Cryptococcus gattii infection in an immunocompetent host in Greece
We report a case of a 31-year-old otherwise healthy female with pulmonary cryptococcoma along with cryptococcal meningitis due to Cryptococcus gattii molecular type VGI, in Greece. Combined antifungal treatment and surgical excision of pulmonary cryptococcoma yielded a good response. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - December 4, 2019 Category: Biology Source Type: research
Multi-fungal sepsis and mucormycosis of the central nervous system in a patient treated with ibrutinib, a case report and review of the literature
We report the case of a 71 years old patient with chronic lymphocytic leukemia (CLL), who developed a rapidly progressing multi-fungal infection including mucormycosis of the central nervous system (CNS) during treatment with ibrutinib.On autopsy mucorales species were demonstrated intravascularly by histomorphology of several organs and lymph nodes and were characterized as Rhizomucor pusillus by polymerase-chain reaction (PCR) – analysis. In addition, invasive pulmonary Aspergillus fumigatus was found and also confirmed by PCR. To the best of our knowledge, this is the first confirmation of a multi-fungal sepsis and in...
Source: Medical Mycology Case Reports - December 3, 2019 Category: Biology Source Type: research
False-negative result of serum cryptococcal antigen lateral flow assay in an HIV-infected patient with culture-proven cryptococcaemia
We report the case of an HIV-infected patient with CD4 = 42 cells/mL, asthenic, negative serum CrAg lateral flow assay (LFA) and culture-proven cryptococcaemia. Despite the high accuracy of LFA, false-negative is possible and careful clinical evaluation and close follow-up are relevant. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - November 3, 2019 Category: Biology Source Type: research
Invasive dermatophytosis mimicking vasculitis
We report a case of invasive dermatophytosis mimicking vasculitis. A patient consulted the Department of Dermatology, Zealand University Hospital, Roskilde, Denmark for the assessment of violaceous/erythematous lesions thought to be vasculitis. She had prior to this been treated with the immunosuppressive drug teriflunomid. Due to the lesion's erythematous scaling boarder invasive dermatophytosis was suspected. By using direct microscopy a mycological diagnosis was confirmed. We underline the utility of direct microscopy in the diagnosis. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - November 1, 2019 Category: Biology Source Type: research
Meningeal and multiorgan disseminated sporotrichosis: A case report and autopsy study
Publication date: Available online 31 October 2019Source: Medical Mycology Case ReportsAuthor(s): Helena Duani, Marina Fernandes Palmerston, Jésus Faria Rosa Júnior, Vitor Teatini Ribeiro, Pedro Lobo Alcântara NevesAbstractThis case report presents a 36-year old man with a disseminated sporotrichosis who presented with seizures and crusted lesions all over the body. Imaging studies revealed acute ischemic brain event with haemorrhagic transformation in right frontal lobe. Skin biopsy showed Sporothrix schenckii. He was treated with standard amphotericin B. Despite therapy, he developed consciousness loss, multiorgan-fai...
Source: Medical Mycology Case Reports - November 1, 2019 Category: Biology Source Type: research
Auxarthron alboluteum related to non-dermatophytic toenail infection in Kurdistan region, Iraq: A case report
We report a rare case of non-dermatophytic onychomycosis of the big toenail caused by Auxarthron alboluteum in a 63-years old Iraqi female with a history of diabetes. The big toenail showed distal subungual onychomycosis with extensive yellow-white discoloration. Identification of the causative agent was confirmed by morphological and microscopical characteristics in culture and analysis of ITS-rDNA region. To the best of our knowledge, the isolated Auxarthron alboluteum reported here is a new etiologic species of nail infection in Iraq and this is the first case of its kind to be reported in the world. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - November 1, 2019 Category: Biology Source Type: research
Presentation of histoplasmosis as mononucleosis syndrome in an immunocompetent patient
We present the case of an 18 year-old immunocompetent, male patient, resident of the State of Florida, who showed signs of mononucleosis syndrome that included odynophagia, cervical adenomegaly, sporadic fever and rash; however, no pulmonary involvement or visceromegaly were present. Faced with this atypical and unexpected clinical picture, histoplasmosis infection was eventually diagnosed following cervical lymph-node biopsy. Disseminated histoplasmosis may have unexpected manifestations, as is pointed out in the case described below. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - October 31, 2019 Category: Biology Source Type: research
An unusual case of cutaneous feline pythiosis
Publication date: Available online 31 October 2019Source: Medical Mycology Case ReportsAuthor(s): Megan Dowst, Alana Pavuk, Raquel Vilela, Camila Vilela, Leonel MendozaAbstractPythiosis is frequently reported in dogs and horses inhabiting tropical, subtropical and temperate areas of the USA, but the disease is rare in domestic cats. The clinical presentation of feline pythiosis includes subcutaneous masses without ulcerated tissue and involvement of the intestinal tract. Here in we report an eight-week-old female unvaccinated stray kitten with an unusual extensive circular ulcerated lesion on her left flank. The lesion did...
Source: Medical Mycology Case Reports - October 31, 2019 Category: Biology Source Type: research
Cutaneous mucormycosis by Rhizopus arrhizus treated with isavuconazole as first line therapy: A case report
We report the case of 67-year-old man with idiopathic granulocytic aplasia and a cutaneous lesion caused by Rhizopus arrhizus treated with isavuconazole. Its safety profile and spectrum of activity make it an important therapeutic option. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - October 4, 2019 Category: Biology Source Type: research
Disseminated gastrointestinal basidiobolomycosis (GIB) in an infant from western India
Publication date: Available online 3 October 2019Source: Medical Mycology Case ReportsAuthor(s): Anuradha Sharma, Rahul Saxena, Arvind Sinha, Shambhavi Singh, Taruna YadavAbstractBasidiobolomycosis is an infection due to the fungus Basidiobolus ranarum, an environmental saprophyte found worldwide. We are reporting youngest case of Gastrointestinal Basidiobolomycosis (GIB) in a two month old boy from India. He presented with a mass in right iliac fossa with the signs of intestinal obstruction. Histopathology of the lesion showed broad aseptate hyphae. It disseminated to kidneys. Aspirate culture from nephrostomy yielded gro...
Source: Medical Mycology Case Reports - October 4, 2019 Category: Biology Source Type: research
First case report of fulminant septic shock from meningococcemia associated with Cryptococcus neoformans coinfection in an immunocompetent patient
We describe a case of an immunocompetent 74-year-old Caucasian woman who presented with fulminant acute meningococcemia associated with cryptococcal meningitis, which progressed to worsening general condition and died of septic shock and multiple organ dysfunctions in less than 48 hours. This case report demonstrates the possibility of coinfections related to Neisseria meningitidis and Cryptococcus neoformans, even in immunocompetent patients, which represent a diagnostic challenge for clinicians, thus encouraging further studies for a better understanding. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - October 4, 2019 Category: Biology Source Type: research
Case report of penile Rhizopus arrhizus infection in an unexpected patient
Publication date: Available online 25 September 2019Source: Medical Mycology Case ReportsAuthor(s): Matthew Bezzant, Kathryn Lago, Tatjana CalvanoAbstractThere are few reports of penile mucormycosis and even fewer in the absence of overt immune suppression. An eighty year old male with diabetes presents with penile mass. The pathology and culture demonstrated Rhizopus arrhizus. He was treated with surgery and liposomal amphotericin B. His therapy was stopped after pathology demonstrated clear surgical margins. His good outcome provides evidence that stopping antifungal therapy after achieving clear surgical margins is acce...
Source: Medical Mycology Case Reports - September 26, 2019 Category: Biology Source Type: research
Fungal aneurism of the right posterior inferior cerebellar artery (PICA)
Publication date: Available online 25 September 2019Source: Medical Mycology Case ReportsAuthor(s): Stefano Tambuzzi, Michele Boracchi, Francesca Maciocco, Cristina Tonello, Guendalina Gentile, Riccardo ZojaAbstractIn this case-report, the Authors show the case of a sudden death occurred in a 38-year-old woman submitted to surgical excision of a right acoustic neurinoma. At the autopsy, was detected a cerebral hemorrhage with multifocal localization by a ruptured rare fungal aneurysm of the Posterior Inferior Cerebellar Arthery (PICA). The PCR analysis, carried out on formalin-fixed paraffin-embedded tissue, identified the...
Source: Medical Mycology Case Reports - September 26, 2019 Category: Biology Source Type: research
Combination of amphotericin B and caspofungin in the treatment of mucormycosis
We report a case of invasive mucormycosis in 52 year-old woman. CT-scan and magnetic resonance imaging found a partial right sinus thrombosis associated with homolateral ethmoidal and maxillary sinusitis with submucosal inflammation. Histopathological examination of excised tissue was positive for mucormycosis. Our patient was treated by surgical debridement and a combination of amphotericin B and caspofungin, with a good outcome. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - September 22, 2019 Category: Biology Source Type: research
Recurrent eumycetoma caused by novel species Madurella pseudomycetomatis: A case report
We present a case of madura foot with novel etiologic agent Madurella pseudomycetomatis. Diagnosis was based on morphologic, physiologic, histipathologic and molecular methods. In vitro antifungal susceptibility tests revealed that MIC values for itraconazole, amphotericin B, and posaconazole were 0.0313 μg/ml, 0.0313μg/ml, and 0.004 μg/ml, respectively. The patient was treated and recovered by itraconazole(400 mg/day) after prolonged course. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - September 22, 2019 Category: Biology Source Type: research
