamic-pituitary structures. The presence of tumors, lesions or atrophy might be the explanation of the hormone dysfunction. Nonetheless, in most patients both the hypothalamus and the pituitary gland appear normal. In some cases, the presence of ancillary, not necessarily HH-related brain abnormalities might pr...
Source: Minerva Endocrinologica - April 8, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
