Truncating and Missense PPM1D Mutations in Early‐Onset and/or Familial/Hereditary Prostate Cancer Patients
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - July 12, 2016 Category: Cancer & Oncology Authors: Marta Cardoso, Paula Paulo, Sofia Maia, Manuel R. Teixeira Tags: Research Article Source Type: research
Molecular bases of aberrant miR ‐182 expression in ovarian cancer
The molecular bases of miR‐182 deregulation in epithelial ovarian cancers (EOCs) remain unknown and its diagnostic or prognostic role in EOCs is still unclear. We performed miR‐182 expression analysis using a microarray approach and real‐time PCR (qPCR). We also used array comparative genomic hybridization and methylated DNA immunoprecipitation to study copy number changes and methylation aberrations within coding locus/promoter sequences of miR‐182 in EOC tissues, respectively. We have found that miR‐182 expression is significantly increased in EOC (P < 0.00001) and that higher miR‐182 expression in EOC...
Source: Genes, Chromosomes and Cancer - July 11, 2016 Category: Cancer & Oncology Authors: Barbara Marzec ‐Kotarska, Marek Cybulski, Józef Czesław Kotarski, Anna Ronowicz, Rafał Tarkowski, Grzegorz Polak, Halina Antosz, Arkadiusz Piotrowski, Jan Kotarski Tags: Research Article Source Type: research
VOLIN and KJON —Two novel hyperdiploid myeloma cell lines
Multiple myeloma can be divided into two distinct genetic subgroups: hyperdiploid (HRD) or nonhyperdiploid (NHRD) myeloma. Myeloma cell lines are important tools to study myeloma cell biology and are commonly used for preclinical screening and testing of new drugs. With few exceptions human myeloma cell lines are derived from NHRD patients, even though about half of the patients have HRD myeloma. Thus, there is a need for cell lines of HRD origin to enable more representative preclinical studies. Here, we present two novel myeloma cell lines, VOLIN and KJON. Both of them were derived from patients with HRD disease and shar...
Source: Genes, Chromosomes and Cancer - July 11, 2016 Category: Cancer & Oncology Authors: Thea Kristin V åtsveen, Magne Børset, Aida Dikic, Erming Tian, Francesca Micci, Ana H. B. Lid, Leonardo A. Meza‐Zepeda, Eivind Coward, Anders Waage, Anders Sundan, W. Michael Kuehl, Toril Holien Tags: Research Article Source Type: research
Novel IGH and MYC Translocation Partners in Diffuse Large B ‐Cell Lymphomas
Chromosomal translocations involving an immunoglobulin (IG) locus and a proto‐oncogene play a major role in diffuse large B‐cell lymphoma (DLBCL) pathogenesis. Recurrent IG translocation partners in DLBCL are the BCL6, BCL2, and MYC genes, but other rare translocation partners are also known. We studied 20 DLBCL with fluorescence in situ hybridization‐based evidence for IG heavy chain (IGH) locus‐associated translocations not involving BCL6, BCL2, MALT1, or MYC by long distance inverse PCR to identify the translocation partners. Moreover, we studied eight DLBCL with MYC translocations not involving IG or known non...
Source: Genes, Chromosomes and Cancer - July 11, 2016 Category: Cancer & Oncology Authors: Claudia Otto, Ren é Scholtysik, Roland Schmitz, Markus Kreuz, Claudia Becher, Michael Hummel, Andreas Rosenwald, Lorenz Trümper, Wolfram Klapper, Reiner Siebert, Ralf Küppers, Tags: Research Article Source Type: research
Truncating and Missense PPM1D Mutations in Early ‐Onset and/or Familial/Hereditary Prostate Cancer Patients
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - July 11, 2016 Category: Cancer & Oncology Authors: Marta Cardoso, Paula Paulo, Sofia Maia, Manuel R. Teixeira Tags: Research Article Source Type: research
VOLIN and KJON—Two novel hyperdiploid myeloma cell lines
Multiple myeloma can be divided into two distinct genetic subgroups: hyperdiploid (HRD) or nonhyperdiploid (NHRD) myeloma. Myeloma cell lines are important tools to study myeloma cell biology and are commonly used for preclinical screening and testing of new drugs. With few exceptions human myeloma cell lines are derived from NHRD patients, even though about half of the patients have HRD myeloma. Thus, there is a need for cell lines of HRD origin to enable more representative preclinical studies. Here, we present two novel myeloma cell lines, VOLIN and KJON. Both of them were derived from patients with HRD disease and shar...
Source: Genes, Chromosomes and Cancer - July 11, 2016 Category: Cancer & Oncology Authors: Thea Kristin Våtsveen, Magne Børset, Aida Dikic, Erming Tian, Francesca Micci, Ana H. B. Lid, Leonardo A. Meza‐Zepeda, Eivind Coward, Anders Waage, Anders Sundan, W. Michael Kuehl, Toril Holien Tags: Research Article Source Type: research
Novel IGH and MYC Translocation Partners in Diffuse Large B‐Cell Lymphomas
Chromosomal translocations involving an immunoglobulin (IG) locus and a proto‐oncogene play a major role in diffuse large B‐cell lymphoma (DLBCL) pathogenesis. Recurrent IG translocation partners in DLBCL are the BCL6, BCL2, and MYC genes, but other rare translocation partners are also known. We studied 20 DLBCL with fluorescence in situ hybridization‐based evidence for IG heavy chain (IGH) locus‐associated translocations not involving BCL6, BCL2, MALT1, or MYC by long distance inverse PCR to identify the translocation partners. Moreover, we studied eight DLBCL with MYC translocations not involving IG or known non...
Source: Genes, Chromosomes and Cancer - July 11, 2016 Category: Cancer & Oncology Authors: Claudia Otto, René Scholtysik, Roland Schmitz, Markus Kreuz, Claudia Becher, Michael Hummel, Andreas Rosenwald, Lorenz Trümper, Wolfram Klapper, Reiner Siebert, Ralf Küppers, Tags: Research Article Source Type: research
Novel Fusion Genes and Chimeric Transcripts in Ependymal Tumors
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - July 11, 2016 Category: Cancer & Oncology Authors: Thale Kristin Olsen, Ioannis Panagopoulos, Ludmila Gorunova, Francesca Micci, Kristin Andersen, Hege Kilen Andersen, Torstein R. Meling, Bernt Due‐Tønnessen, David Scheie, Sverre Heim, Petter Brandal Tags: Research Article Source Type: research
Table of Content Volume 55, Number 9, September 2016
(Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - July 10, 2016 Category: Cancer & Oncology Tags: Issue Information ‐ TOC Source Type: research
Different prognostic roles of tumor suppressor gene BAP1 in cancer: A systematic review with meta ‐analysis
In conclusion, on the basis of our meta‐analysis, we have demonstrated a peculiar role of BAP1 in influencing the prognosis in cancer. Thus, BAP1 could be considered as an important potential target for personalized medicine. © 2016 Wiley Periodicals, Inc. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - July 6, 2016 Category: Cancer & Oncology Authors: Claudio Luchini, Nicola Veronese, Shinichi Yachida, Liang Cheng, Alessia Nottegar, Brendon Stubbs, Marco Solmi, Paola Capelli, Antonio Pea, Mattia Barbareschi, Matteo Fassan, Laura D Wood, Aldo Scarpa Tags: Review Article Source Type: research
Expanding the spectrum of ALK ‐rearranged renal cell carcinomas in children: Identification of a novel HOOK1‐ALK fusion transcript
(Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - July 6, 2016 Category: Cancer & Oncology Authors: Mariana M. Cajaiba, Lawrence J. Jennings, David George, Elizabeth J. Perlman Tags: Letter to the Editors Source Type: research
BRCA1 ‐2 diagnostic workflow from next‐generation sequencing technologies to variant identification and final report
The BRCA1‐BRCA2 genes predispose to hereditary breast and ovarian cancer, and the germline and mutational status of these genes defines a target population that can benefit from PARP inhibitor treatments. To respond to the increasing number of BRCA1‐BRCA2 tests, it is necessary to shift to high‐throughput technologies that are reliable and less time consuming. Different methodological platforms are dedicated to this purpose with different approaches and algorithms for analysis. Our aim was to set up a cost‐effective and low time‐consuming BRCA1‐BRCA2 mutation detection workflow using the Ion Torrent PGM technol...
Source: Genes, Chromosomes and Cancer - July 3, 2016 Category: Cancer & Oncology Authors: Brunella Pilato, Rosamaria Pinto, Simona De Summa, Daniela Petriella, Rosanna Lacalamita, Katia Danza, Angelo Paradiso, Stefania Tommasi Tags: Research Article Source Type: research
BRCA1‐2 diagnostic workflow from next‐generation sequencing technologies to variant identification and final report
The BRCA1‐BRCA2 genes predispose to hereditary breast and ovarian cancer, and the germline and mutational status of these genes defines a target population that can benefit from PARP inhibitor treatments. To respond to the increasing number of BRCA1‐BRCA2 tests, it is necessary to shift to high‐throughput technologies that are reliable and less time consuming. Different methodological platforms are dedicated to this purpose with different approaches and algorithms for analysis. Our aim was to set up a cost‐effective and low time‐consuming BRCA1‐BRCA2 mutation detection workflow using the Ion Torrent PGM technol...
Source: Genes, Chromosomes and Cancer - July 3, 2016 Category: Cancer & Oncology Authors: Brunella Pilato, Rosamaria Pinto, Simona De Summa, Daniela Petriella, Rosanna Lacalamita, Katia Danza, Angelo Paradiso, Stefania Tommasi Tags: Research Article Source Type: research
Small Cell Undifferentiated Hepatoblastomas (SCUD): All Malignant Rhabdoid Tumors?
In conclusion, we postulate that small cell undifferentiated hepatoblastoma (HB) is not a hepatoblastoma but represents a malignant rhabdoid tumor of the liver. This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - June 30, 2016 Category: Cancer & Oncology Authors: Christian Vokuhl, Florian Oyen, Beate Häberle, Dietrich von Schweinitz, Reinhard Schneppenheim, Ivo Leuschner Tags: Research Article Source Type: research
Novel IGH and MYC Translocation Partners in Diffuse Large B Cell Lymphomas
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - June 28, 2016 Category: Cancer & Oncology Authors: Claudia Otto, René Scholtysik, Roland Schmitz, Markus Kreuz, Claudia Becher, Michael Hummel, Andreas Rosenwald, Lorenz Trümper, Wolfram Klapper, Reiner Siebert, Ralf Küppers, Tags: Research Article Source Type: research
