Role of Chemotherapy in Treatment of Squamous Cell Carcinoma of the Penis

As with most epithelial malignancies, the treatment of squamous cell carcinoma of the penis (SCCP) in the most advanced stage of disease has historically included chemotherapy. Foundational evidence for the role of chemotherapy emerged from a multicenter phase II study, conducted by the Southwest Oncology Group (SWOG) of cisplatin monotherapy for patients with metastatic SCCP.1 Building on these results, there have been several two-drug and three-drug regimens studied prospectively (Table), but no randomized trial; and without a randomized trial, no single drug combination has yet been designated as the standard, or even as having statistically significant superiority over single-agent cisplatin.
Source: Current Problems in Cancer - Category: Cancer & Oncology Authors: Source Type: research