Clinical and molecular prognostic factors in adrenocortical carcinomas.
CONCLUSIONS: Individualizing patients' prognosis and tumor biology appears as a necessary step for personalized medicine. In addition to tumor stage and tumor grade, the genomic classification may precise the risk stratification and thus help defining therapeutic strategy.
PMID: 30221891 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 18, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Adrenocortical tumours: challenges and recent advances in diagnosis and treatment.
Authors: Ronchi CL
PMID: 30221892 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 18, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Retrospective clinical analysis of glucose metabolism in acromegaly patients.
Authors: Zhou X, Gong Y, Tian J, Yang G, Li F, Li L, Ba J, Dou J, Mu Y
PMID: 30037183 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 26, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Clinical diagnosis of endocrine diseases.
Authors: Giovanella L
PMID: 29991210 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Obesity and breast cancer risk: implications of MiR-126.
Authors: Mormile R
PMID: 29991211 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Weight gain increase plasma levels of uric acid in adults in China.
Authors: Liu M, Zhang M, Chen X, Zhang X
PMID: 29991212 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Polycystic ovary syndrome and vitamin D serum levels.
Authors: Cetkovic N, Pellicano R, Bjelica A, Abenavoli L
PMID: 29991213 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Pathogenesis of benign unilateral adrenocortical tumours: focus on cAMP/PKA pathway.
Authors: Weigand I
Abstract
Somatic mutations affecting genes in the cAMP/PKA (Protein Kinase A) signaling pathway have been described as causative for the pathogenesis of benign unilateral adrenocortical adenomas associated with cortisol over secretion. These include predominantly somatic mutations in the PRKACA gene which encodes the catalytic subunit α of PKA. In addition, mutations in the GNAS gene, coding for the stimulatory G protein α, have been observed in approximately 10 % of cortisol producing adenomas (CPAs). The mutations render PKA signaling constitutively active and are therefore involved ...
Source: Minerva Endocrinologica - July 3, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
The role of Insulin-like Growth Factor (IGF) system in the adrenocortical tumors.
CONCLUSIONS: Nowadays, predictive markers for the response of target-IGF therapy are missing and further studies which investigate new molecular markers and evaluate the entire IGF receptors, including the IR, are urgently needed.
PMID: 29963827 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - July 3, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Autonomous hypercortisolism: definition and clinical implications.
Authors: Reimondo G, Puglisi S, Pia A, Terzolo M
Abstract
In current practice, an adrenal adenoma usually comes as an unexpected byproduct of an imaging study performed for unrelated reasons, without any prior suspect of adrenal disease. Therefore, these tumors currently represent a public health challenge because they are increasingly recognized due to the widespread use of high-resolution cross-sectional imaging for diagnostic purposes. In radiology series, the prevalence of adrenal adenomas increases steeply with age, from around 3% below the age of 50 years up to 10% in the ageing population. These tum...
Source: Minerva Endocrinologica - July 3, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
The role of steroid metabolome analysis for the diagnosis and follow-up of adrenocortical tumours.
Authors: Chortis V
Abstract
The diagnostic work up of adrenal tumours, often incidentally discovered, has emerged as an ever-increasing diagnostic problem for clinical endocrinologists. No imaging modality has sufficiently high sensitivity and specificity at differentiating benign from malignant adrenal lesions. It has long been observed that adrenocortical carcinomas (ACCs) present an immature pattern of steroidogenesis, dominated by steroid hormone precursors. Modern mass spectrometry-based assays can generate multi-steroid metabolite profiles in urine collections, which can detect differences between AC...
Source: Minerva Endocrinologica - June 16, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
The beta-cell death in long-term type 2 diabetes mellitus: never say never again.
Authors: Koufakis T, Ioannidis I, Zebekakis P, Kotsa K
PMID: 29808640 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 30, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
New targeted therapies for adrenocortical carcinomas.
Authors: Manso J, Pezzani R
Abstract
Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. It has been undergone to in-depth clinical and laboratory investigations, with the help of the most important research groups of all over the world. Nonetheless the cure for this kind of neoplasia is not right around the corner, given its complexity and multi-faceted feature, that lead researchers to think at "one person one ACC". Currently total resection is the most concrete option for ACC patients, whenever possible. Although years are still necessary for an effective treatment, indubitably the ...
Source: Minerva Endocrinologica - May 30, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Unilateral non-aldosterone producing adrenocortical tumors.
Authors: Morelli V, Palmieri S
Abstract
Adrenal incidentaloma is a frequent clinical finding. Once an adrenal mass is detected, is mandatory to determine whether the lesion is malignant or benign and whether it is hormonally active or non- functioning, to estabilish an adequate treatement or follow-up. The European Society and ENSAT Guidelines recently provided the best recommendation based on the available literature. However, due to the retrospective design of the majority of the studies, the small number of patients included and the inadequate follow-up, some issues are still unresolved. In particular, ...
Source: Minerva Endocrinologica - May 30, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Women with type 2 diabetes in pregnancy remain a high-risk group.
Authors: Mcgrath RT, Gunton JE, Hocking SL, Glastras SJ, Fulcher GR
PMID: 29761685 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - May 17, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
