Lower irisin levels in coronary artery disease: a meta-analysis.
CONCLUSIONS: This study confirmed that irisin levels were significantly lower in patients with coronary artery disease.
PMID: 29160049 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Study on clinical indicators of diabetic retinopathy.
Authors: Jiao X, Li G, Yin X
PMID: 29160050 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Irisin as a regulator of bone and glucose metabolism: a narrative review.
Authors: Briganti SI, Gaspa G, Tabacco G, Naciu AM, Cesareo R, Manfrini S, Palermo A
Abstract
In humans, irisin is produced mainly by skeletal muscle in response to physical activity. It has been demonstrated that irisin plays a pivotal role in inducing fat browning and regulating energy expenditure. New findings from various studies conducted in both animals and humans suggest that irisin can affect bone and glucose metabolism. In particular, irisin is able to increase bone cortical mass by stimulating the osteoblast pathways, and irisin levels are inversely correlated with the incidence of fragility frac...
Source: Minerva Endocrinologica - November 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
An update on disorders of calcium, phosphate and bone.
Authors: Schalin-Jäntti C
PMID: 29160052 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 23, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
The relationship between the hormone levels before transplantation and outcomes of hormone replacement therapy-frozen embryo transfer.
CONCLUSION: The extent of decrease in serum estradiol and progesterone levels on the day before transplantation may be associated with outcome of HRT-FET.
PMID: 29125272 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 11, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Expression and clinical significance of EGF and TGF- Α in chronic pancreatitis and pancreatic cancer.
CONCLUSIONS: EGF and TGF-α have important research value as indicators to assess the progression of these conditions and provide a new basis for the clinical diagnosis.
PMID: 29125273 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - November 11, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Pseudohypoparathyroidism.
Authors: Cianferotti L, Brandi ML
Abstract
The term pseudohypoparathyroidism (PHP) refers to a spectrum of rare disorders of mineral metabolism, characterized by features due to end-organ resistance to PTH. The phenotypes of Albright hereditary osteodystrophy (AHO), originally described as associated to the disease, and progressive osseous heteroplasia, can be associated to the endocrine manifestations of hormonal resistance. Genetic or epigenetic alterations in the complex imprinted GNAS locus, encoding the alpha-subunit of the stimulatory G protein (GSα) and several other transcripts, give rise to the d...
Source: Minerva Endocrinologica - November 11, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Different therapeutic options in patients with Cushing's syndrome due to bilateral macronodular adrenal hyperplasia.
Authors: Albiger NM, Regazzo D, Iacobone M, Scaroni C
Abstract
Bilateral macronodular adrenal hyperplasia (BMAH) is a relatively rare cause of Cushing's syndrome (CS). In recent years, growing evidence has shown that steroidogenesis is regulated by aberrant G-protein-coupled receptors (GPCR) expression and their ligands, in a significant proportion of patients with BMAH. The screening of patients with overt or subclinical CS demonstrate the frequent expression of several GPCR that opened the option to potential therapeutic applications. Thus, several studies have demonstrated that targeting the involved re...
Source: Minerva Endocrinologica - November 8, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Clinical endocrinology and hormones quantitation: the increasing role of mass spectrometry.
Authors: D'Aurizio F, Cantù M
Abstract
Clinical endocrinology has always had a close relationship with laboratory medicine. In fact, the quantification of hormones is of great importance for diagnosis, treatment, recurrence and patient's prognosis of endocrine disorders. This review dealt with the role of the laboratory in diagnosing endocrine pathologies related to adrenal gland, pituitary, gonads and thyroid. The measurements of the main hormones (17- hydroxyprogesterone, androstenedione, dehydroepiandrosterone sulphate, testosterone, estradiol, cortisol, aldosterone, metanephrines, thyroglobulin and in...
Source: Minerva Endocrinologica - November 1, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Post-transplant diabetes: diagnosis and management.
Authors: Boerner BP, Shivaswamy V, Wolatz E, Larsen J
Abstract
Post-transplant diabetes mellitus (PTDM) is common after most types of solid organ transplantation, though the actual incidence is as yet unknown because of the use of different diagnostic criteria. PTDM is the result of individual risk factors as well as risk factors associated with the transplant itself, particularly immunosuppressants. Previously called New Onset Diabetes, in many cases inadequate screening for diabetes before transplant cannot assure that the diabetes is new after transplant. The most recent international consensus guidelin...
Source: Minerva Endocrinologica - October 12, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Autoimmune endocrine diseases.
Authors: Ruggeri RM, Giuffrida G, Campennì A
Abstract
The endocrine system is interested by several autoimmune diseases, characterized by different impact and severity, according to the organs involved. Autoimmune thyroid disorders (i.e. Hashimoto's thyroiditis and Graves' disease) and type 1 diabetes mellitus are the most common autoimmune endocrine disorders, while hypophysitis, adrenalitis (90% of cases of primary hypocortisolism or Addison's disease), premature ovarian failure and hypoparathyroidism represent quite rare conditions. Autoimmune endocrine diseases can also coexist in the same individuals...
Source: Minerva Endocrinologica - October 12, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Parathyroid carcinoma: a clinical and genetic perspective.
Authors: Cetani F, Pardi E, Marcocci C
Abstract
Parathyroid carcinoma (PC) is a rare neoplasia difficult to diagnose preoperatively. It mainly occurs as a sporadic disease but also as part of familial PHPT. At variance with patients with the benign counterpart, the phenotype of these patients is characterized by a severe primary hyperparathyroidism (PHPT). The clinical features are mostly due to the effects of the excessive secretion of PTH by the functioning tumor and hypercalcemia rather than to the tumor burden. The prognosis is poor and unmanageable hypercalcemia accounts for death in the majority of c...
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Role of positron emission tomography in thyroid and neuroendocrine tumours.
CONCLUSIONS: PET imaging with different radiotracers is a useful functional imaging technique in the work-up of several endocrine tumours.
PMID: 28949122 [PubMed - as supplied by publisher] (Source: Minerva Endocrinologica)
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Endocrine and neuroendocrine cytopathology.
Authors: Bongiovanni M, LA Rosa S, Sykiotis GP
Abstract
Cytology is an easily accessible, cost-effective and safe procedure for the initial evaluation of most endocrine/neuroendocrine lesions. Both fine-needle aspiration cytology and exfoliative cytology have shown good sensitivity and specificity in detecting endocrine/neuroendocrine benign proliferations and malignancies. Thanks to its utility for early diagnosis, cytology has contributed to the decline in mortality of endocrine/neuroendocrine neoplasms. The endocrine system comprises different endocrine organs, such as the thyroid, adrenal glands, parag...
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Diagnosis and management of Zollinger-Ellison syndrome in 2017.
Authors: DE Angelis C, Cortegoso Valdivia P, Venezia L, Bruno M, Pellicano R
Abstract
Zollinger-Ellison Syndrome (ZES) is a clinical syndrome characterized by gastric acid hypersecretion due to the ectopic secretion of gastrin by a gastrinoma, a neuroendocrine tumor (NET) which mostly develops in the duodenum and in the pancreas. This syndrome was first described by Zollinger and Ellison in 1964; if left untreated, ZES can lead to multiple complications mainly due to gastric hypersecretion and some patients can suffer from the complications of an advanced metastatic disease. Although its clinical features ...
Source: Minerva Endocrinologica - September 28, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
