Breaking the Mold: A case of pulmonary mucormycosis treated with isavuconazole
Publication date: Available online 1 December 2018Source: Medical Mycology Case ReportsAuthor(s): Jonathan Huggins, Ayman Al Jurdi, Renuka GuptaAbstractPulmonary mucormycosis is a rare opportunistic invasive fungal infection that disproportionately affects immunocompromised hosts and carries high morbidity and mortality. It is traditionally treated with combined pharmacologic and surgical modalities. Here we present a case of pulmonary mucormycosis in a patient whose disease burden precluded surgical management, and in whom acute kidney injury necessitated therapy with an alternative to the recommended pharmacologic antifu...
Source: Medical Mycology Case Reports - December 1, 2018 Category: Biology Source Type: research
Saccharomyces cerevisiae fungemia in a critically ill patient with acute cholangitis and long term probiotic use
We report a case of a 74-year-old man admitted for acute cholangitis taking a probiotic supplement containing the subtype Saccharomyces boulardii. He later developed S. cerevisiae fungemia that was successfully treated with Micafungin and Fluconazole. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - November 14, 2018 Category: Biology Source Type: research
Palate ulcer, uvular destruction and nasal septal perforation caused by Sporothrix brasiliensis in an HIV-infected patient
We report a dramatic presentation of Sporothrix brasiliensis infection, with destruction of the nasal septum, soft palate, and uvula of an HIV-infected woman. She was successfully treated with amphotericin B deoxycholate followed by itraconazole. Sporotrichosis remains a neglected opportunistic infection in patients with AIDS and awareness of this potentially fatal infection is of utmost importance. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - November 14, 2018 Category: Biology Source Type: research
Chronic pulmonary aspergillosis following pulmonary embolism
We describe a case of CPA in a 79-year-old female following bilateral pulmonary emboli. The clinical implications are numerous, including the dilemma of anticoagulation. This link suggests that a lower threshold for suspecting CPA following pulmonary embolus is required, even in the absence of other respiratory disease. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - November 11, 2018 Category: Biology Source Type: research
Treatment of cerebral mucormycosis with drug therapy alone: A case report
We report on an elderly male patient with headache and right-side weakness. Imaging studies revealed multiple space-occupying lesions in the parietal and occipital cerebral regions. Biopsy revealed broad aseptate ribbon-like structures branching at right angles, suggestive of mucormycosis. Improvement was observed after medical therapy with 20 weeks of liposomal amphotericin B (5 mg/kg/day) combined with posaconazole, followed by posaconazole (400 mg twice a day) alone for 1 month. The patient recovered without neurological deficits; however, multidrug-resistant bacteraemia and hospital-acquired pneumonia occurre...
Source: Medical Mycology Case Reports - October 29, 2018 Category: Biology Source Type: research
Deep cutaneous Trichosporon asahii infection in a patient recovering from toxic epidermal necrolysis
We present a case of a patient who developed a deep cutaneous fungal infection caused by Trichosporon asahii and discuss the management. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - October 27, 2018 Category: Biology Source Type: research
Purpuriocillium lilacinum infection in captive loggerhead sea turtle hatchlings
Publication date: Available online 25 October 2018Source: Medical Mycology Case ReportsAuthor(s): Clarisse Máximo Arpini, Yhuri Cardoso Nóbrega, Vinícius Davel Castheloge, Daniel Santos Neves, Carlos Eduardo Tadokoro, Gisela Lara da Costa, Manoel Marques Evangelista Oliveira, Marcelo Renan de Deus SantosAbstractThis paper reports a case of Purpureocillium lilacinum infection in seven loggerhead sea turtle (Caretta caretta) hatchlings kept in an aquarium under inadequate condition. The fungus was isolated from skin and pulmonary lesions. Metilene blue and NaCl solutions, Schinus terebinthifolius and eucalyptus essential ...
Source: Medical Mycology Case Reports - October 25, 2018 Category: Biology Source Type: research
Aspergillus Endocarditis Diagnosed by Fungemia Plus Serum Antigen Testing
Publication date: Available online 25 October 2018Source: Medical Mycology Case ReportsAuthor(s): Timothy J. Hatlen, Scott G. Filler, Arnold Bayer, Sonia Shah, Shivani Shodhan, Tam T. VanAbstractFungal endocarditis remains an uncommon clinical diagnosis, though is likely to become more frequent due to the global increase in transplantations and cardiac valvular surgery. A case of prosthetic valve endocarditis due to Aspergillus fumigatus is described that was diagnosed with serologic fungal markers and confirmed with positive blood cultures, an uncommon finding. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - October 25, 2018 Category: Biology Source Type: research
Invasive fungal infection by Aspergillus flavus in immunocompetent hosts: a case series and literature review
Publication date: Available online 25 October 2018Source: Medical Mycology Case ReportsAuthor(s): Ana María Garcia-Giraldo, Barbara Lucia Mora, Jorge Mario Loaiza-Castaño, Jorge Andrés Cedano, Fernando RossoAbstractInvasive aspergillosis usually affects immunocompromised hosts with variable manifestations depending on the site of infection. In this article, we present two cases of invasive Aspergillosis in two non-immunocompromised patients; both cases had a paranasal sinuses infection, with intraorbital and intracranial extension, requiring surgery and antifungal treatment with Voriconazole. These cases were initially ...
Source: Medical Mycology Case Reports - October 25, 2018 Category: Biology Source Type: research
Exophiala psychrophila: a new agent of chromoblastomycosis
We report a woman who was treated before with mycological cure, but she experience a relapse requiring treatment again. Direct microscopic examination and skin biopsy with culture were necessary to identify a Exophiala psychrophila, and for our knowledge this is the first case reported. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - October 25, 2018 Category: Biology Source Type: research
Posaconazole and isavuconazole induced hypomagnesaemia
Publication date: Available online 28 September 2018Source: Medical Mycology Case ReportsAuthor(s): John Burston, Mark Robertson, Sebastian van Hal, Angie N. Pinto (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - October 5, 2018 Category: Biology Source Type: research
Aspergillus fumigatus endocarditis in an Indigenous Australian male without classic risk factors
We present the case of an “immunocompetent” Indigenous Australian male with culture confirmed Aspergillus brain abscesses complicating bilateral endocarditis. The reported mortality rate for Aspergillus endocarditis approaches 100%. Despite sub-optimal therapy this patient survived beyond expectation. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - September 22, 2018 Category: Biology Source Type: research
Blastoschizomyces capitatus pneumonia in a patient with untreated chronic lymphocytic leukemia
We report a case of pulmonary infection by B. capitatus in a patient with untreated chronic lymphocytic leukemia. Although the patient had a complete recovery, we believe that this report will alert clinicians to consider B. capitatus as possible cause of severe pneumonia in untreated CLL. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - September 22, 2018 Category: Biology Source Type: research
Invasive rhinocerebral mucormycosis in a patient with liver cirrhosis leading to fatal massive stroke
Publication date: Available online 21 September 2018Source: Medical Mycology Case ReportsAuthor(s): Taher Sabobeh, Kamran Mushtaq, Ahmed Elsotouhy, Adham A. Ammar, Sameera RashidAbstractImmunocompromised status is associated with invasive fungal infections including mucormycosis. These infections are challenging to treat and associated with high overall mortality.Here we report a fatal case of invasive mucormycosis in a cirrhotic, diabetic patient. Despite the swift diagnosis and management; the fungal invasion of the right internal carotid artery lead to massive ischemic stroke.Timely diagnosis and management is crucial f...
Source: Medical Mycology Case Reports - September 22, 2018 Category: Biology Source Type: research
Utilization of Voriconazole Drug Monitoring in the Treatment of Cutaneous Scedosporium apiospermum Infection
We report the use of voriconazole troughs to achieve appropriate therapeutic levels in treatment of a cutaneous Scedosporium apiospermum infection. Following heart transplantation, a 63-year-old immunocompromised patient presented with post-traumatic nodular lesions on his right shin. Pathology showed fungal yeasts with culture revealing Scedosporium apiospermum. According to therapeutic drug monitoring, initial voriconazole treatment was subtherapeutic requiring increased dosing until appropriate therapeutic trough levels were attained, and resolution of the fungal infection was achieved. (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - September 14, 2018 Category: Biology Source Type: research
