Comparison the relationship between the levels of insulin resistance, hs-CRP, percentage of body fat and serum osteoprotegerin/receptor activator of nuclear factor κβ ligand in prediabetic patients.
CONCLUSIONS: Increased sRANKL and OPG levels were associated with prediabetic subjects. sRANKL and OPG may play a role in the pathogenesis of diabetes as well as metabolic disturbance.
PMID: 28146138 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - February 3, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Is cardiovascular risk in women with PCOS a real risk? Current insights.
Authors: Papadakis G, Kandaraki E, Papalou O, Vryonidou A, Diamanti-Kandarakis E
Abstract
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive aged women. PCOS incorporates not only symptoms related to the reproductive system but also a clustering of systemic metabolic abnormalities that are linked with increased risk for cardiovascular disease (CVD). More specifically, metabolic aberrations such as impaired glucose and lipid metabolism, accompanied by increased low-grade inflammation as well as elevated coagulation factors appear to contribute to the increased cardiovascu...
Source: Minerva Endocrinologica - February 3, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Tumor and normal thyroid spheroids: from tissues to zebrafish.
CONCLUSIONS: We report the characterization of multicellular spheroids obtained from PTCs and normal thyroid tissues, showing that they are enriched in stem-like cells. Moreover, we established xenografts of spheroids in zebrafish, demonstrating that they stimulate neoangiogenesis. This in vivo model could be considered as a valuable platform to test the effects of anticancer drugs.
PMID: 28146140 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - February 3, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Type 1 diabetes from adolescence to adulthood: is there a permanent need for nutrition education and reeducation?
CONCLUSIONS: The results suggest that questions regarding carbohydrate counting may predict glycaemic control. Patients diagnosed in childhood may be more knowledable in diabetes management, but their practical skill in matching insulin dose and carbohydrate content is poor. Both groups improved their knowledge in similar proportion with same educational programme.
PMID: 28146141 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - February 3, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Should serum calcitonin be routinely measured in patients presenting with thyroid nodule?
CONCLUSION: Because patients with a nodule are subjected to ultrasound scanning and biopsy when the nodule size is greater than 5 cm or when there is a modifying ultrasound or clinical characteristic, the consensus at the multidisciplinary conference on thyroids rather than universal calcitonin screening of all nodules is the better option in our judgement.
PMID: 28092147 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - January 17, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Effect of dapagliflozin administration on metabolic syndrome, insulin sensitivity, and insulin secretion.
CONCLUSIONS: Dapagliflozin decreased body weight, BMI, waist circumference, total cholesterol, triglycerides, AUC of insulin and total insulin secretion, with a remission of MetS in 58.3%.
PMID: 28001016 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 23, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Improvement of Bone Turnover Markers and Bone Mineral Density following treatment of Primary Aldosteronism.
CONCLUSIONS: Our findings support that bone loss and potential fracture risk among PA patients are likely a result of aldosterone-mediated secondary hyperparathyroidism. Patients with early PA may already exhibit increased bone turnover despite no significant changes in BMD.
PMID: 28001017 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 23, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Diabetes mellitus and non-alcoholic fatty liver disease: the thread of Ariadne.
Authors: Kosmidou M, Milionis H
Abstract
Non alcoholic fatty liver disease (NAFLD, the hepatic fat accumulation) and non alcoholic steatohepatitis (NASH, the aggressive form of liver steatosis plus inflammation and hepatocyte necrosis) are reaching epidemic dimensions in subjects with diabetes mellitus (DM). Taking into account that the incidence of DM increases worldwide, these entities rerpresent major health problems. There is accumulating evidence that diabetic subjects with NASH are at increased risk not only for cardiovascular disease compications but also for cirrhosis and hepatocellular cancer. On ...
Source: Minerva Endocrinologica - December 20, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Adrenal disorders and nonalcoholic fatty liver disease.
Authors: Papanastasiou L, Fountoulakis S, Vatalas IA
Abstract
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the developed world and its pathogenesis is complex and multifactorial. It is considered the hepatic manifestation of the metabolic syndrome and is the leading cause of hepatic cirrhosis. This review aims to present current knowledge on the involvement of the adrenal glands in the development of NAFLD. Clinical and animal studies have shown that excess glucocorticoids (GC) have been implicated in the pathogenesis of NAFLD. Patients with NAFLD seem to have a subtle chro...
Source: Minerva Endocrinologica - December 17, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Bone metabolism in non alcoholic fatty liver disease: vitamin D status and bone mineral density.
This study aimed to review current evidences supporting the association between bone metabolism including low BMD and serum vitamin D level in patients with NAFLD. Epidemiolocal studies indicating lower BMD and vitamin D in patients with NAFLD have been reviewed. The main pathophysiological mechanisms including association of insulin resistance, serum adiponectin, ghrelin, osteopontin, osteoprotegerin, and osteocalcin with NAFLD and low BMD have been briefly reviewed and summarized. Results of current clinical trials investigating the role of vitamin D supplementation for treatment of hepatic steatosis and non alcoholic st...
Source: Minerva Endocrinologica - December 17, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Differential efficacy of methylcobalamin and alpha-lipoic acid treatment on negative and positive symptoms of (type 2) diabetic peripheral neuropathy.
CONCLUSIONS: Due to differences in efficacy, MC or ALA should be chosen according to the symptoms of individual patients.
PMID: 27901334 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 3, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Intestinal hormones, gut microbiota and nonalcoholic fatty liver disease (NAFLD).
Authors: Koukias N, Buzzetti E, Tsochatzis EA
Abstract
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and has a complex pathophysiology with multiple pathways of development and progression implicated. Intestinal hormones regulate multiple biological functions and may play a role in the pathogenesis of non alcoholic fatty liver disease (NAFLD) by affecting food intake, body weight and insulin resistance. Bacterial products can affect the secretion of these hormones and thus have an effect on metabolism. Gut microbiota are normally involved in the intestinal...
Source: Minerva Endocrinologica - November 24, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Hypogonadism and non-alcoholic fatty liver disease.
Authors: Mintziori G, Poulakos P, Tsametis C, Goulis DG
Abstract
Non-alcoholic fatty liver disease (NAFLD) is more common in men than in women. Thus, it has been suggested that sex steroids do have a role in the development of NAFLD. The aim of the current paper is to illustrate the association between NAFLD and hypogonadism, by reviewing data derived from both human and animal studies. The prevalence of NAFLD is high in men with hypogonadism, including those with idiopathic hypogonadotropic hypogonadism (IHH), as well as in women in post- menopause, those under estrogen receptor antagonist treatment or wo...
Source: Minerva Endocrinologica - November 24, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Iron overload and nonalcoholic fatty liver disease.
Authors: Datz C, Müller E, Aigner E
Abstract
Approximately one third of patients with non-alcoholic fatty liver disease (NAFLD) show signs of disturbed iron homeostasis as indicated by elevated serum ferritin with normal or mildly elevated transferrin saturation. Mild hepatic iron deposition is the typical histological finding in these subjects and the term "dysmetabolic iron overload syndrome (DIOS)" is now used to describe this syndrome. From a clinical point of view, excess iron likely aggravates the natural course of NAFLD with regard to liver-related endpoints and extrahepatic disease complications a...
Source: Minerva Endocrinologica - November 13, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Hypertriglyceridemic waist in type 1 diabetes patients. Prevalence and related factors.
CONCLUSIONS: The hypertriglyceridemic waist in men with T1D is associated with an atherogenic lipid profile, hypertension, worse metabolic diabetes control, increased insulin resistance and a higher prevalence of hypogonadism.
PMID: 27824243 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 10, 2016 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
