Prognostic Significance of P2RY8 ‐CRLF2 and CRLF2 Overexpression May Vary Across Risk Subgroups of Childhood B‐cell Acute Lymphoblastic Leukemia
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - September 15, 2016 Category: Cancer & Oncology Authors: Hu Dou, Xi Chen, Yi Huang, Yongchun Su, Ling Lu, Jie Yu, Yibing Yin, Liming Bao Tags: Research Article Source Type: research
Table of Content Volume 55, Number 11, November 2016
(Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - September 11, 2016 Category: Cancer & Oncology Tags: Issue Information ‐ TOC Source Type: research
MicroRNAs Role as Potential Biomarkers and Key Regulators in Melanoma
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - August 26, 2016 Category: Cancer & Oncology Authors: Chiara Varamo, Marcella Occelli, Daniela Vivenza, Marco Merlano, Cristiana Lo Nigro Tags: Review Article Source Type: research
Expanding the molecular signature of ossifying fibromyxoid tumors with two novel gene fusions: CREBBP ‐BCORL1 and KDM2A‐WWTR1
Ossifying fibromyxoid tumor (OFMT) is an uncommon mesenchymal neoplasm of uncertain differentiation and intermediate malignant potential. Recurrent gene fusions involving either PHF1 or BCOR have been found in 85% of OFMT, including typical and malignant examples. As a subset of OFMT still lack known genetic abnormalities, we identified two OFMTs negative for PHF1 and BCOR rearrangements, which were subjected to transcriptome analysis for fusion discovery. The RNA sequencing found a novel CREBBP‐BCORL1 fusion candidate in an axillary mass of a 51 year‐old male and a KDM2A‐WWTR1 in a thigh mass of a 36 year‐old male...
Source: Genes, Chromosomes and Cancer - August 25, 2016 Category: Cancer & Oncology Authors: Yu ‐Chien Kao, Yun‐Shao Sung, Lei Zhang, Chun‐Liang Chen, Shih‐Chiang Huang, Cristina R. Antonescu Tags: Research Article Source Type: research
Parental Origin of the Deletion del(20)(q) in Shwachman ‐Diamond Patients and Loss of the Paternally Derived Allele of the Imprinted L3MBTL1 Gene
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - August 24, 2016 Category: Cancer & Oncology Authors: Lucia Nacci, Roberto Valli, Rita Maria Pinto, Marco Zecca, Marco Cipolli, Jacopo Morini, Simone Cesaro, Emanuela Boveri, Vittorio Rosti, Paola Corti, Maura Ambroni, Francesco Pasquali, Cesare Danesino, Emanuela Maserati, Antonella Minelli Tags: Research Article Source Type: research
Expanding the Molecular Signature of Ossifying Fibromyxoid Tumors with 2 Novel Gene Fusions: CREBBP ‐BCORL1 and KDM2A‐WWTR1
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - August 19, 2016 Category: Cancer & Oncology Authors: Yu ‐Chien Kao, Yun‐Shao Sung, Lei Zhang, Chun‐Liang Chen, Shih‐Chiang Huang, Cristina R. Antonescu Tags: Research Article Source Type: research
Heterogeneity of MYCN amplification in neuroblastoma at diagnosis, treatment, relapse, and metastasis
Amplification of the MYCN gene in neuroblastoma is associated with a poor prognosis and is considered to remain unchanged in post‐treatment specimens and metastases. While heterogeneity of MYCN copy number in tumor cells has been reported, serial samples have only been studied in a limited way, and the biologic relevance of this finding is not well understood. We used in situ hybridization on paraffin sections of 102 specimens from 30 patients with MYCN‐amplified neuroblastoma to determine MYCN copy number in the primary tumor, pre‐ and post‐treatment, and in metastatic samples. Nineteen cases (63%) showed diffuse ...
Source: Genes, Chromosomes and Cancer - August 17, 2016 Category: Cancer & Oncology Authors: Paula Marrano, Meredith S. Irwin, Paul S. Thorner Tags: Research Article Source Type: research
FGFR3 preferentially colocalizes with IGH in the interphase nucleus of multiple myeloma patient B ‐cells when FGFR3 is located outside of CT4
Many B‐cell malignancies are characterized by chromosomal translocations involving IGH and a proto‐oncogene. For translocations to occur, spatial proximity of translocation‐prone genes is necessary. Currently, it is not known how such genes are brought into proximity with one another. Although decondensed chromosomes occupy definitive, non‐random spaces in the interphase nucleus known as chromosome territories (CTs), chromatin at the edges of CTs can intermingle, and specific genomic regions from some chromosomes have been shown to “loop out” of their respective CTs. This extra‐territorial positioning of spec...
Source: Genes, Chromosomes and Cancer - August 10, 2016 Category: Cancer & Oncology Authors: Lorri D. Martin, Jana Harizanova, Sabine Mai, Andrew R. Belch, Linda M. Pilarski Tags: Research Article Source Type: research
Table of Content Volume 55, Number 10, October 2016
(Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - August 8, 2016 Category: Cancer & Oncology Tags: Issue Information ‐ TOC Source Type: research
Exhaled Breath Condensate as a Source of Biomarkers for Lung Carcinomas. A Focus on Genetic and Epigenetic Markers – A Mini‐Review
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - August 2, 2016 Category: Cancer & Oncology Authors: Omar Youssef, Virinder Kaur Sarhadi, Gemma Armengol, P äivi Piirilä, Aija Knuuttila, Sakari Knuutila Tags: Review Article Source Type: research
Small cell undifferentiated (SCUD) hepatoblastomas: All malignant rhabdoid tumors?
In conclusion, we postulate that SCUD hepatoblastoma is not a hepatoblastoma but represents a malignant rhabdoid tumor of the liver. © 2016 Wiley Periodicals, Inc. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - July 28, 2016 Category: Cancer & Oncology Authors: Christian Vokuhl, Florian Oyen, Beate H äberle, Dietrich von Schweinitz, Reinhard Schneppenheim, Ivo Leuschner Tags: Research Article Source Type: research
Heterogeneity of MYCN Amplification in Neuroblastoma at Diagnosis, Treatment, Relapse and Metastasis
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - July 28, 2016 Category: Cancer & Oncology Authors: Paula Marrano, Meredith S. Irwin, Paul S. Thorner Tags: Research Article Source Type: research
Characterizing Genetic Transitions of Copy Number Alterations and Allelic Imbalances in Oral Tongue Carcinoma Metastasis
This study indicates that additional genetic changes, such as 20q11.2 gain, which encodes the E2F1 gene, can be acquired through clonal evolution, and may be required for the metastatic process. This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - July 27, 2016 Category: Cancer & Oncology Authors: Takuma Morita, Narikazu Uzawa, Kaoru Mogushi, Jun Sumino, Chieko Michikawa, Ken ‐Ichiro Takahashi, Kunihiro Myo, Toshiyuki Izumo, Kiyoshi Harada Tags: Research Article Source Type: research
Genomic Studies of Multiple Myeloma Reveal an Association between X Chromosome Alterations and Genomic Profile Complexity
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - July 26, 2016 Category: Cancer & Oncology Authors: Tiberio Sticca, Jean ‐Hubert Caberg, Stephane Wenric, Christophe Poulet, Christian Herens, Mauricette Jamar, Claire Josse, Sonia El Guendi, Stéphanie Max, Yves Beguin, André Gothot, Jo Caers, Vincent Bours Tags: Research Article Source Type: research
Tubular, Lactating, and Ductal Adenomas Are Devoid of MED12 Exon2 Mutations, and Ductal Adenomas Show Recurrent Mutations in GNAS and the PI3K‐AKT pathway
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - July 21, 2016 Category: Cancer & Oncology Authors: Anna‐Lena Volckmar, Jonas Leichsenring, Christa Flechtenmacher, Nicole Pfarr, Udo Siebolts, Martina Kirchner, Jan Budczies, Michael Bockmayr, Kathrin Ridinger, Katja Lorenz, Esther Herpel, Aurelia Noske, Wilko Weichert, Frederick Klauschen, Peter Schirm Tags: Research Article Source Type: research
