Feasibility of Automatic Extraction of Electronic Health Data to Evaluate a Status Epilepticus Clinical Protocol
Status epilepticus is a common neurologic emergency in children. Pediatric medical centers often develop protocols to standardize care. Widespread adoption of electronic health records by hospitals affords the opportunity for clinicians to rapidly, and electronically evaluate protocol adherence. We reviewed the clinical data of a small sample of 7 children with status epilepticus, in order to (1) qualitatively determine the feasibility of automated data extraction and (2) demonstrate a timeline-style visualization of each patient’s first 24 hours of care. Qualitatively, our observations indicate that most clinical da...
Source: Journal of Child Neurology - April 12, 2016 Category: Neurology Authors: Hafeez, B., Paolicchi, J., Pon, S., Howell, J. D., Grinspan, Z. M. Tags: Original Articles Source Type: research
Neurologic Complications Caused by Epstein-Barr Virus in Pediatric Patients
We retrospectively analyzed the medical documentation of 194 children infected with Epstein-Barr virus. The diagnosis was based on clinical symptoms and the presence of the viral capsid antigen IgM antibody. Patients with severe neurologic complications also underwent neurologic examination, magnetic resonance imaging (MRI), and electroencephalography (EEG). There were 2 peaks in incidence of infection; the first one in young children aged 1 to 5 years represented 62.0% of cases. The second peak (24.6% of patients) occurred in teenagers. Febrile seizures were confirmed in 3.1% of affected children younger than 5 years and ...
Source: Journal of Child Neurology - April 12, 2016 Category: Neurology Authors: Mazur-Melewska, K., Brenska, I., Jonczyk-Potoczna, K., Kemnitz, P., Pieczonka-Ruszkowska, I., Mania, A., Słuzewski, W., Figlerowicz, M. Tags: Original Articles Source Type: research
The Diagnostic Yield of Array Comparative Genomic Hybridization Is High Regardless of Severity of Intellectual Disability/Developmental Delay in Children
Microarray-based comparative genomic hybridization is a method of molecular analysis that identifies chromosomal anomalies (or copy number variants) that correlate with clinical phenotypes. The aim of the present study was to apply a clinical score previously designated by de Vries to 329 patients with intellectual disability/developmental disorder (intellectual disability/developmental delay) referred to our tertiary center and to see whether the clinical factors are associated with a positive outcome of aCGH analyses. Another goal was to test the association between a positive microarray-based comparative genomic hybridi...
Source: Journal of Child Neurology - April 12, 2016 Category: Neurology Authors: DArrigo, S., Gavazzi, F., Alfei, E., Zuffardi, O., Montomoli, C., Corso, B., Buzzi, E., Sciacca, F. L., Bulgheroni, S., Riva, D., Pantaleoni, C. Tags: Original Articles Source Type: research
Neurodevelopmental and Behavioral Outcomes in Children With Sepsis-Associated Encephalopathy Admitted to Pediatric Intensive Care Unit: A Prospective Case Control Study
In conclusion, children with sepsis-associated encephalopathy have delayed neurodevelopment, low verbal IQ, decline in school performance and low intelligence at short-term follow-up. Irritability, shock and duration of sedation are associated with poor behavioral outcomes, especially scholastic performance. (Source: Journal of Child Neurology)
Source: Journal of Child Neurology - April 12, 2016 Category: Neurology Authors: Kaur, J., Singhi, P., Singhi, S., Malhi, P., Saini, A. G. Tags: Original Articles Source Type: research
The Role of Prematurity in Patients With Hemiplegic Cerebral Palsy
A multicenter retrospective study was conducted to investigate the perinatal factors, imaging findings and clinical characteristics of hemiplegic cerebral palsy with a particular focus on children born prematurely. Our cohort included 135 patients of whom 42% were born prematurely; 16% were extreme premature infants who were born at 30 weeks or earlier. Nineteen (14%) were twins. Right hemiplegia was slightly more common and accounted for 59% of the patients. Imaging findings of intraventricular hemorrhage and periventricular leukomalacia were more prevalent in premature children whereas stroke, porencephaly, cerebral hemo...
Source: Journal of Child Neurology - April 12, 2016 Category: Neurology Authors: Zelnik, N., Lahat, E., Heyman, E., Livne, A., Schertz, M., Sagie, L., Fattal-Valevski, A. Tags: Original Articles Source Type: research
Association of Interleukin-1 Gene Cluster and Interleukin-1 Receptor Polymorphisms With Febrile Seizures
Interleukin-1 (IL-1) plays a key role in inflammation, has an effect on a wide variety of cells, and often leads to tissue destruction. While the ratio between IL-1 and IL-1Ra could influence the development of different diseases of the central nervous system, its gene polymorphisms were investigated in a group of patients with febrile seizures. Ninety patients with febrile seizures were enrolled and compared with 140 controls. The allele and genotype frequency of single nucleotide polymorphisms within the IL-1α, β, IL-1 R and IL-1Ra gene were determined. The frequency of the IL-1Ra/C allele at position Mspa-I 1...
Source: Journal of Child Neurology - April 12, 2016 Category: Neurology Authors: Soltani, S., Zare-Shahabadi, A., Shahrokhi, A., Rezaei, A., Zoghi, S., Zamani, G. R., Mohammadi, M., Ashrafi, M. R., Rezaei, N. Tags: Original Articles Source Type: research
JCN Calendar of Events
(Source: Journal of Child Neurology)
Source: Journal of Child Neurology - March 16, 2016 Category: Neurology Tags: & lt;I gt;JCN lt;/I gt; Calendar of Events Source Type: research
The Eye on Mitochondrial Disorders
Ophthalmologic manifestations of mitochondrial disorders are frequently neglected or overlooked because they are often not regarded as part of the phenotype. This review aims at summarizing and discussing the etiology, pathogenesis, diagnosis, and treatment of ophthalmologic manifestations of mitochondrial disorders. Review of publications about ophthalmologic involvement in mitochondrial disorders by search of Medline applying appropriate search terms. The eye is frequently affected by syndromic as well as nonsyndromic mitochondrial disorders. Primary and secondary ophthalmologic manifestations can be differentiated. The ...
Source: Journal of Child Neurology - March 16, 2016 Category: Neurology Authors: Finsterer, J., Zarrouk-Mahjoub, S., Daruich, A. Tags: Topical Review Article Source Type: research
Pial Synangiosis Ameliorates Movement Disorders in the Absence of Prior Stroke in Moyamoya Disease
Conclusions:
Moyamoya disease is an important and surgically treatable cause of movement disorders. (Source: Journal of Child Neurology)
Source: Journal of Child Neurology - March 16, 2016 Category: Neurology Authors: Greene, S., Bansal, L., Coffman, K. A., Nardone, R., Zuccoli, G. Tags: Original Articles Source Type: research
Topographical Distribution of Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex
Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the in...
Source: Journal of Child Neurology - March 16, 2016 Category: Neurology Authors: Ellingson, B. M., Hirata, Y., Yogi, A., Karavaeva, E., Leu, K., Woodworth, D. C., Harris, R. J., Enzmann, D. R., Wu, J. Y., Mathern, G. W., Salamon, N. Tags: Original Articles Source Type: research
Increased Serum Phthalates (MEHP, DEHP) and Bisphenol A Concentrations in Children With Autism Spectrum Disorder: The Role of Endocrine Disruptors in Autism Etiopathogenesis
The aim of this study was to investigate the relationship between autism spectrum disorders development and exposure to mono-(2-ethylhexyl)-phthalate (MEHP), di-(2-ethylhexyl)-phthalate (DEHP), and bisphenol A (BPA), 1 of the endocrine disruptors, among phthalates. The study included 48 children with autism spectrum disorder (27 boys, 21 girls) and 41 healthy subjects (24 boys, 17 girls) as controls. Serum MEHP, DEHP, and BPA levels were measured by using high-performance liquid chromatography. Children with autism spectrum disorder had significantly increased serum MEHP, DEHP, and BPA concentrations (0.47 ± 0.14 &m...
Source: Journal of Child Neurology - March 16, 2016 Category: Neurology Authors: Kardas, F., Bayram, A. K., Demirci, E., Akin, L., Ozmen, S., Kendirci, M., Canpolat, M., Oztop, D. B., Narin, F., Gumus, H., Kumandas, S., Per, H. Tags: Original Articles Source Type: research
Presumed Perinatal Stroke: Risk Factors, Clinical and Radiological Findings
It is unknown why some infants with perinatal stroke present clinical symptoms late during infancy and will be identified as infants with presumed perinatal stroke. The risk factors and clinical and radiological data of 42 infants with presumed perinatal stroke (69% with periventricular venous infarction and 31% with arterial ischemic stroke) from the Estonian Pediatric Stroke Database were reviewed. Children with presumed perinatal stroke were born at term in 95% of the cases and had had no risk factors during pregnancy in 43% of the cases. Children with periventricular venous infarction were born significantly more often...
Source: Journal of Child Neurology - March 16, 2016 Category: Neurology Authors: Ilves, P., Laugesaar, R., Loorits, D., Kolk, A., Tomberg, T., Loo, S., Talvik, I., Kahre, T., Talvik, T. Tags: Original Articles Source Type: research
Analysis of Altered Micro RNA Expression Profiles in Focal Cortical Dysplasia IIB
In this study, to investigate the molecular etiology of focal cortical dysplasia type IIB, the authors performed micro ribonucleic acid (RNA) microarray on surgical specimens from 5 children (2 female and 3 male, mean age was 73.4 months, range 50-112 months) diagnosed of focal cortical dysplasia type IIB and matched normal tissue adjacent to the lesion. In all, 24 micro RNAs were differentially expressed in focal cortical dysplasia type IIB, and the microarray results were validated using quantitative real-time polymerase chain reaction (PCR). Then the putative target genes of the differentially expressed micro RNAs were ...
Source: Journal of Child Neurology - March 16, 2016 Category: Neurology Authors: Li, L., Liu, C.-Q., Li, T.-F., Guan, Y.-G., Zhou, J., Qi, X.-L., Yang, Y.-T., Deng, J.-H., Xu, Z.-Q. D., Luan, G.-M. Tags: Original Articles Source Type: research
The Effects of the Severity of Periventricular Leukomalacia on the Neuropsychological Outcomes of Preterm Children
This study investigates the developmental outcomes of preterm children according to severity of periventricular leukomalacia. One hundred preterm children with periventricular leukomalacia evident on brain magnetic resonance imaging and who had undergone neuropsychologic evaluation were selected. Intellectual disability was noted in 27.8% of the children with mild periventricular leukomalacia, 53.2% with moderate periventricular leukomalacia, and 77.1% with severe periventricular leukomalacia. The rates of major neurodevelopmental impairments such as cerebral palsy or intellectual disability were related to the severity of...
Source: Journal of Child Neurology - March 16, 2016 Category: Neurology Authors: Choi, J. Y., Rha, D.-w., Park, E. S. Tags: Original Articles Source Type: research
Validity of the Child Facial Coding System for the Assessment of Acute Pain in Children With Cerebral Palsy
The purpose of the current study was to examine the concurrent and discriminant validity of the Child Facial Coding System for children with cerebral palsy. Eighty-five children (mean = 8.35 years, SD = 4.72 years) were videotaped during a passive joint stretch with their physiotherapist and during 3 time segments: baseline, passive joint stretch, and recovery. Children’s pain responses were rated from videotape using the Numerical Rating Scale and Child Facial Coding System. Results indicated that Child Facial Coding System scores during the passive joint stretch significantly correlated with Numerical Rating Scale ...
Source: Journal of Child Neurology - March 16, 2016 Category: Neurology Authors: Hadden, K. L., LeFort, S., OBrien, M., Coyte, P. C., Guerriere, D. N. Tags: Original Articles Source Type: research
