Contribution of NRG1 Gene Polymorphisms in Temporal Lobe Epilepsy
The purpose of the present study was to investigate the possible association between temporal lobe epilepsy and NRG1 gene polymorphisms. A total of 73 patients and 69 controls were involved in this study. Genomic DNAs from the patients and controls were genotyped by polymerase chain reaction-ligase detection reaction method. There was an association of rs35753505 (T>C) with temporal lobe epilepsy (2 = 6.730, P = .035). The frequency of risk allele C of rs35753505 was significantly higher (69.9%) in patients compared to controls (55.8%) (2 = 6.023, P = .014). Interestingly, the significant difference of NRG1 genotype and...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Zhu, W.-Y., Jiang, P., He, X., Cao, L.-J., Zhang, L.-H., Dang, R.-L., Tang, M.-M., Xue, Y., Li, H.-D. Tags: Original Articles Source Type: research
JCN Calendar of Events
(Source: Journal of Child Neurology)
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Tags: & lt;I gt;JCN lt;/I gt; Calendar of Events Source Type: research
Book Review: Principles and Practice of Pediatric Neurosurgery
(Source: Journal of Child Neurology)
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: Sribnick, E. A. Tags: Book Reviews Source Type: research
Book Review: A Practical Approach to Neurophysiologic Intraoperative Monitoring
(Source: Journal of Child Neurology)
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: McKinney, J. L. Tags: Book Reviews Source Type: research
Diagnostic Approach to Genetic Causes of Early-Onset Epileptic Encephalopathy
Epileptic encephalopathies are characterized by recurrent clinical seizures and prominent interictal epileptiform discharges seen during the early infantile period. Although epileptic encephalopathies are mostly associated with structural brain defects and inherited metabolic disorders, pathogenic gene mutations may also be involved in the development of epileptic encephalopathies even when no clear genetic inheritance patterns or consanguinity exist. The most common epileptic encephalopathies are Ohtahara syndrome, early myoclonic encephalopathy, epilepsy of infancy with migrating focal seizures, West syndrome and Dravet ...
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: Gürsoy, S., Ercal, D. Tags: Topical Review Articles Source Type: research
Low Grade Gliomas in Children
Gliomas represent the most common solid tumor of the nervous system, and can occur as both low and high-grade tumors. Current risk stratification and treatment approaches rely heavily on the morphological classification of gliomas whereby low-grade gliomas have an excellent prognosis, particularly pilocytic astrocytomas, while high-grade gliomas have a poor prognosis. The past decade has witnessed a dramatic increase in scholars’ knowledge of the biology of pediatric low-grade gliomas particularly through the advent of integrated genomics and next generation sequencing. Indeed, many of these biological advances are c...
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: Chalil, A., Ramaswamy, V. Tags: Topical Review Articles Source Type: research
Advances in Radiation Therapy in Pediatric Neuro-oncology
Radiation therapy remains a highly effective therapy for many pediatric central nervous system tumors. With more children achieving long-term survival after treatment for brain tumors, late-effects of radiation have become an important concern. In response to this problem, treatment protocols for a variety of pediatric central nervous system tumors have evolved to reduce radiation fields and doses when possible. Recent advances in radiation technology such as image guidance and proton therapy have led to a new era of precision treatment with significantly less exposure to healthy tissues. These developments along with the ...
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: Bindra, R. S., Wolden, S. L. Tags: Topical Review Articles Source Type: research
Improving Care in Pediatric Neuro-oncology Patients: An Overview of the Unique Needs of Children With Brain Tumors
Brain tumors represent the most common solid tumors in childhood, accounting for almost 25% of all childhood cancer, second only to leukemia. Pediatric central nervous system tumors encompass a wide variety of diagnoses, from benign to malignant. Any brain tumor can be associated with significant morbidity, even when low grade, and mortality from pediatric central nervous system tumors is disproportionately high compared to other childhood malignancies. Management of children with central nervous system tumors requires knowledge of the unique aspects of care associated with this particular patient population, beyond genera...
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: Fischer, C., Petriccione, M., Donzelli, M., Pottenger, E. Tags: Topical Review Articles Source Type: research
Remote Assessment of Cognitive Function in Juvenile Neuronal Ceroid Lipofuscinosis (Batten disease): A Pilot Study of Feasibility and Reliability
Remote technology provides an opportunity to extend the reach of clinical care and research for pediatric rare disease. This pilot study evaluated the feasibility and reliability of neuropsychological evaluation, using remote audiovisual technology, in the assessment of children with juvenile Batten disease. Three children with Batten disease and 1 healthy sibling completed a standardized cognitive assessment. Results indicated high agreement between an in-person and a remote evaluator when comparing the subjects’ cognitive test scores. This initial test of remote cognitive assessment suggests it is feasible and reli...
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: Ragbeer, S. N., Augustine, E. F., Mink, J. W., Thatcher, A. R., Vierhile, A. E., Adams, H. R. Tags: Original Articles Source Type: research
Can Clinical Assessment of Locomotive Body Function Explain Gross Motor Environmental Performance in Cerebral Palsy?
Gross Motor Function Classification System has discriminative purposes but does not assess short-term therapy goals. Locomotion Stages (LS) classify postural body functions and independent activity components. Assessing the relation between Gross Motor Function Classification System level and Locomotion Stages will make us understand if clinical assessment can explain and predict motor environmental performance in cerebral palsy. A total of 462 children were assessed with both scales. High reliability and strong negative correlation (–0.908) for Gross Motor Function Classification System and Locomotion Stages at any ...
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: Sanz Mengibar, J. M., Santonja-Medina, F., Sanchez-de-Muniain, P., Canteras-Jordana, M. Tags: Original Articles Source Type: research
Prevalence and Clinical Characteristics of Headaches in PHACE Syndrome
The objective of this study was to characterize the clinical features and prevalence of headache by conducting a cross-sectional survey of families in 2 large PHACE registries. Sixty-six percent of eligible families completed the survey in which 62.7% of respondents reported headaches. Average age of headache onset was 48.8 months. Females were more likely to have headaches (68.6% vs 30.8%, P = .014). Families reported associated migrainous features including nausea (62.5%), vomiting (37.5%), photophobia (75%), and phonophobia (75%). Headaches occurred at least weekly in 29.4%, lasted ≥1 hour in 85.4%, and led to ≥1 ...
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: Yu, J., Siegel, D. H., Drolet, B. A., Blei, F., Epstein, L. G., Metry, D., Heyer, G. L. Tags: Original Articles Source Type: research
Persistence of Cerebral Palsy Diagnosis: Assessment of a Low-Birth-Weight Cohort at Ages 2, 6, and 9 Years
We examined the stability of nondisabling and disabling cerebral palsy at age 2 in a longitudinally followed tri-county low-birth-weight (<2000 g) birth cohort. A total of 1105 newborns were enrolled, 901 (81.5%) survived to age 2, and 86% (n = 777) were followed up. Of the 113 cerebral palsy diagnoses at age 2, 61 (9% of the cohort, n = 61/777) had disabling cerebral palsy and 52 (7%, n = 52/777) had nondisabling cerebral palsy. Of 48 followed children diagnosed with disabling cerebral palsy at age 2, 98% were again classified as having cerebral palsy at school age, and 1 had an uncertain cerebral palsy status. By cont...
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: Korzeniewski, S. J., Feldman, J. F., Lorenz, J. M., Pinto-Martin, J. A., Whitaker, A. H., Paneth, N. Tags: Original Articles Source Type: research
Strabismus at Age 2 Years in Children Born Before 28 Weeks Gestation: Antecedents and Correlates
Children born very preterm are at greater risk of ophthalmic morbidities, including strabismus, than children born at term. We evaluated perinatal factors associated with strabismus at age 2 years in a large population of infants delivered before 28 weeks’ gestation. A total of 996 infants in the multicenter ELGAN (Extremely Low Gestational Age Newborn) study who had a retinal exam in infancy and a developmental assessment at 2 years corrected age are included. Their mothers were interviewed about the pregnancy, and both mother and newborn charts were reviewed. Certified examiners administered the Bayley Scales of In...
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: VanderVeen, D. K., Allred, E. N., Wallace, D. K., Leviton, A., for the ELGAN Study Investigators Tags: Original Articles Source Type: research
Pilot Testing Behavior Therapy for Chronic Tic Disorders in Neurology and Developmental Pediatrics Clinics
Comprehensive Behavioral Intervention for Tics (CBIT) is an efficacious treatment with limited regional availability. As neurology and pediatric clinics are often the first point of therapeutic contact for individuals with tics, the present study assessed preliminary treatment response, acceptability, and feasibility of an abbreviated version, modified for child neurology and developmental pediatrics clinics. Fourteen youth (9-17) with Tourette disorder across 2 child neurology clinics and one developmental pediatrics clinic participated in a small case series. Clinician-rated tic severity (Yale Global Tic Severity Scale) ...
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: Ricketts, E. J., Gilbert, D. L., Zinner, S. H., Mink, J. W., Lipps, T. D., Wiegand, G. A., Vierhile, A. E., Ely, L. J., Piacentini, J., Walkup, J. T., Woods, D. W. Tags: Original Articles Source Type: research
Children Experiencing First-Time or Prolonged Febrile Seizure Are Prone to Stress Hyperglycemia
The risk factors and clinical implications of stress hyperglycemia in children with febrile seizure remain uncertain. Among 479 children with febrile seizure, the prevalence of the stress hyperglycemia (blood glucose concentration ≥ 150 mg/dL) was 10.0%. Stress hyperglycemia group included larger proportion of first-time febrile seizure, prolonged febrile seizure, and smaller proportion of short febrile seizure in comparison with the non–stress hyperglycemia group. Stress hyperglycemia group demonstrated a lower pH and higher lactate levels than the non–stress hyperglycemia group. Multivariate analysis revea...
Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: Lee, J.-Y., Kim, J.-H., Cho, H.-R., Lee, J.-S., Ryu, J.-M., Yum, M.-S., Ko, T.-S. Tags: Original Articles Source Type: research
