Skin Ulcers and Mortality Among Adolescents and Young Adults With Spina Bifida in South Carolina During 2000-2010
This study showed that age at which individuals first had a skin ulcer was associated with mortality. (Source: Journal of Child Neurology)
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Cai, B., McDermott, S., Wang, Y., Royer, J. A., Mann, J. R., Hardin, J. W., Ozturk, O., Ouyang, L. Tags: Original Articles Source Type: research
Age at Referral of Children for Initial Diagnosis of Cerebral Palsy and Rehabilitation: Current Practices
Conclusions:
Primary care providers generated a minority of referrals, of concern given their role in developmental surveillance. Remarkably high variability suggests knowledge of cerebral palsy attributes varies widely among service providers. Half of children with cerebral palsy do not have a complicated birth history; subsequently, referrals for diagnosis and management are often delayed. New strategies are needed to optimize prompt referral by primary care providers. (Source: Journal of Child Neurology)
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Hubermann, L., Boychuck, Z., Shevell, M., Majnemer, A. Tags: Original Articles Source Type: research
Outcomes of Botulinum Toxin Type A Injection Followed by Rehabilitation in Cases of Cerebral Palsy With Upper Extremity Involvement
We evaluated the efficiency of botulinum toxin type A injection followed by a rehabilitation program including individual therapy, group therapy, and occupational therapy in cases of cerebral palsy with upper extremity involvement. A total of 29 injections were performed on 25 patients, and the patients were placed on rehabilitation program. At 3-month and 6-month assessments, there was a significant improvement in lateral grip strength, 9 Hole Peg test, Upper Limb Physician’s Rating Scale and pediatric functional independence measure total scores. There were significant decreases in active range of motion in elbow e...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Karaca, B., Ünlü, E., Köse, G., Gönen, E., Cakcı, A. Tags: Original Articles Source Type: research
Detection of Cerebral Vasculopathy by Transcranial Doppler in Children With Neurofibromatosis Type 1
Neurofibromatosis type 1 is characterized by nerve sheath neurofibromas associated with a number of additional clinical features, including cerebrovascular disease. The aim of this study was to use transcranial Doppler as a screening method for identifying cerebral vasculopathy in children with neurofibromatosis type 1. Forty children with neurofibromatosis type 1, aged 5 to 18 years old, were examined by transcranial Doppler. Patients presenting with hemodynamic features of arterial stenosis/occlusion on transcranial Doppler underwent magnetic resonance angiography to confirm the findings. Magnetic resonance angiography w...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Paschoal, J. K. S. F., Paschoal, F. M., de Lima, F. T., Pinho, R. S., Vilanova, L. C. P., Bor-Seng-Shu, E., Masruha, M. R. Tags: Original Articles Source Type: research
Role of Autoantibodies to N-Methyl-D-Aspartate (NMDA) Receptor in Relapsing Herpes Simplex Encephalitis: A Retrospective, One-Center Experience
Post–herpes simplex virus encephalitis relapses have been recently associated with autoimmunity driven by autoantibodies against N-methyl-d-aspartate (NMDA) receptors. Because it offers different treatment options, determination of this condition is important. Between 2011 and 2014, 7 children with proven diagnosis of herpes simplex virus encephalitis were identified in a university hospital of Istanbul. Two patients had neurologic relapse characterized mainly by movement disorders 2 to 3 weeks after initial encephalitis. The first patient received a second 14 days of acyclovir treatment together with antiepileptic d...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Sutcu, M., Akturk, H., Somer, A., Tatli, B., Torun, S. H., Yıldız, E. P., Sık, G., Citak, A., Agacfidan, A., Salman, N. Tags: Original Articles Source Type: research
Outcome of Early Juvenile Onset Metachromatic Leukodystrophy After Unrelated Cord Blood Transplantation: A Case Series and Review of the Literature
The purpose of this study was to determine whether transplantation of umbilical cord blood from unrelated donors before the development of symptoms could halt the progression of early juvenile onset cases of MLD in whom the disease was diagnosed based on the family history. Three asymptomatic children (aged 2 years 4 months, 2 years 8 months and 5 years 5 months, two of whom were sisters) underwent unrelated umbilical cord blood transplantation (UCBT) and two untreated symptomatic siblings were included in the study. In 14-year and 6-year follow-ups after transplantation, clinical examination, ARSA enzyme levels, neurophys...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Chen, X., Gill, D., Shaw, P., Ouvrier, R., Troedson, C. Tags: Original Articles Source Type: research
Survey of the Child Neurology Program Coordinator Association: Workforce Issues and Readiness for the Next Accreditation System
In preparation for the implementation of the Next Accreditation System in Child Neurology, the authors organized the first meeting of child neurology program coordinators in October 2014. A workforce and program-readiness survey was conducted initially. Coordinator job titles varied widely. Most respondents (65%) managed 1 or more fellowships plus child neurology residency. Most had worked in graduate medical education less than 5 years (53%), with no career path (88%), supervised by someone without graduate medical education experience (85%), in divisions where faculty knowledge was judged inadequate (72%). A small propor...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Feist, T. B., Campbell, J. L., LaBare, J. A., Gilbert, D. L. Tags: Original Articles Source Type: research
Continuous Video Electroencephalographic (EEG) Monitoring for Electrographic Seizure Diagnosis in Neonates: A Single-Center Study
The objective of this study was to determine the diagnostic yield of continuous video electroencephalographic (EEG) monitoring in critically ill neonates in the setting of a novel, university-based Neonatal Neurocritical Care Service. Patient demographic characteristics, indication for seizure monitoring, and presence of electrographic seizures were obtained by chart review. Among 595 patients cared for by the Neonatal Neurocritical Care Service, 400 (67%) received continuous video EEG. The median duration of continuous video EEG monitoring was 49 (interquartile range = 22-87) hours. Electrographic seizures were captured i...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Wietstock, S. O., Bonifacio, S. L., Sullivan, J. E., Nash, K. B., Glass, H. C. Tags: Original Articles Source Type: research
Case Series: Fractional Anisotropy Profiles of the Cerebellar Peduncles in Adolescents Born Preterm With Ventricular Dilation
This case series assesses white matter microstructure of the cerebellar peduncles in 4 adolescents born preterm with enlarged ventricles and reduced white matter volume in the cerebrum but no apparent injury to the cerebellum. Subjects (ages 12-17 years, gestational age 26-32 weeks, birth weight 825-2211 g) were compared to a normative sample of 19 full-term controls (9-17 years, mean gestational age 39 weeks, mean birth weight 3154 g). Tract profiles for each of the cerebellar peduncles were generated by calculating fractional anisotropy at 30 points along the central portion of each tract. One or more case subjects exhib...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Travis, K. E., Leitner, Y., Ben-Shachar, M., Yeom, K. W., Feldman, H. M. Tags: Original Articles Source Type: research
Two Hundred Thirty-Six Children With Developmental Hydrocephalus: Causes and Clinical Consequences
Few systematic assessments of developmental forms of hydrocephalus exist. We reviewed magnetic resonance images (MRIs) and clinical records of patients with infancy-onset hydrocephalus. Among 411 infants, 236 had hydrocephalus with no recognizable extrinsic cause. These children were assigned to 1 of 5 subtypes and compared on the basis of clinical characteristics and developmental and surgical outcomes. At an average age of 5.3 years, 72% of children were walking independently and 87% could eat by mouth; in addition, 18% had epilepsy. Distinct patterns of associated malformations and syndromes were observed within each su...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Tully, H. M., Ishak, G. E., Rue, T. C., Dempsey, J. C., Browd, S. R., Millen, K. J., Doherty, D., Dobyns, W. B. Tags: Original Articles Source Type: research
Regional Microstructural and Volumetric Magnetic Resonance Imaging (MRI) Abnormalities in the Corpus Callosum of Neonates With Congenital Heart Defect Undergoing Cardiac Surgery
The purpose of the study is to investigate the structural development of the corpus callosum in term neonates with congenital heart defect before and after surgery using diffusion tensor imaging and 3-dimensional T1-weighted magnetic resonance imaging (MRI). We compared parallel and radial diffusions, apparent diffusion coefficient (ADC), fractional anisotropy, and volume of 5 substructures of the corpus callosum: genu, rostral body, body, isthmus, and splenium. Compared to healthy controls, we found a significantly lower volume of the splenium and total corpus callosum and a higher radial diffusion and lower fractional an...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Hagmann, C., Singer, J., Latal, B., Knirsch, W., Makki, M. Tags: Original Articles Source Type: research
Personality Profile of Male Adolescents With Tourette Syndrome: A Controlled Study
Tourette syndrome is a neurodevelopmental disorder characterized by multiple tics and commonly associated with behavioral problems, especially obsessive-compulsive disorder and attention-deficit hyperactivity disorder (ADHD). The presence of specific personality traits has been documented in adult clinical populations with Tourette syndrome but has been underresearched in younger patients. We assessed the personality profiles of 17 male adolescents with Tourette syndrome and 51 age- and gender-matched healthy controls using the Minnesota Multiphasic Personality Inventory–Adolescent version, along with a standardized ...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Balottin, L., Selvini, C., Luoni, C., Mannarini, S., Chiappedi, M., Seri, S., Termine, C., Cavanna, A. E. Tags: Original Articles Source Type: research
The Clinical Implications of Todd Paralysis in Children With Benign Rolandic Epilepsy
The aim of this study was to describe the clinical and electroencephalographic (EEG) findings of postictal Todd paralysis in benign rolandic epilepsy of childhood and find out the possible correlation with migraine. Based on International Headache Society pediatric migraine criteria, patients were investigated for migraine, and 12 of the 108 patients with benign rolandic epilepsy (6 girls and 6 boys, 11.1%) were found to have postictal Todd paralysis. Ten of these 12 patients (83.3%) had pediatric migraine based on the diagnostic criteria. We showed comorbidity of migraine and benign rolandic epilepsy with postictal Todd p...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Dai, A. I., Demiryürek, S. Tags: Original Articles Source Type: research
Is Celiac Disease an Etiological Factor in Children with Nonsyndromic Intellectual Disability?
To determine the prevalence of celiac disease in children and adolescents with nonsyndromic intellectual disability, we investigated serum levels of tissue transglutaminase antibody and total IgA from 232 children with nonsyndromic intellectual disability and in a healthy control group of 239 children. Study participants who were positive for tissue transglutaminase antibody underwent a duodenal biopsy. A total of 3 patients in the nonsyndromic intellectual disability group (5.45%) and 1 in the control group (0.41%) had positive serum tissue transglutaminase antibody (P > .05). Duodenal biopsy confirmed celiac disease i...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Sezer, T., Balcı, O., Özcay, F., Bayraktar, N., Alehan, F. Tags: Original Articles Source Type: research
Study of Posterior Reversible Encephalopathy Syndrome in Children With Acute Lymphoblastic Leukemia After Induction Chemotherapy
Increasing occurrence of posterior reversible encephalopathy syndrome has been reported in children with acute lymphoblastic leukemia. However, the etiology of posterior reversible encephalopathy syndrome is not clear. To study the possible pathogenetic mechanisms and treatment of this complication, we reported 11 cases of pediatric acute lymphoblastic leukemia who developed posterior reversible encephalopathy syndrome after induction chemotherapy. After appropriate treatment, the clinical symptoms of posterior reversible encephalopathy syndrome in most cases disappeared even though induction chemotherapy continued. During...
Source: Journal of Child Neurology - February 9, 2016 Category: Neurology Authors: Tang, J.-H., Tian, J.-M., Sheng, M., Hu, S.-Y., Li, Y., Zhang, L.-Y., Gu, Q., Wang, Q. Tags: Original Articles Source Type: research
