Concomitant use of proton pump inhibitors and dual antiplatelet therapy for cardiovascular outcomes.
CONCLUSIONS: PPIs should be administered in patients on DAPT at risk for GI bleeding. However the uncertain benefit of PPIs in patients who are not at risk of GI bleeding and the unclear risk in MACE suggest that caution should be used when prescribing PPIs in these patients.
PMID: 27808485 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 5, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Novel acquisitions in the diagnosis of medullary thyroid carcinoma.
CONCLUSIONS: The measurement of calcitonin in FNA washout fluids is essential due to poor accuracy of conventional cytology to detect MTC. Genetic analysis can help to identify those advanced MTC with poorer prognosis who do not respond to chemotherapy. Procalcitonin may in the next future replace calcitonin as serum diagnostic marker of MTC. Recent evidence based data seem to suggest the emerging role of functional imaging in recurrent MTC in patients with calcitonin serum levels > 150 pg/ml.
PMID: 27808486 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 5, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Insulin treatment may not be associated with worse prognosis in acute heart failure diabetic patients.
CONCLUSIONS: Insulin-treated diabetic patients with HF and HbA1c-matched patients treated with OAD have similarly ominous prognosis. Ours results favor insulin as a marker of poor health condition.
PMID: 27792213 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 30, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Prevalence, etiology and management of nonalcoholic fatty liver disease in patients with polycystic ovary syndrome.
Authors: Makri E, Tziomalos K
Abstract
Obesity and insulin resistance (IR) are frequently present in patients with polycystic ovary syndrome (PCOS). Both disorders also play an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Accordingly, NAFLD is frequently present in patients with PCOS. In the present review, we summarize the findings of the major studies that assessed the prevalence of NAFLD in patients with PCOS. The factors driving the increased frequency of NAFLD in patients with PCOS are also analyzed. Finally, we discuss the management options of NAFLD in patients wit...
Source: Minerva Endocrinologica - October 30, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
An up-todate on the methabolic syndrome's epigenomic risk.
Authors: Perricone R, Pizzuti A
Abstract
The primitive genome's and the individual phenotype's modifications by epygenesys surveyes are crucial to evaluate the methabolic syndrome risk and its prevention. Through the most recent surveys, this analysis is aimed to several processes by which the various epigenetic types who are different from one to another subject may act on the methabolism key-genes, like that they even indirectly arouse the straight onset of one or more methabolic syndromes: the risk of passing this syndrome to next offsprings is more or less high. Through the new later surveyes who are o...
Source: Minerva Endocrinologica - October 30, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Endocrine and metabolic disorders interplaying with nonalcoholic fatty liver disease.
Authors: Polyzos SA
PMID: 27792216 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 30, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Adipose tissue, obesity and nonalcoholic fatty liver disease.
Authors: Polyzos SA, Kountouras J, Mantzoros CS
Abstract
The association of obesity with nonalcoholic fatty liver disease (NAFLD) has been established. Obesity has been linked not only to initial stages of the disease, i.e., simple steatosis (SS), but also to its severity. Form an epidemiologic point of view, both diseases has an increasing prevalence worldwide. From a pathogenetic point of view, obesity and its associate IR contribute to the initial fat accumulation in the hepatocyte (SS), but also to the progression of SS to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis and hepatocellular c...
Source: Minerva Endocrinologica - October 11, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Difficult management in parathyroid carcinoma with synchronous parathyroid hyperplasia.
Authors: Pagni F, Casella G, Bosisio FM, Costantini M, Fioretta G, Nicoletti G, Baldini V, Di Bella C
PMID: 27677089 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 28, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Antenatal oral glucose tolerance test in women with gestational diabetes mellitus: fasting plasma glucose is the best predictor of both large for-gestational-age newborns and postpartum glucose tolerance.
CONCLUSIONS: In women with gestational diabetes mellitus, FPG on the diagnostic OGTT was the glycemic value that best predicted both LGA and after delivery AGT.
PMID: 27652599 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 24, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Ruminant trans-fatty acids and risk of breast cancer: a systematic review and meta-analysis of observational studies.
CONCLUSIONS: No association was found between c9,t11-CLA intake and breast cancer risk, but the number of studies identified was small.
PMID: 27627219 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 18, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Diabetes mellitus and cardiovascular disease: strategies for prevention.
Authors: Grineva E
PMID: 27600640 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 9, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Fasting glycemia at the first prenatal visit and pregnancy outcomes in Russian women.
CONCLUSIONS: Only the highest glucose category (5.6<FG<7 mmol/L) at the first prenatal visit was strongly associated with some adverse pregnancy outcomes.
PMID: 27600641 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 9, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Type II diabetes patients with proteinuria and the recovery of their metabolic parameters.
CONCLUSIONS: The use of antihypertensive drugs is not standardized, and only a small portion of patients were treated with ACEI or ARB drugs. Therefore, the proteinuria in diabetic patients should be timely screened and evaluated, as well as renal and metabolic function and antihypertensives and lipid-lowering drugs rationally used.
PMID: 27600642 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 9, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Endoscopic imaging in the management of gastroenteropancreatic neuroendocrine tumors.
Authors: Pellicano R, Fagoonee S, Altruda F, Bruno M, Saracco GM, De Angelis C
Abstract
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors deriving from the gastrointestinal (GI) neuroendocrine system. Since these neoplasms are usually very small, located deeply within the retroperitoneum or into an extramucosal site of the GI tract and, lastly, because they may be multi-sited, radiological imaging modalities, in combination with endoscopy, are the diagnostic workhorses in patients with GEP-NETs. Endoscopic approach is useful for detection, bioptic diagnosis and cur...
Source: Minerva Endocrinologica - September 9, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Obesity: single house for many evils.
Authors: Kumar A, Nayak BP, Kumar A
Abstract
World Health Organization (WHO) considers obesity as one of the fastest growing metabolic disorders other than diabetes. It is a complex interplay of lifestyle and associated genes. Obesity has been considered as a disease with multiple targets and very often compared in this sense with its sibling disease type 2 diabetes. The disease is pathology of the adipocytes and develops as a result of hypertrophy and hyperplasia of these cells, former being the major concern but its effects could be seen on various organs in the form of cardio-vascular disease, stroke, c...
Source: Minerva Endocrinologica - September 9, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
