Pycnogenol ®: supplementary management of symptomatic osteoarthritis with a patch. An observational registry study.
CONCLUSIONS: Pycnogenol® patch was effective in controlling mild to moderate pain and inflammations and its related symptoms in subjects with knee OA over a period of three weeks.
PMID: 30561176 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 20, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Cardioprotection by metformin in type 2 diabetes: what is the truth?
Authors: Mormile R
Abstract
PMID: 30561177 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 20, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Improving effect of vitamin D supplementation on obesity-related diabetes in rats.
CONCLUSIONS: These suggested the beneficial effects of vitamin D supplementation in obesity-related diabetes rat, which may through VDR, IRS-1/p-IRS-1, and GluT4 signaling activation.
PMID: 30531693 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Pathological markers of somatotroph pituitary neuroendocrine tumors (PitNET)s predicting the response to medical treatment.
In conclusion, the SSTR expression profile and morphological subtypes of the somatotroph tumor may help predict the response to medical treatment. Such pathological profiling could become a useful decision-making tool for clinicians in the context of a multidisciplinary approach, after surgery failure.
PMID: 30531694 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Precision medicine in the treatment of acromegaly.
Authors: Puig-Domingo M, Marazuela M
Abstract
Acromegaly is a chronic disorder usually diagnosed late in the disease evolution, leading to substantial morbidity and mortality related to this long period of undiagnosed state as well as the difficulty in achieving normalization of GH hypersecretion and controlling tumour mass. First generation somatostatin analogues (SSA) are accepted as the first-line medical therapy or as second-line therapy in patients undergoing unsuccessful surgery. However, because a high percentage of patients experience SSA treatment failure, the inclusion of biomarkers associated wi...
Source: Minerva Endocrinologica - December 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Silent somatotropinomas.
Authors: Lamas C, García-Martínez A, Cámara R, Fajardo-Montanana C, Viguera L, Aranda I
Abstract
Silent somatotroph pituitary neuroendocrine tumors (or silent growth hormone pituitary neuroendocrine tumors, SGH-PitNET) are neoplasias with positive immunostaining for growth hormone (GH), in patients with no signs and symptoms of acromegaly nor biochemical evidence of GH hypersecretion. From a clinical stand-point they are considered and managed as non-functioning pituitary tumors, since they usually come to evidence due to mass-effects (headache, visual impairment, hypopituitarism) or as asymptomatic pit...
Source: Minerva Endocrinologica - December 13, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Monitoring of treament adherence with easypodTM in 6 Italian centres: a real-world experience.
CONCLUSIONS: EasypodTM seems to be a valid tool for quickly identifying non-adherence habits, allowing physicians to implement actions focused on reinforcing the importance of treatment both for patients and caregivers.
PMID: 30482007 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 1, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Bone health among patients with primary aldosteronism: a systematic review and meta-analysis.
CONCLUSIONS: PA is associated with hypercalciuria with subsequent secondary hyperparathyroidism. This potentially affects bone health. We recommend this to be part of complication screening among patients with PA.
PMID: 30482008 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 1, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Heterogeneous clinical features of ketosis-prone type 2 diabetes mellitus patients: gender, age, loss of weight and HbA1c.
CONCLUSIONS: Ketosis-prone T2DM patients are characterized by lower age at onset, higher proportion of male, shorter duration of disease, poorer islet function, higher blood glucose and more significant weight loss than non-ketotic T2DM patients.
PMID: 30482009 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - December 1, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Sleep apnea and cardiovascular complications of the acromegaly. Response to the medical treatment.
Authors: García-Alvarez M, Climent V
Abstract
Acromegaly is a rare disease characterized by high levels of growth hormone (GH) and insulin- like growth factor 1 (IGF-1). The excess of GH leads to the development of different manifestations in different organs, from subtle signs in the bones and soft tissues to the development of respiratory and cardiac insufficiency. In the cardiovascular system, the GH/IGF-1 axis exerts its influence on three major aspects: myocyte growth and structure, cardiac contractility and vascular function. In this article, we review the different cardiovascular and respiratory co...
Source: Minerva Endocrinologica - December 1, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
A multistep approach for the stratification of the risk of severe hypoglycemia in patients with type 2 diabetes.
CONCLUSIONS: The process led to the identification of relevant factors, to be used for the development of a hypoglycemia risk score. An ad-hoc study will be performed to assess the contribution of these risk factors and their relative weight. If the risk score will confirm its ability to correctly stratify patients according to their risk of hypoglycemia, it will represent a useful support to optimize the care of people with T2DM.
PMID: 30463398 [PubMed - in process] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 24, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Biochemical following-up of treated acromegaly. Limitations of the current determinations of IGF-1 and perspective.
CONCLUSIONS: We will focus on the issues regarding the measurement and interpretation of IGF-I concentrations in the management of acromegaly patients.
PMID: 30311754 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 14, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
The main predictors of the enlargement of ascending aorta in Turner syndrome: a cross-sectional contrast-enhanced magnetic resonance angiography study.
CONCLUSIONS: The main factors associated with the enlargement of ascending aorta in Turner syndrome were age, body surface area and bicuspid aortic valve, the relation between diameter of ascending aorta and bone mineral density was not identified.
PMID: 30290692 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - October 8, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Correlation between cytological and histological findings in patients who underwent thyroidectomy. Predictive value and confounders. Our experience.
CONCLUSIONS: These findings suggest that we need more studies to evaluate real BSRTC predictive value in single centers. Meanwhile we found out that thyroiditis may be a confounding factor in cytological examination wich would lead to an overstating of thyroid nodules.
PMID: 30256073 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 28, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Performance of low-dose cosyntropin stimulation test in the afternoon.
CONCLUSIONS: In healthy volunteers, using a 2.5 cm plastic tube, LDT provides comparable morning and afternoon 30-min stimulated SC and SFC concentration.
PMID: 30256074 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 28, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
