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(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 1, 2017 Category: Cancer & Oncology Source Type: research
Human papillomavirus and oral squamous cell carcinoma: A review of HPV-positive oral squamous cell carcinoma and possible strategies for future
Oral squamous cell carcinoma (OSCC) is a common cancer worldwide. Besides tobacco use and alcohol consumption, human papillomavirus (HPV) infection has also been identified as a risk factor for OSCC recently. The OSCC incidence has increased in recent years, especially among younger women. The purpose of this article is to review clinical and epidemiological studies on the association between HPV infection and OSCCs, and the efficacy of HPV vaccine, so as to provide possible policy implications for preventing HPV-positive OSCC. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - March 1, 2017 Category: Cancer & Oncology Authors: Shan Jiang, Yong Dong Source Type: research
Circulating tumor DNA —From bench to bedside
In the era of personalized medicine, tumor sampling is paramount to enable the assessment of actionable molecular aberrations to help rationalize and guide treatment decisions. Longitudinal tracking of such aberrations may also be helpful to detect emerging drug resistance and to allow for timely modifications to ongoing therapies to improve patient outcomes. Nevertheless, tumor tissue sampling involves an invasive procedure with potential risks to patients and involves logistical challenges. As such, other less invasive and safer methods such as blood sampling for molecular profiling has been gaining traction. (Source: Cu...
Source: Current Problems in Cancer - March 1, 2017 Category: Cancer & Oncology Authors: Joline S.J. Lim, Filip Janku, Timothy A. Yap Source Type: research
HPV and Oral Squamous Cell Carcinoma: A Review of HPV-positive OSCC and Possible Strategies for Future
Oral Squamous Cell Carcinoma (OSCC) is a common cancer worldwide. Besides tobacco use and alcohol consumption, Human Papillomavirus (HPV) infection has also been identified as a risk factor for OSCC recently. The OSCC incidence has increased in recent years, especially among younger women. The purpose of this paper is to review clinical and epidemiological studies on the association between HPV infection and OSCCs, and the efficacy of HPV vaccine, so as to provide possible policy implications for preventing HPV-positive OSCC. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 28, 2017 Category: Cancer & Oncology Authors: Shan Jiang, Yong Dong Source Type: research
Circulating tumor DNA – from bench to bedside
In the era of personalized medicine, tumor sampling is paramount to enable the assessment of actionable molecular aberrations to help rationalize and guide treatment decisions. Longitudinal tracking of such aberrations may also be helpful to detect emerging drug resistance and to allow for timely modifications to ongoing therapies to improve patient outcomes. Nevertheless, tumor tissue sampling involves an invasive procedure with potential risks to patients and involves logistical challenges. As such, other less invasive and safer methods such as blood sampling for molecular profiling has been gaining traction. (Source: Cu...
Source: Current Problems in Cancer - February 28, 2017 Category: Cancer & Oncology Authors: Joline Lim, Filip Janku, Timothy A. Yap Source Type: research
The Current Status and Problems Confronted in Delivering Precision Medicine in Japan and Europe
Precision medicine has been defined as “a predictive, preventive, personalized, and participatory healthcare service delivery model.” Today, developments in next-generation sequencing and information technology have made precision medicine possible, with massive amounts of genetic, “omics,” clinical, environmental, and lifestyle data now available. Unfortunately, differences in governmental support and healthcare regulations have resulted in heterogeneous progress among countries. In Japan, for example, precision cancer screening and treatments are increasingly being promoted, with collaboration among research, gov...
Source: Current Problems in Cancer - February 20, 2017 Category: Cancer & Oncology Authors: Hideaki Bando Source Type: research
Initiative for Molecular Profiling and Advanced Cancer Therapy and challenges in the implementation of precision medicine
In the last decade, breakthroughs in technology have improved our understanding of genomic, transcriptional, proteomic, epigenetic aberrations and immune mechanisms in carcinogenesis. Genomics and model systems have enabled the validation of novel therapeutic strategies. Based on these developments, in 2007, we initiated the IMPACT (Initiative for Molecular Profiling and Advanced Cancer Therapy) study, the first personalized medicine program for patients with advanced cancer at The University of Texas MD Anderson Cancer Center. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 10, 2017 Category: Cancer & Oncology Authors: Apostolia-Maria Tsimberidou Source Type: research
Defining precision: The precision medicine initiative TRIALS NCI-MPACT and NCI-MATCH
‘Precision′ trials, using rationally incorporated biomarker targets and molecularly selective anti-cancer agents, have become of great interest to both patients and their physicians. In the endeavor to test the cornerstone premise of precision oncotherapy, that is, determining if modulating a sp ecific molecular aberration in a patient′s tumor with a correspondingly specific therapeutic agent improves clinical outcomes, the design of clinical trials with embedded genomic characterization platforms which guide therapy are an increasing challenge. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 9, 2017 Category: Cancer & Oncology Authors: Geraldine O ’Sullivan Coyne, Naoko Takebe, Alice P. Chen Source Type: research
Initiative for Molecular Profiling and Advanced Cancer Therapy and Challenges in Implementation of Precision Medicine
Precision medicine is a form of medicine that uses information about a person ′s genes, proteins, and environment to prevent, diagnose, and treat disease. Initially, the term “precision medicine” was used to describe targeting tumor molecular abnormalities with drugs known to inhibit the function of a molecular alteration. In recent years, precision medicine has include d the development of therapeutic agents that target any biological abnormality that is associated with the development of cancer. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 9, 2017 Category: Cancer & Oncology Authors: Apostolia-Maria Tsimberidou Source Type: research
Pediatric oncology enters an era of precision medicine
This article reviews the early studies in pediatric oncology showing the feasibility of this approach, describe the future plans to evaluate the clinical implications in a multicenter clinical trial and identify the challenges of applying genomics in this patient population. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - February 1, 2017 Category: Cancer & Oncology Authors: Nita L. Seibel, Katherine Janeway, Carl E. Allen, Susan N. Chi, Yoon-Jae Cho, Julia L. Glade Bender, AeRang Kim, Theodore W. Laetsch, Meredith S. Irwin, Naoko Takebe, James V. Tricoli, Donald Williams Parsons Source Type: research
Pediatric Oncology Enters the Era of Precision Medicine
This article will review the early studies in pediatric oncology showing the feasibility of this approach, describe the future plans to evaluate the clinical implications in a multicenter clinical trial and identify the challenges of applying genomics in this patient population. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 31, 2017 Category: Cancer & Oncology Authors: Nita L. Seibel, Katherine Janeway, Carl E. Allen, Susan N. Chi, Y Jae Cho, Julia L. Glade Bender, AeRang Kim, Theodore W. Laetsch, Meredith S. Irwin, Naoko Takebe, James V. Tricoli, D. Williams Parsons Source Type: research
Precision Medicine in Oncology
Advancements in cancer genomics have led to a new era of precision medicine in oncology. It is now commonplace for a patient ′s tumor to be extensively profiled for molecular abnormalities, and anticancer treatments to be based mainly on the identified underlying alterations, rather than just cancer histology. This capability is a critical advance in cancer medicine since molecularly targeted agents may ultimately only benefit patients when their tumors are molecularly characterized and rationally matched with an antitumor agent with known mechanisms of action. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 23, 2017 Category: Cancer & Oncology Authors: Naoko Takebe, Timothy A. Yap Tags: SI: Precision Medicine in Oncology Source Type: research
Women ’s cancer: Advancing molecular and immunotherapy
In recent years, our understanding of important biological mechanisms that control the growth of women ’s cancer has increased significantly. The development of novel high throughput laboratory technologies has allowed the generation of unprecedented large data sets that are being analyzed by sophisticated bioinformatics algorithms. The Cancer Genome Atlas project has provided comprehensive genomic data for breast, ovarian, endometrial, and cervical cancers, which is accessible to scientists worldwide. (Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 1, 2017 Category: Cancer & Oncology Authors: Oliver Dorigo Source Type: research
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(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 1, 2017 Category: Cancer & Oncology Source Type: research
Table of Contents
(Source: Current Problems in Cancer)
Source: Current Problems in Cancer - January 1, 2017 Category: Cancer & Oncology Source Type: research
