An Overview of the Medical Management of Non-Melanoma Skin Cancer
Treatment of non-melanoma skin cancer (NSMC) has remained confined to a very singular approach. Surgical procedures represent more than 95% of administered treatments for basal cell carcinoma. One prospective study reported 34.2% of patients underwent Mohs, 34.5% simple excision and 26.7% destruction.1 However, some suggest tailoring treatment to patients’ needs and considering alternative modalities.2 Increasing research into medical therapeutics underscores this shift towards individualized and patient centered care. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - July 7, 2015 Category: Cancer & Oncology Authors: Lauren Metterle, Jeffrey S. Russell, Nishit S. Patel Source Type: research
Radiotherapy for management of basal and squamous cell carcinoma
More than 3.5 million cutaneous basal cell and squamous cell carcinomas are diagnosed per year in the U.S., which is more than all other cancers combined.1 The incidence of cutaneous squamous and basal cell carcinoma is also rising as a result of increased exposure to ultraviolet light or sun-light, a depleting ozone, changing clothing styles, and increasing longevity.2–4 These cancers are often excluded from cancer registries and as a result, they are under reported and their socioeconomic burden is underestimated. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - July 7, 2015 Category: Cancer & Oncology Authors: Tobin Strom, Louis B. Harrison Source Type: research
Title Page
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - July 1, 2015 Category: Cancer & Oncology Source Type: research
Table of Contents
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - July 1, 2015 Category: Cancer & Oncology Source Type: research
Penile Cancer Staging System
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 15, 2015 Category: Cancer & Oncology Source Type: research
Title Page
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 1, 2015 Category: Cancer & Oncology Source Type: research
Table of Contents
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - May 1, 2015 Category: Cancer & Oncology Source Type: research
Foreword
Brain metastases are a potentially devastating complication of malignancy, while even small volume disease burden from metastases can be functionally incapacitating. Prior to the CT era, patients typically presented with debilitating clinical manifestations of brain metastases and succumbed rapidly to disease. In today’s era, the patient population with brain metastases is far more diverse in symptoms and prognosis given early detection by advanced imaging modalities. More effective systemic therapies have led to longer survival in many diseases. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - April 18, 2015 Category: Cancer & Oncology Authors: Mark W. McDonald, Kevin P. McMullen Source Type: research
Molecular markers in penile cancer
Penile cancer is a rare disease in Europe and North America but represents a significant global health problem due to the devastating consequences of treatment and the mortality associated with metastatic disease. The most important prognostic factor is the presence of inguinal lymph node metastases. Surgical resection of inguinal lymph nodes is the only method of accurately and reliably determining lymph node status. However, in the 75-80% of cases where no metastases are found patients have undergone extensive surgery with no survival benefit. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 31, 2015 Category: Cancer & Oncology Authors: S. Rodney, A. Feber, M. Arya, A. Muneer Source Type: research
The development of a clinical trial protocol to test the timing and effectiveness of adjuvant and neoadjuvant therapy in locally advanced penile Cancer
Because of the relatively low prevalence of penis cancer, clinical trials have not been performed to determine the optimum combination of surgery, radiotherapy and chemotherapy treatment. Even early phase data is unavailable with contemporary radiation technology and chemoradiation techniques. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 31, 2015 Category: Cancer & Oncology Authors: Jim Barber Source Type: research
Epidemiology of Penile Cancer
Penile cancer is a rare genital malignancy with the majority of lesions histologically classified as squamous cell carcinomas. Although it is a rare tumour in developed countries, the incidence of penile cancer is significantly higher in developing countries.1 In this section we review the epidemiology of penile cancer in different population groups globally and also examine predisposing risk factors. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 31, 2015 Category: Cancer & Oncology Authors: Michelle Christodoulidou, Varun Sahdev, Selda Houssein, Asif Muneer Source Type: research
Introduction
Current Problems in Cancer is devoting this entire issue to the subject of Penile Cancer, a relatively rare malignancy in the western world, highly curable when detected early but often ignored and hidden from medical view until too late and thus presenting with an advanced stage at which time the diagnosis is devastating, treatment is mutilating and the disease is often fatal. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 30, 2015 Category: Cancer & Oncology Authors: Juanita Crook Source Type: research
Current Surgical Management of Penile Cancer
Surgical resection of the primary penile tumor should result in complete removal of the cancerous lesion with as much organ preservation as possible to preserve functional and cosmetic outcomes and avoid psychological distress. This is especially important in patients who develop penile cancer at a younger age (approximately 20% (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 30, 2015 Category: Cancer & Oncology Authors: Pranav Sharma, Kamran Zargar-Shoshtari, Philippe E. Spiess Source Type: research
The role of radiotherapy in the management of penile Cancer
Just as for Squamous Carcinoma (SCC) in other body sites such as head and neck, cervix, and vulva, radiotherapy plays an important role in the management of SCC of the penis. In localized presentations, curative treatment with the important secondary endpoint of organ preservation can be offered. For localized tumours with a high risk of nodal involvement, management of the primary with radiation can be combined with surgical staging of the lymph nodes. In locoregionally advanced cases, combined radiation and chemotherapy can be used either as definitive treatment or in a pre-operative scenario to be followed by surgery wh...
Source: Current Problems in Cancer - March 30, 2015 Category: Cancer & Oncology Authors: Juanita Crook Source Type: research
Role of Chemotherapy in Treatment of Squamous Cell Carcinoma of the Penis
As with most epithelial malignancies, the treatment of squamous cell carcinoma of the penis (SCCP) in the most advanced stage of disease has historically included chemotherapy. Foundational evidence for the role of chemotherapy emerged from a multicenter phase II study, conducted by the Southwest Oncology Group (SWOG) of cisplatin monotherapy for patients with metastatic SCCP.1 Building on these results, there have been several two-drug and three-drug regimens studied prospectively (Table), but no randomized trial; and without a randomized trial, no single drug combination has yet been designated as the standard, or even a...
Source: Current Problems in Cancer - March 30, 2015 Category: Cancer & Oncology Authors: Lance C. Pagliaro Source Type: research
