Soft tissue angiofibroma – clinicopathologic, immunohistochemical and molecular analysis of 14 cases
In conclusion, the AHRR‐NCOA2 fusion is a frequent finding in soft tissue angiofibroma, while GTF2I‐NCOA2 seems to be a rare genetic event. For the first time, we report a GAB1‐ABL1 fusion in a soft tissue angiofibroma of a child. Nuclear expression of NCOA2 is not discriminating when compared with other spindle cell neoplasms. This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - June 22, 2017 Category: Cancer & Oncology Authors: Elise M Bekers, Patricia JTA Groenen, Marian AJ Verdijk, Winny L Raaijmakers ‐van Geloof, Paul Roepman, Robert Vink, Nathalie D B Gilhuijs, Joost M van Gorp, Judith VMG Bovée, David H Creytens, Adrienne M Flanagan, Albert JH Suurmeijer, Thomas Mentzel, Tags: Research Article Source Type: research
Relationship between pancreatic intraepithelial neoplasias, pancreatic ductal adenocarcinomas, and single nucleotide polymorphisms in autopsied elderly patients
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - June 22, 2017 Category: Cancer & Oncology Authors: Yoko Matsuda, Masashi Tanaka, Motoji Sawabe, Seijiro Mori, Masaaki Muramatsu, Makiko Naka Mieno, Toru Furukawa, Tomio Arai Tags: Research Article Source Type: research
Mutational Profiles of Brenner Tumors show Distinctive Features Uncoupling Urothelial Carcinomas and Ovarian Carcinoma with Transitional Cell Histology
In conclusion, our study highlights distinct genetic features of BTs, and detection of the triplet phenotype MDM2 amplification/TP53 wt/TERT wt may aid diagnosis of malignant BT in difficult cases. Moreover, selected genetic lesions may be clinically exploitable in a metastatic setting. This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - June 22, 2017 Category: Cancer & Oncology Authors: Nicole Pfarr, Silvia Darb ‐Esfahani, Jonas Leichsenring, Eliane Taube, Melanie Boxberg, Ioana Braicu, Moritz Jesinghaus, Roland Penzel, Volker Endris, Aurelia Noske, Wilko Weichert, Peter Schirmacher, Carsten Denkert, Albrecht Stenzinger Tags: Research Article Source Type: research
Table of Content Volume 56, Number 8, August 2017
(Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - June 12, 2017 Category: Cancer & Oncology Tags: ISSUE INFORMATION ‐ TOC Source Type: research
Impact of MLH1 expression on tumor evolution after curative surgical tumor resection in a murine orthotopic xenograft model for human MSI colon cancer
Abstract
Colorectal cancers (CRCs) displaying microsatellite instability (MSI) most often result from MLH1 deficiency. The aim of this study was to assess the impact of MLH1 expression per se on tumor evolution after curative surgical resection using a xenograft tumor model. Transplantable tumors established with the human MLH1‐deficient HCT116 cell line and its MLH1‐complemented isogenic clone, mlh1‐3, were implanted onto the caecum of NOD/SCID mice. Curative surgical resection was performed at day 10 in half of the animals. The HCT116‐derived tumors were more voluminous compared to the mlh1‐3 ones (P = .001). L...
Source: Genes, Chromosomes and Cancer - June 12, 2017 Category: Cancer & Oncology Authors: Katy Meunier, Marianne Ferron, Claire Calmel, Jean ‐François Fléjou, Marc Pocard, Françoise Praz Tags: RESEARCH ARTICLE Source Type: research
Genomic and metabolic characterization of a chromophobe renal cell carcinoma cell line model (UOK276)
This study characterizes a novel ChRCC‐derived cell line model, UOK276. A large ChRCC tumor with regions of sarcomatoid differentiation was used to establish a spontaneously immortal cell line, UOK276. UOK276 was evaluated for chromosomal, mutational and metabolic aberrations. The UOK276 cell line is hyper‐diploid with a modal number of 49 chromosomes per cell, and evidence of copy‐neutral loss of heterozygosity, as opposed to the classic pattern of ChRCC chromosomal losses. UOK276 demonstrated a TP53 missense mutation, expressed mutant TP53 protein, and responded to treatment with a small molecule therapeutic agent,...
Source: Genes, Chromosomes and Cancer - June 9, 2017 Category: Cancer & Oncology Authors: Youfeng Yang, Cathy D. Vocke, Christopher J. Ricketts, Darmood Wei, Hesed M. Padilla ‐Nash, Martin Lang, Carole Sourbier, J. Keith Killian, Shawna L. Boyle, Robert Worrell, Paul S. Meltzer, Thomas Ried, Maria J. Merino, Adam R. Metwalli, W. Marston Line Tags: Research Article Source Type: research
Copy number alterations determined by single nucleotide polymorphism array testing in the clinical laboratory are indicative of gene fusions in pediatric cancer patients
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - June 9, 2017 Category: Cancer & Oncology Authors: Tracy M. Busse, Jacquelyn J. Roth, Donna Wilmoth, Luanne Wainwright, Laura Tooke, Jaclyn A. Biegel Tags: Research Article Source Type: research
Comparison of different methods for telomere length measurement in whole blood and blood cell subsets: Recommendations for telomere length measurement in hematological diseases
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - June 8, 2017 Category: Cancer & Oncology Authors: Yvonne Lisa Behrens, Kathrin Thomay, Maike Hagedorn, Juliane Ebersold, Lea Henrich, Rainer Nustede, Brigitte Schlegelberger, Gudrun G öhring Tags: Research Article Source Type: research
A novel EWS ‐CREB3L3 gene fusion in a mesenteric sclerosing epithelioid fibrosarcoma
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - June 1, 2017 Category: Cancer & Oncology Authors: Barbara Dewaele, Louis Libbrecht, Gabriel Levy, Benedicte Brichard, Vanessa Vanspauwen, Raf Sciot, Maria Debiec ‐Rychter Tags: Research Article Source Type: research
Occurrence of BAP1 germline mutations in cutaneous melanocytic tumors with loss of BAP1 ‐expression: a pilot study
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - May 31, 2017 Category: Cancer & Oncology Authors: Odile Cabaret, Emilie Perron, Brigitte Bressac ‐ de Paillerets, Nadem Soufir, Arnaud de la Fouchardière Tags: Research Article Source Type: research
Highly recurrent H3F3A mutations with additional epigenetic regulator alterations in giant cell tumor of bone
In conclusion, we confirmed that H3F3A is the most frequently mutated GCTB driver gene, and that H3F3A mutations are not present in atypical GCTBs. Sanger sequencing was much less sensitive than targeted NGS for detecting H3F3A mutations in FFPE samples. This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - May 26, 2017 Category: Cancer & Oncology Authors: Koichi Ogura, Fumie Hosoda, Hiromi Nakamura, Natsuko Hama, Yasushi Totoki, Akihiko Yoshida, Shoko Ohashi, Hirofumi Rokutan, Erina Takai, Shinichi Yachida, Akira Kawai, Sakae Tanaka, Tatsuhiro Shibata Tags: Research Article Source Type: research
Impact of MLH1 expression on tumour evolution after curative surgical tumour resection in a murine orthotopic xenograft model for human MSI colon cancer
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - May 17, 2017 Category: Cancer & Oncology Authors: Katy Meunier, Marianne Ferron, Claire Calmel, Jean ‐François Fléjou, Marc Pocard, Françoise Praz Tags: Research Article Source Type: research
TFG ‐MET fusion in an infantile spindle cell sarcoma with neural features
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - May 16, 2017 Category: Cancer & Oncology Authors: Uta Flucke, Max M van Noesel, Marc Wijnen, Lei Zhang, Chun ‐Liang Chen, Yun‐Shao Sung, Cristina R Antonescu Tags: Research Article Source Type: research
KIF11 silencing and inhibition induces chromosome instability that may contribute to cancer
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - May 16, 2017 Category: Cancer & Oncology Authors: Yasamin Asbaghi, Laura L. Thompson, Zelda Lichtensztejn, Kirk J. McManus Tags: Research Article Source Type: research
Table of Content Volume 56, Number 7, July 2017
(Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - May 11, 2017 Category: Cancer & Oncology Tags: ISSUE INFORMATION ‐ TOC Source Type: research
