ETV6/RUNX1 ‐like acute lymphoblastic leukemia: A novel B‐cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype

In conclusion, we show that ETV6/RUNX1‐like ALL is associated with CD27p°s/CD44l°w‐neg immunophenotype and identify ARPP21 deletions to contribute to its specific genomic profile enriched for ETV6 and IKZF1 lesions. In conjunction with previously published data, our study identifies the ETV6 lesion as the only common genetic aberration and thus the most likely key driver of ETV6/RUNX1‐like ALL. This article is protected by copyright. All rights reserved.

Source: Genes, Chromosomes and Cancer - April 10, 2017 Category: Cancer & Oncology Authors: Marketa Zaliova, Michaela Kotrova, Silvia Bresolin, Jan Stuchly, Jan Stary, Ondrej Hrusak, Geertruy te Kronnie, Jan Trka, Jan Zuna, Martina Vaskova Tags: Research Article Source Type: research