Mutation Patterns in Genes Encoding Interferon Signaling and Antigen Presentation: a Pan ‐Cancer Survey with Implications for the Use of Immune Checkpoint Inhibitors
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - May 3, 2017 Category: Cancer & Oncology Authors: Jan Budczies, Michael Bockmayr, Frederick Klauschen, Volker Endris, Stefan Fr öhling, Peter Schirmacher, Carsten Denkert, Albrecht Stenzinger Tags: Research Article Source Type: research
Prognostic relevance of miR ‐124‐3p and its target TP53INP1 in pediatric ependymoma
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - April 25, 2017 Category: Cancer & Oncology Authors: Yulia Margolin ‐Miller, Natalia Yanichkin, Keren Shichrur, Helen Toledano, Anat Ohali, Theophilos Tzaridis, Shalom Michowitz, Suzana Fichman‐Horn, Meora Feinmesser, Stefan M. Pfister, Hendrik Witt, Uri Tabori, Eric Bouffet, Vijay Ramaswamy, Cynthia Ha Tags: Research Article Source Type: research
A Fluorescence in Situ Hybridization ‐Based Screen Allows Rapid Detection of Adverse Cytogenetic Alterations in Patients with Acute Myeloid Leukemia
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - April 18, 2017 Category: Cancer & Oncology Authors: Nadine Sandh öfer, Klaus H. Metzeler, Purvi M. Kakadia, Zlatana Pasalic, Wolfgang Hiddemann, Michaela Neusser, Ortrud Steinlein, Michael Fiegl, Marion Subklewe, Karsten Spiekermann, Stefan K. Bohlander, Stephanie Schneider, Jan Braess Tags: Research Article Source Type: research
Table of Content Volume 56, Number 6, June 2017
(Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - April 17, 2017 Category: Cancer & Oncology Tags: Issue Information ‐ TOC Source Type: research
Differential requirements for DNA repair proteins in immortalized cell lines using alternative lengthening of telomere mechanisms
This study surveyed the requirement for requisite homologous recombination proteins, yet to be studied in human ALT cell lines, by protein depletion using RNA interference. Effects on ALT were evaluated by measuring C‐circle abundance, a marker of ALT. Surprisingly, several proteins essential for homologous recombination, BARD1, BRCA2 and WRN, were dispensable for C‐circle production, while PALB2 had varying effects on C‐circles among ALT cell lines. Depletion of homologous recombination proteins BRCA1 and BLM, which have been previously studied in ALT, decreased C‐circles in all ALT cell lines. Depletion of the no...
Source: Genes, Chromosomes and Cancer - April 11, 2017 Category: Cancer & Oncology Authors: Alaina R. Martinez, Zeenia Kaul, Jeffrey D. Parvin, Joanna Groden Tags: Research Article Source Type: research
HnRNPM and CD44s expression affects tumor aggressiveness and predicts poor prognosis in breast cancer with axillary lymph node metastases
In conclusion, overexpression of hnRNPM promotes breast cancer aggressiveness by regulating the level of CD44s, indicates a poor prognosis for patients with LNM and has potential as therapeutic targets. This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - April 10, 2017 Category: Cancer & Oncology Authors: Huizhi Sun, Tieju Liu, Dongwang Zhu, Xueyi Dong, Fang Liu, Xiaohui Liang, Chen Chen, Bing Shao, Meili Wang, Yi Wang Tags: Research Article Source Type: research
ETV6/RUNX1 ‐like acute lymphoblastic leukemia: A novel B‐cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype
In conclusion, we show that ETV6/RUNX1‐like ALL is associated with CD27p°s/CD44l°w‐neg immunophenotype and identify ARPP21 deletions to contribute to its specific genomic profile enriched for ETV6 and IKZF1 lesions. In conjunction with previously published data, our study identifies the ETV6 lesion as the only common genetic aberration and thus the most likely key driver of ETV6/RUNX1‐like ALL. This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - April 10, 2017 Category: Cancer & Oncology Authors: Marketa Zaliova, Michaela Kotrova, Silvia Bresolin, Jan Stuchly, Jan Stary, Ondrej Hrusak, Geertruy te Kronnie, Jan Trka, Jan Zuna, Martina Vaskova Tags: Research Article Source Type: research
HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - April 6, 2017 Category: Cancer & Oncology Authors: Milena Urbini, Annalisa Astolfi, Maria Abbondanza Pantaleo, Salvatore Serravalle, Angelo Paolo Dei Tos, Piero Picci, Valentina Indio, Marta Sbaraglia, Stefania Benini, Alberto Righi, Marco Gambarotti, Alessandro Gronchi, Chiara Colombo, Gian Paolo Dagrada Tags: Research Article Source Type: research
Genome ‐wide copy number variation pattern analysis and a classification signature for non‐small cell lung cancer
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - April 5, 2017 Category: Cancer & Oncology Authors: Jia ‐hao Bi, Zhe‐wei Qiu, Adi F. Gazdar, Kai Song Tags: Research Article Source Type: research
Distinct prognostic roles and heterogeneity of TTF1 copy number and TTF1 protein expression in non ‐small cell lung cancer
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - April 5, 2017 Category: Cancer & Oncology Authors: Katsuhiro Yoshimura, Yusuke Inoue, Kazutaka Mori, Yuji Iwashita, Tomoaki Kahyo, Akikazu Kawase, Masayuki Tanahashi, Hiroshi Ogawa, Naoki Inui, Kazuhito Funai, Kazuya Shinmura, Hiroshi Niwa, Takafumi Suda, Haruhiko Sugimura Tags: Research Article Source Type: research
TMEM16A/ANO1 suppression improves response to antibody ‐mediated targeted therapy of EGFR and HER2/ERBB2
Abstract
TMEM16A, a Ca2+‐activated Cl− channel, contributes to tumor growth in breast cancer and head and neck squamous cell carcinoma (HNSCC). Here, we investigated whether TMEM16A influences the response to EGFR/HER family‐targeting biological therapies. Inhibition of TMEM16A Cl− channel activity in breast cancer cells with HER2 amplification induced a loss of viability. Cells resistant to trastuzumab, a monoclonal antibody targeting HER2, showed an increase in TMEM16A expression and heightened sensitivity to Cl− channel inhibition. Treatment of HNSCC cells with cetuximab, a monoclonal antibody targeting EGFR, ...
Source: Genes, Chromosomes and Cancer - April 3, 2017 Category: Cancer & Oncology Authors: Sucheta Kulkarni, Anke Bill, Neal R. Godse, Nayel I. Khan, Jason I. Kass, Kevin Steehler, Carolyn Kemp, Kara Davis, Carol A. Bertrand, Avani R. Vyas, Douglas E. Holt, Jennifer R. Grandis, L Alex Gaither, Umamaheswar Duvvuri Tags: RESEARCH ARTICLE Source Type: research
Proteasome Ubiquitin Receptor PSMD4 is an Amplification Target in Breast Cancer and May Predict Sensitivity to PARPi
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - March 18, 2017 Category: Cancer & Oncology Authors: Marlena S. Fejzo, Lee Anderson, Hsiao ‐Wang Chen, Enrique Guandique, Ondrej Kalous, Dylan Conklin, Dennis J. Slamon Tags: Research Article Source Type: research
Table of Content Volume 56, Number 5, May 2017
(Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - March 16, 2017 Category: Cancer & Oncology Tags: Issue Information ‐ TOC Source Type: research
Variants in BAK1, SPRY4, and GAB2 are Associated with Pediatric Germ Cell Tumors: A Report from the Children's Oncology Group
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - March 13, 2017 Category: Cancer & Oncology Authors: Erin L. Marcotte, Nathan Pankratz, James F. Amatruda, A. Lindsay Frazier, Mark Krailo, Stella Davies, Jacqueline R. Starr, C. Lau Ching, Michelle Roesler, Erica Langer, Caroline Hallstrom, Anthony J. Hooten, Jenny N. Poynter Tags: Research Article Source Type: research
The Enigmatic Oncogene and Tumor Suppressor ‐like Properties of RAD54B: Insights into Genome Instability and Cancer
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - March 12, 2017 Category: Cancer & Oncology Authors: Erin N. McAndrew, Kirk J. McManus Tags: Review Article Source Type: research
